7MIJ
| Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (1.98 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIK
| Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIN
| Mouse TRPV3 in cNW11 nanodiscs, closed state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIM
| Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIL
| Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7LYC
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777) | 分子名称: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | 登録日 | 2021-03-06 | 公開日 | 2021-06-16 | 最終更新日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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7E8I
| Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin | 分子名称: | BRCA1-associated RING domain protein 1, DNA (145-MER), Histone H2A, ... | 著者 | Dai, Y, Dai, L, Zhou, Z. | 登録日 | 2021-03-01 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin. Mol.Cell, 81, 2021
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7LQY
| Structure of squirrel TRPV1 in apo state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol, CHLORIDE ION, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-02-15 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
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7LR0
| Structure of squirrel TRPV1 in complex with capsaicin | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-02-15 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
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7LQZ
| Structure of squirrel TRPV1 in complex with RTX | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-02-15 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
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7E4T
| Human TRPC5 apo state structure at 3 angstrom | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2021-02-15 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7LPA
| Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPE
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPB
| Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPD
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LP9
| Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPC
| Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7L2W
| cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state a | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2R
| Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2N
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7L2L
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7L2S
| cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2O
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7L2J
| Cryo-EM structure of full-length TRPV1 at pH6c state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, Transient receptor potential cation channel subfamily V member 1 | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2T
| cryo-EM structure of DkTx-bound minimal TRPV1 in partial open state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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