7L2S

cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state

Summary for 7L2S

Entry DOI	10.2210/pdb7l2s/pdb
EMDB information	23139
Descriptor	Transient receptor potential cation channel subfamily V member 1, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, ... (4 entities in total)
Functional Keywords	trp channel, cryo-em, nanodisc, toxin, transport protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	296753.81
Authors	Zhang, K.,Julius, D.,Cheng, Y. (deposition date: 2020-12-17, release date: 2021-09-22, Last modification date: 2021-10-13)
Primary citation	Zhang, K.,Julius, D.,Cheng, Y. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184:5138-5150.e12, 2021 Cited by PubMed: 34496225 DOI: 10.1016/j.cell.2021.08.012 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.71 Å)

Structure validation