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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7L2S

cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	ILE433-TYR453
A	ILE433-TYR453
B	ILE433-TYR453
C	ILE433-TYR453

site_id	SWS_FT_FI2
Number of Residues	212
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	TYR454-ASP471
B	SER532-LYS535
B	GLU600-PHE649
B	LEU673-ALA680
C	TYR454-ASP471
C	SER532-LYS535
C	GLU600-PHE649
C	LEU673-ALA680
D	SER532-LYS535
D	GLU600-PHE649
D	LEU673-ALA680
A	TYR454-ASP471
A	SER532-LYS535
A	GLU600-PHE649
A	LEU673-ALA680
B	TYR454-ASP471

site_id	SWS_FT_FI3
Number of Residues	100
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	TYR472-LEU497
A	TYR472-LEU497
B	TYR472-LEU497
C	TYR472-LEU497

site_id	SWS_FT_FI4
Number of Residues	104
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	GLN498-SER510
D	ARG557-LYS571
A	GLN498-SER510
A	ARG557-LYS571
B	GLN498-SER510
B	ARG557-LYS571
C	GLN498-SER510
C	ARG557-LYS571

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	TYR511-PHE531
A	TYR511-PHE531
B	TYR511-PHE531
C	TYR511-PHE531

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	GLU536-THR556
A	GLU536-THR556
B	GLU536-THR556
C	GLU536-THR556

site_id	SWS_FT_FI7
Number of Residues	108
Details	TRANSMEM: Helical; Name=S5 => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	MET572-ILE599
A	MET572-ILE599
B	MET572-ILE599
C	MET572-ILE599

site_id	SWS_FT_FI8
Number of Residues	88
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	THR650-ILE672
A	THR650-ILE672
B	THR650-ILE672
C	THR650-ILE672

site_id	SWS_FT_FI9
Number of Residues	112
Details	TRANSMEM: Helical; Name=S6 => ECO:0000269\|PubMed:24305160, ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:3J5P, ECO:0007744\|PDB:5IRX, ECO:0007744\|PDB:5IRZ, ECO:0007744\|PDB:5IS0

Chain	Residue	Details
D	LEU681-GLU709
A	LEU681-GLU709
B	LEU681-GLU709
C	LEU681-GLU709

site_id	SWS_FT_FI10
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2PNN

Chain	Residue	Details
D	ARG115
C	ARG115
C	LYS155
C	GLU210
D	LYS155
D	GLU210
A	ARG115
A	LYS155
A	GLU210
B	ARG115
B	LYS155
B	GLU210

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2NYJ, ECO:0007744\|PDB:2PNN

Chain	Residue	Details
D	LYS160
C	LYS160
C	ASN164
C	TYR199
D	ASN164
D	TYR199
A	LYS160
A	ASN164
A	TYR199
B	LYS160
B	ASN164
B	TYR199

site_id	SWS_FT_FI12
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:27281200, ECO:0007744\|PDB:5IRX

Chain	Residue	Details
D	TYR511
C	TYR511
C	THR550
C	ARG557
D	THR550
D	ARG557
A	TYR511
A	THR550
A	ARG557
B	TYR511
B	THR550
B	ARG557

site_id	SWS_FT_FI13
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q8NER1

Chain	Residue	Details
D	TYR666
A	TYR666
B	TYR666
C	TYR666

site_id	SWS_FT_FI14
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9R186

Chain	Residue	Details
D	LEU669
A	LEU669
B	LEU669
C	LEU669

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269\|PubMed:12194871, ECO:0000269\|PubMed:15471852

Chain	Residue	Details
D	SER116
A	SER116
B	SER116
C	SER116

site_id	SWS_FT_FI16
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269\|PubMed:12194871

Chain	Residue	Details
D	THR144
D	THR370
A	THR144
A	THR370
B	THR144
B	THR370
C	THR144
C	THR370

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269\|PubMed:11884385, ECO:0000269\|PubMed:12194871, ECO:0000269\|PubMed:14630912

Chain	Residue	Details
D	SER502
A	SER502
B	SER502
C	SER502

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:14630912

Chain	Residue	Details
D	GLN727
A	GLN727
B	GLN727
C	GLN727

site_id	SWS_FT_FI19
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:11683872

Chain	Residue	Details
D	TYR627
A	TYR627
B	TYR627
C	TYR627

237735

PDB entries from 2025-06-18

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