PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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2IUG	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
8S0J	A fragment-based inhibitor of SHP2 分子名称: 3-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]propan-1-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-14 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
1O4P	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791. 分子名称: 2-PHENYLMALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
2HUW	X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand 分子名称: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION 著者 Benfield, A.P, Martin, S.F. 登録日 2006-07-27 公開日 2006-08-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 45, 2006
4FL3	Structural and Biophysical Characterization of the Syk Activation Switch 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK 著者 Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. 登録日 2012-06-14 公開日 2012-11-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
1IS0	Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor 分子名称: AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC 著者 Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. 登録日 2001-11-02 公開日 2002-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124, 2002
1NZL	Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI 分子名称: CHLORIDE ION, Doubly phosphorylated peptide ligand (PQpYEpYIPI), TETRAETHYLENE GLYCOL, ... 著者 Lubman, O.Y, Waksman, G. 登録日 2003-02-18 公開日 2003-04-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor J.Mol.Biol., 328, 2003
7Q63	The tandem SH2 domains of SYK 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. 登録日 2021-11-05 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The tandem SH2 domains of SYK To Be Published
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide 分子名称: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 著者 Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. 登録日 2010-03-24 公開日 2010-05-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
1BHH	FREE P56LCK SH2 DOMAIN 分子名称: P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK 著者 Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. 登録日 1998-06-08 公開日 1998-10-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. J.Biol.Chem., 273, 1998
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide 分子名称: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 著者 Morris, R, Kershaw, N.J, Babon, J.J. 登録日 2021-06-27 公開日 2021-10-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
2C9W	CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION 分子名称: NICKEL (II) ION, SULFATE ION, SUPPRESSOR OF CYTOKINE SIGNALING 2, ... 著者 Debreczeni, J.E, Bullock, A, Amos, A, Savitsky, P, Barr, A, Burgess, N, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S. 登録日 2005-12-14 公開日 2006-02-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
2OQ1	Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide 分子名称: LEAD (II) ION, T-cell surface glycoprotein CD3 zeta chain, Tyrosine-protein kinase ZAP-70 著者 Hatada, M.H, Laird, E.R, Green, J, Morgenstern, J, Ram, M.K. 登録日 2007-01-30 公開日 2007-03-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for the interaction of ZAP-70 with the T-cell receptor Nature, 377, 1995
2H46	Native domain-swapped dimer crystal structure of the Grb2 SH2 domain 分子名称: GLYCEROL, Growth Receptor Binding Protein 2 著者 Benfield, A.P, Martin, S.F, Whiddon, B.B. 登録日 2006-05-23 公開日 2006-06-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
1R1S	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads 分子名称: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION 著者 Cho, S, Mariuzza, R.A. 登録日 2003-09-24 公開日 2004-09-28 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
8RZY	A fragment-based inhibitor of SHP2 分子名称: 1H-pyrrolo[3,2-b]pyridin-5-amine, DIMETHYL SULFOXIDE, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-13 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
1Y57	Structure of unphosphorylated c-Src in complex with an inhibitor 分子名称: 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION 著者 Cowan-Jacob, S.W, Fendrich, G, Manley, P.W, Jahnke, W, Fabbro, D, Liebetanz, J, Meyer, T. 登録日 2004-12-02 公開日 2005-06-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation Structure, 13, 2005
7JVN	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24 分子名称: 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Fodor, M, Stams, T. 登録日 2020-08-21 公開日 2020-09-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.917 Å) 主引用文献 Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer. J.Med.Chem., 63, 2020
7ZLS	co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 分子名称: 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
8S0I	A fragment-based inhibitor of SHP2 分子名称: 3-phenyl-1H-pyrrolo[3,2-b]pyridine, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-14 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
7ZLP	Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9 分子名称: Elongin-B, Elongin-C, PHOSPHATE ION, ... 著者 Ramachandran, S, Ciulli, A, Makukhin, N. 登録日 2022-04-15 公開日 2023-04-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
8S0S	A fragment-based inhibitor of SHP2 分子名称: (1R,5S)-8-[7-(4-chloranyl-2-methyl-indazol-5-yl)-5H-pyrrolo[2,3-b]pyrazin-3-yl]-8-azabicyclo[3.2.1]octan-3-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-14 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
5H09	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-ethyl2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoate 分子名称: Tyrosine-protein kinase HCK, ethyl (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate 著者 Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. 登録日 2016-10-04 公開日 2017-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.945 Å) 主引用文献 Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
5MTJ	Yes1-SH2 in complex with monobody Mb(Yes_1) 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ... 著者 Sha, F, Kukenshoner, T, Koide, S, Hantschel, O. 登録日 2017-01-09 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
8XN8	The Crystal Structure of SRC from Biortus. 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. 登録日 2023-12-29 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Crystal Structure of SRC from Biortus. To Be Published

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