7FBA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fba by Molmil](/molmil-images/mine/7fba) | De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd2 | 分子名称: | ALA-LE1-CYS-GLU-CYS-GLY-PRO-THR-ARG-GLU-CYS-LYS-NH2, GLU-CYS-ARG-GLU-TYR-GLY-PRO-LE1-LYS-LE1-LE1-ALA-NH2 | 著者 | Yao, H, Yao, S, Moyer, A, Zheng, Y, Baker, D, Wu, C. | 登録日 | 2021-07-08 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design and directed folding of disulfide-bridged peptide heterodimers. Nat Commun, 13, 2022
|
|
8UP1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8up1 by Molmil](/molmil-images/mine/8up1) | |
8UTM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8utm by Molmil](/molmil-images/mine/8utm) | |
6NAF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6naf by Molmil](/molmil-images/mine/6naf) | De novo designed homo-trimeric amantadine-binding protein | 分子名称: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, SODIUM ION, amantadine-binding protein | 著者 | Selvaraj, B, Park, J, Cuneo, M.J, Myles, D.A.A, Baker, D. | 登録日 | 2018-12-05 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-25 | 実験手法 | NEUTRON DIFFRACTION (1.923 Å), X-RAY DIFFRACTION | 主引用文献 | De novo design of a homo-trimeric amantadine-binding protein. Elife, 8, 2019
|
|
6N9H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6n9h by Molmil](/molmil-images/mine/6n9h) | De novo designed homo-trimeric amantadine-binding protein | 分子名称: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, SODIUM ION, amantadine-binding protein | 著者 | Park, J, Baker, D. | 登録日 | 2018-12-03 | 公開日 | 2019-12-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.039 Å) | 主引用文献 | De novo design of a homo-trimeric amantadine-binding protein. Elife, 8, 2019
|
|
6DG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dg5 by Molmil](/molmil-images/mine/6dg5) | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.516 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
|
|
8GLT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8glt by Molmil](/molmil-images/mine/8glt) | Backbone model of de novo-designed chlorophyll-binding nanocage O32-15 | 分子名称: | C2-chlorophyll-comp_O32-15_ctermHis, polyalanine model, C3-comp_O32-15 | 著者 | Redler, R.L, Ennist, N.M, Wang, S, Baker, D, Ekiert, D.C, Bhabha, G. | 登録日 | 2023-03-23 | 公開日 | 2024-03-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | De novo design of proteins housing excitonically coupled chlorophyll special pairs. Nat.Chem.Biol., 20, 2024
|
|
6DG6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dg6 by Molmil](/molmil-images/mine/6dg6) | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | 分子名称: | Neoleukin-2/15 | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
|
|
6WXO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wxo by Molmil](/molmil-images/mine/6wxo) | De novo TIM barrel-ferredoxin fold fusion homodimer with 2-histidine 2-glutamate centre TFD-HE | 分子名称: | GLYCEROL, SULFATE ION, TFD-HE | 著者 | Caldwell, S.J, Zeymer, C, Haydon, I.C, Huang, P, Hilvert, D, Baker, D. | 登録日 | 2020-05-11 | 公開日 | 2020-11-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7UDJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7udj by Molmil](/molmil-images/mine/7udj) | Crystal structure of designed helical repeat protein RPB_PEW3_R4 bound to PAWx4 peptide | 分子名称: | 4xPAW peptide, De novo designed helical repeat protein RPB_PEW3_R4 | 著者 | Redler, R.L, Chang, Y, Bhabha, G, Ekiert, D. | 登録日 | 2022-03-20 | 公開日 | 2023-03-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
|
|
7UR7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ur7 by Molmil](/molmil-images/mine/7ur7) | |
7UR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ur8 by Molmil](/molmil-images/mine/7ur8) | |
7DKO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dko by Molmil](/molmil-images/mine/7dko) | De novo design protein AM2M | 分子名称: | de novo designed protein AM2M | 著者 | Bin, H. | 登録日 | 2020-11-25 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
7DGU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dgu by Molmil](/molmil-images/mine/7dgu) | |
7DKK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dkk by Molmil](/molmil-images/mine/7dkk) | De novo design protein XM2H | 分子名称: | De novo design protein XM2H | 著者 | Bin, H. | 登録日 | 2020-11-24 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
|
|
7DGY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dgy by Molmil](/molmil-images/mine/7dgy) | |
7XAD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xad by Molmil](/molmil-images/mine/7xad) | Crystal strucutre of PD-L1 and DBL2_02 designed protein binder | 分子名称: | DBL2_02 binder, Programmed cell death 1 ligand 1 | 著者 | Liu, K.F, Xu, Z.P, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.G. | 登録日 | 2022-03-17 | 公開日 | 2023-04-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
|
|
6EIK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eik by Molmil](/molmil-images/mine/6eik) | A de novo designed heptameric coiled coil CC-Hept-I24E | 分子名称: | CC-Hept-I24E, FORMIC ACID, GLYCEROL | 著者 | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | 登録日 | 2017-09-19 | 公開日 | 2018-07-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules. ACS Synth Biol, 7, 2018
|
|
6EIZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eiz by Molmil](/molmil-images/mine/6eiz) | A de novo designed hexameric coiled coil CC-Hex2 with farnesol bound in the channel. | 分子名称: | (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, CC-Hex2 | 著者 | Rhys, G.G, Burton, A.J, Dawson, W.M, Thomas, F, Woolfson, D.N. | 登録日 | 2017-09-19 | 公開日 | 2018-07-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | De Novo-Designed alpha-Helical Barrels as Receptors for Small Molecules. ACS Synth Biol, 7, 2018
|
|
7Q1R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q1r by Molmil](/molmil-images/mine/7q1r) | A de novo designed homo-dimeric antiparallel coiled coil apCC-Di | 分子名称: | ETHANOL, SODIUM ION, apCC-Di | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | 登録日 | 2021-10-20 | 公開日 | 2022-07-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation. Nat.Chem.Biol., 18, 2022
|
|
7Q1S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q1s by Molmil](/molmil-images/mine/7q1s) | A de novo designed hetero-dimeric antiparallel coiled coil apCC-Di-AB_var | 分子名称: | 1,2-ETHANEDIOL, apCC-Di-A_var, apCC-Di-B_var | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | 登録日 | 2021-10-20 | 公開日 | 2022-07-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation. Nat.Chem.Biol., 18, 2022
|
|
7Q1T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q1t by Molmil](/molmil-images/mine/7q1t) | A de novo designed hetero-dimeric antiparallel coiled coil apCC-Di-AB | 分子名称: | N-PROPANOL, SULFATE ION, apCC-Di-A, ... | 著者 | Shanmugaratnam, S, Rhys, G.G, Dawson, W.M, Woolfson, D.N, Hocker, B. | 登録日 | 2021-10-20 | 公開日 | 2022-07-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | De novo designed peptides for cellular delivery and subcellular localisation. Nat.Chem.Biol., 18, 2022
|
|
6WXP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wxp by Molmil](/molmil-images/mine/6wxp) | De novo TIM barrel-ferredoxin fold fusion homodimer with 4-glutamate centre TFD-EE | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, TFD-EE | 著者 | Caldwell, S.J, Zeymer, C, Haydon, I.C, Huang, P, Hilvert, D, Baker, D. | 登録日 | 2020-05-11 | 公開日 | 2020-11-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5C2M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c2m by Molmil](/molmil-images/mine/5c2m) | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | Predicted protein | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
|
|
5C2N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c2n by Molmil](/molmil-images/mine/5c2n) | The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta propeller | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-01-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
|
|