8D80
 
 | | Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3 | | 分子名称: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, DNA-binding protein Ikaros, ... | | 著者 | Watson, E.R, Lander, G.C. | | 登録日 | 2022-06-07 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
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8J90
 | | Cryo-EM structure of DDM1-nucleosome complex | | 分子名称: | ATP-dependent DNA helicase DDM1, DNA (169-MER), HTA6, ... | | 著者 | Osakabe, A, Takizawa, Y, Horikoshi, N, Hatazawa, S, Berger, F, Kurumizaka, H, Kakutani, T. | | 登録日 | 2023-05-02 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (4.71 Å) | | 主引用文献 | Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1.
Nat Commun, 15, 2024
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6W5C
 | | Cryo-EM structure of Cas12i(E894A)-crRNA-dsDNA complex | | 分子名称: | Cas12i, NTS, Substrate, ... | | 著者 | Chang, L, Li, Z, Zhang, H. | | 登録日 | 2020-03-13 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease.
Nat.Struct.Mol.Biol., 27, 2020
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1RDR
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2O6M
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8KCB
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8KCC
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7MHT
 | | CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX | | 分子名称: | 5'-D(P*CP*CP*AP*TP*GP*AP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... | | 著者 | O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. | | 登録日 | 1998-08-05 | | 公開日 | 1998-11-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | | 主引用文献 | Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
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1CYQ
 | | INTRON ENCODED HOMING ENDONUCLEASE I-PPOI (H98A)/DNA HOMING SITE COMPLEX | | 分子名称: | 5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3', INTRON-ENCODED HOMING ENDONUCLEASE I-PPOI, MAGNESIUM ION, ... | | 著者 | Galburt, E.A, Chevalier, B, Jurica, M.S, Flick, K.E, Stoddard, B.L. | | 登録日 | 1999-08-31 | | 公開日 | 1999-11-19 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | A novel endonuclease mechanism directly visualized for I-PpoI.
Nat.Struct.Biol., 6, 1999
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2B0K
 | | Crystal structure of the DB921-D(CGCGAATTCGCG)2 complex. | | 分子名称: | 2-(4'-AMIDINOBIPHENYL-4-YL)-1H-BENZIMIDAZOLE-5-AMIDINE, 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION | | 著者 | Miao, Y, Lee, M.P, Parkinson, G.N, Batista-Parra, A, Ismail, M.A, Neidle, S, Boykin, D.W, Wilson, W.D. | | 登録日 | 2005-09-14 | | 公開日 | 2005-11-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Out-of-Shape DNA Minor Groove Binders: Induced Fit Interactions of Heterocyclic Dications with the DNA Minor Groove.
Biochemistry, 44, 2005
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2DA8
 | | SOLUTION STRUCTURE OF A COMPLEX BETWEEN (N-MECYS3,N-MECYS7)TANDEM AND (D(GATATC))2 | | 分子名称: | 2-CARBOXYQUINOXALINE, CysMeTANDEM quinoxaline antibiotic, DNA (5'-D(*GP*AP*TP*AP*TP*C)-3') | | 著者 | Addess, K.J, Sinsheimer, J.S, Feigon, J. | | 登録日 | 1993-04-09 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-08-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of a Complex between [N-Mecys3,N-Mecys7]Tandem and [D(Gatatc)]2.
Biochemistry, 32, 1993
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4G0R
 | | Structural characterization of H-1 Parvovirus: comparison of infectious virions to replication defective particles | | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... | | 著者 | Halder, S, Agbandje-McKenna, M, Nam, H.-J, Govindasamy, L, Vogel, M, Dinsart, C, Salome, N, McKenna, R. | | 登録日 | 2012-07-09 | | 公開日 | 2013-02-27 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural characterization of h-1 parvovirus: comparison of infectious virions to empty capsids.
J.Virol., 87, 2013
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7EL1
 | | Structure of a protein from bacteria | | 分子名称: | 100AA, CRISPR-associated endonuclease Cas9, DNA (28-MER), ... | | 著者 | Liu, H, Zhu, Y, Huang, Z. | | 登録日 | 2021-04-07 | | 公開日 | 2021-07-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14.
Nucleic Acids Res., 49, 2021
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1EO4
 | | ECORV BOUND TO MN2+ AND COGNATE DNA CONTAINING A 3'S SUBSTITION AT THE CLEAVAGE SITE | | 分子名称: | ACETIC ACID, DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), MANGANESE (II) ION, ... | | 著者 | Horton, N.C, Connolly, B.A, Perona, J.J. | | 登録日 | 2000-03-21 | | 公開日 | 2000-04-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
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8IGI
 | | Crystal structure of HP1526 (XthA)- a base excision DNA repair protein in Helicobacter pylori | | 分子名称: | 1,3-BUTANEDIOL, Exodeoxyribonuclease (LexA), MANGANESE (II) ION | | 著者 | Dinh, T.T, Dao, O, Lee, K.H. | | 登録日 | 2023-02-20 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Crystal structure of the apurinic/apyrimidinic endonuclease XthA (HP1526 protein) from Helicobacter pylori.
Biochem.Biophys.Res.Commun., 663, 2023
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1B94
 | | RESTRICTION ENDONUCLEASE ECORV WITH CALCIUM | | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3'), RESTRICTION ENDONUCLEASE ECORV | | 著者 | Thomas, M.P, Halford, S.E, Brady, R.L. | | 登録日 | 1999-02-19 | | 公開日 | 1999-02-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group.
Nucleic Acids Res., 27, 1999
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4I2D
 | | Binary complex of mouse TdT with AMPcPP | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA nucleotidylexotransferase, MAGNESIUM ION, ... | | 著者 | Gouge, J, Delarue, M. | | 登録日 | 2012-11-21 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism.
J.Mol.Biol., 425, 2013
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1FD5
 | | BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (BISACRIDINE COMPLEX) | | 分子名称: | COBALT (II) ION, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), MACROCYCLIC-BIS-9-AMINO-ACRIDINE, ... | | 著者 | Yang, X.-L, Robinson, H, Gao, Y.-G, Wang, A.H.-J. | | 登録日 | 2000-07-19 | | 公開日 | 2000-08-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
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8MHT
 | | CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX | | 分子名称: | 5'-D(P*CP*CP*AP*TP*GP*UP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... | | 著者 | O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. | | 登録日 | 1998-08-06 | | 公開日 | 1998-11-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
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1FDG
 | | BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX) | | 分子名称: | 1,4-BIS-[2-(2-HYDROXY-ETHYLAMINO)-ETHYLAMINO]-ANTHRAQUINONE, COBALT (II) ION, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), ... | | 著者 | Yang, X.-L, Robinson, H, Gao, Y.-G, Wang, A.H.-J. | | 登録日 | 2000-07-20 | | 公開日 | 2000-08-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
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7BIL
 | | Crystal structure of helicase Pif1 from Thermus oshimai in complex with oligo GGTTTGGTTTGGTT | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*GP*GP*TP*TP*TP*GP*GP*TP*TP*TP*GP*GP*TP*T)-3'), MAGNESIUM ION, ... | | 著者 | Dai, Y.X, Chen, W.F, Teng, F.Y, Liu, N.N, Hou, X.M, Dou, S.X, Rety, S, Xi, X.G. | | 登録日 | 2021-01-12 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.
Nucleic Acids Res., 49, 2021
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6BYY
 | | MEF2 CHIMERA/DNA Complex | | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ... | | 著者 | Lei, X, Chen, L. | | 登録日 | 2017-12-21 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
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2K71
 | | Structure and dynamics of a DNA GNRA hairpin solved vy high-sensitivity NMR with two independent converging methods, simulated annealing (DYANA) and mesoscopic molecular modelling (BCE/AMBER) | | 分子名称: | 5'-D(*DGP*DCP*DGP*DAP*DAP*DAP*DGP*DC)-3' | | 著者 | Santini, G.P.H, Cognet, J.A.H, Xu, D, Singarapu, K.K, Herve du Penhoat, C.L.M. | | 登録日 | 2008-07-29 | | 公開日 | 2009-07-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Nucleic acid folding determined by mesoscale modeling and NMR spectroscopy: solution structure of d(GCGAAAGC).
J.Phys.Chem.B, 113, 2009
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2KF7
 | | Structure of a two-G-tetrad basket-type intramolecular G-quadruplex formed by human telomeric repeats in K+ solution (with G7-to-BRG substitution) | | 分子名称: | HUMAN TELOMERE DNA | | 著者 | Lim, K.W, Amrane, S, Bouaziz, S, Xu, W, Mu, Y, Patel, D.J, Luu, K.N, Phan, A.T. | | 登録日 | 2009-02-12 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers
J.Am.Chem.Soc., 131, 2009
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8J6T
 | | Cryo-EM structure of the double CAF-1 bound right-handed Di-tetrasome | | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | | 著者 | Liu, C.P, Yu, Z.Y, Xu, R.M. | | 登録日 | 2023-04-26 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
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