1FDG
BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX)
Summary for 1FDG
Entry DOI | 10.2210/pdb1fdg/pdb |
Related | 1FD5 |
Descriptor | DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), COBALT (II) ION, 1,4-BIS-[2-(2-HYDROXY-ETHYLAMINO)-ETHYLAMINO]-ANTHRAQUINONE, ... (5 entities in total) |
Functional Keywords | high resolution crystal structure, intercalation platform, mad, anticancer drug, drug-dna complex, metal ions, tertiary base pairs, dna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 3968.82 |
Authors | Yang, X.-L.,Robinson, H.,Gao, Y.-G.,Wang, A.H.-J. (deposition date: 2000-07-20, release date: 2000-08-07, Last modification date: 2024-05-22) |
Primary citation | Yang, X.L.,Robinson, H.,Gao, Y.G.,Wang, A.H. Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms. Biochemistry, 39:10950-10957, 2000 Cited by PubMed: 10998231DOI: 10.1021/bi001319z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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