8RPH
 
 | | JanthE from Janthinobacterium sp. HH01,ketobutyryl-ThDP | | 分子名称: | (2~{S})-2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-2-yl]-2-oxidanyl-butanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... | | 著者 | Lanza, L, Leogrande, C, Rabe von Pappenheim, F, Tittmann, K, Mueller, M. | | 登録日 | 2024-01-16 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | | 主引用文献 | Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8RCO
 | | Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution | | 分子名称: | 1,2-ETHANEDIOL, 6-nitronaphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, MYRISTIC ACID, ... | | 著者 | Pomyalov, S, Sidorenko, V.S, Grollman, A.P, Shoham, G. | | 登録日 | 2023-12-06 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin.
J.Biol.Chem., 300, 2024
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7VEL
 | | Crystal structure of Phytolacca americana UGT3 with UDP-2fluoroglucose | | 分子名称: | 1,2-ETHANEDIOL, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Glycosyltransferase, ... | | 著者 | Maharjan, R, Fukuda, Y, Nakayama, T, Nakayama, T, Hamada, H, Ozaki, S, Inoue, T. | | 登録日 | 2021-09-09 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural basis for substrate recognition in the Phytolacca americana glycosyltransferase PaGT3.
Acta Crystallogr D Struct Biol, 78, 2022
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7VEJ
 | | Crystal structure of Phytolacca americana UGT3 with kaempferol and UDP-2fluoroglucose | | 分子名称: | 1,2-ETHANEDIOL, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3,5,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... | | 著者 | Maharjan, R, Fukuda, Y, Nakayama, T, Nakayama, T, Hamada, H, Ozaki, S, Inoue, T. | | 登録日 | 2021-09-09 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural basis for substrate recognition in the Phytolacca americana glycosyltransferase PaGT3.
Acta Crystallogr D Struct Biol, 78, 2022
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8RF3
 | | Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 7G3 refined against the anomalous diffraction data | | 分子名称: | 2-(1-benzothiophen-3-yl)ethanoic acid, Host translation inhibitor nsp1 | | 著者 | Ma, S, Damfo, S, Mykhaylyk, V, Kozielski, F. | | 登録日 | 2023-12-12 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms.
Acta Crystallogr D Struct Biol, 80, 2024
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5CBM
 | | Crystal structure of PfA-M17 with virtual ligand inhibitor | | 分子名称: | (2S)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, CARBONATE ION, GLYCEROL, ... | | 著者 | Ruggeri, C, Drinkwater, N, McGowan, S. | | 登録日 | 2015-07-01 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Plos One, 10, 2015
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7ZBP
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7VSA
 | | E. coli Ribonuclease HI in complex with two Mg2+ | | 分子名称: | GLYCEROL, MAGNESIUM ION, Ribonuclease HI, ... | | 著者 | Liao, Z, Oyama, T. | | 登録日 | 2021-10-26 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography.
Acta Crystallogr D Struct Biol, 78, 2022
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5GW0
 | | Crystal structure of SNX16 PX-Coiled coil | | 分子名称: | Sorting nexin-16 | | 著者 | Xu, J, Liu, J. | | 登録日 | 2016-09-08 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
Structure, 25, 2017
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8V96
 | | GII.14 M7 norovirus protruding domain | | 分子名称: | 1,2-ETHANEDIOL, Capsid protein VP1 | | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | | 登録日 | 2023-12-07 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses.
J.Virol., 98, 2024
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7NJ8
 | | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1007 | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... | | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | | 登録日 | 2021-02-16 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
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8RFF
 | | Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 6A6 refined against the anomalous diffraction data | | 分子名称: | 1,3-benzothiazol-2-amine, Host translation inhibitor nsp1 | | 著者 | Ma, S, Damfo, S, Mykhaylyk, V, Kozielski, F. | | 登録日 | 2023-12-12 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms.
Acta Crystallogr D Struct Biol, 80, 2024
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7N5Z
 | | SARS-CoV-2 Main protease C145S mutant | | 分子名称: | 3C-like proteinase | | 著者 | Noske, G.D, Nakamura, A.M, Gawriljuk, V.O, Lima, G.M.A, Zeri, A.C.M, Nascimento, A.F.Z, Oliva, G, Godoy, A.S. | | 登録日 | 2021-06-07 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process.
J.Mol.Biol., 433, 2021
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7YXV
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8RF4
 | | Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 9D4 refined against the anomalous diffraction data | | 分子名称: | 4-chloranyl-1~{H}-indazol-3-amine, Host translation inhibitor nsp1 | | 著者 | Ma, S, Damfo, S, Mykhaylyk, V, Kozielski, F. | | 登録日 | 2023-12-12 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | | 主引用文献 | High-confidence placement of low-occupancy fragments into electron density using the anomalous signal of sulfur and halogen atoms.
Acta Crystallogr D Struct Biol, 80, 2024
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7VV9
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5U5L
 | | X-ray Crystal Structure of the PPARgamma Ligand Binding Domain in Complex with Rivoglitazone | | 分子名称: | (5S)-5-({4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma | | 著者 | Bruning, J.B, Rajapaksha, H, Wegener, K, Bhatia, H. | | 登録日 | 2016-12-06 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | X-ray crystal structure of rivoglitazone bound to PPAR gamma and PPAR subtype selectivity of TZDs.
Biochim. Biophys. Acta, 1861, 2017
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7VVG
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8RPB
 | | Structure of S79 Fab in complex with IgV domain of human PD-L1 | | 分子名称: | CHLORIDE ION, GLYCEROL, Programmed cell death 1 ligand 1, ... | | 著者 | Svensson, A, Kelpsas, V, Laursen, M, Rose, N. | | 登録日 | 2024-01-15 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | | 主引用文献 | Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1.
Mabs, 16, 2024
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8V6T
 | | Crystal structure of EcThsB2 | | 分子名称: | BROMIDE ION, Molecular chaperone Tir | | 著者 | Shi, Y, Masic, V, Mosaiab, T, Goulart, C.C, Hartley-Tassell, L, Sorbello, M, Vasquez, E, Mishra, B.P, Holt, S, Gu, W, Kobe, B, Ve, T. | | 登録日 | 2023-12-02 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structural characterization of macro domain-containing Thoeris antiphage defense systems.
Sci Adv, 10, 2024
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8URF
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7NIX
 | | 14-3-3 sigma with AS160 binding site pT642 | | 分子名称: | 14-3-3 protein sigma, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, MAGNESIUM ION, ... | | 著者 | Wolter, M, Ottmann, C. | | 登録日 | 2021-02-14 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
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7PFB
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8RPL
 | | AMP-forming acetyl-CoA synthetase from Chloroflexota bacterium with bound acetyl AMP | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Acetate--CoA ligase, MAGNESIUM ION, ... | | 著者 | Striska, K, Palm, G.J, Lammers, M. | | 登録日 | 2024-01-16 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule.
Nat Commun, 15, 2024
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6MPQ
 | | 1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514 | | 分子名称: | (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, Beta-lactamase, CHLORIDE ION | | 著者 | van den Akker, F, Kumar, V. | | 登録日 | 2018-10-08 | | 公開日 | 2019-02-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent.
MBio, 10, 2019
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