5U5L

X-ray Crystal Structure of the PPARgamma Ligand Binding Domain in Complex with Rivoglitazone

Summary for 5U5L

Entry DOI	10.2210/pdb5u5l/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (5S)-5-({4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione (3 entities in total)
Functional Keywords	nuclear receptor, peroxisome proliferator activated receptor, rivoglitazone, tzd, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	62813.92
Authors	Bruning, J.B.,Rajapaksha, H.,Wegener, K.,Bhatia, H. (deposition date: 2016-12-06, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Rajapaksha, H.,Bhatia, H.,Wegener, K.,Petrovsky, N.,Bruning, J.B. X-ray crystal structure of rivoglitazone bound to PPAR gamma and PPAR subtype selectivity of TZDs. Biochim. Biophys. Acta, 1861:1981-1991, 2017 Cited by PubMed: 28499821 DOI: 10.1016/j.bbagen.2017.05.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation