PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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8E8H	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 300s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E85	Human DNA polymerase eta-DNA-rG-ended primer-dGMPNPP ternary mismatch complex with Mn2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*AP*TP*TP*CP*TP*GP*AP*CP*GP*CP*T)-3'), DNA polymerase eta, ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E8F	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 120s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
8E8E	Human DNA polymerase eta-DNA-rU-ended primer ternary mismatch complex:reaction with 10 mM Mn2+ for 90s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-08-25 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. J.Biol.Chem., 299, 2023
2WRM	Identification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design 分子名称: (3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC ACID, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S. 登録日 2009-09-01 公開日 2010-09-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Identification of Novel Allosteric Inhibitors of Hepatitis C Virus Ns5B Polymerase Thumb Domain (Site II) by Structure-Based Design To be Published
5UH5	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 3 nt of RNA 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-10 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.746 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
8UMV	Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with narrow PCNA opening state I (state 5) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-18 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
8UN0	Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with cracked and closed PCNA (state 7) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-18 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
8UMY	Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with narrow PCNA opening state II (state 6) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-18 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
8UMW	Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex in the five-subunit binding state (state 4) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-18 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
4WKR	LaRP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332) 分子名称: 7SK GGHP4 (300-332), La-related protein 7 著者 Uchikawa, E, Natchiar, K.S, Han, X, Proux, F, Roblin, P, Zhang, E, Durand, A, Klaholz, B.P, Dock-Bregeon, A.-C. 登録日 2014-10-03 公開日 2015-03-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. Nucleic Acids Res., 43, 2015
1A4P	P11 (S100A10), LIGAND OF ANNEXIN II 分子名称: S100A10 著者 Rety, S, Sopkova, J, Renouard, M, Osterloh, D, Gerke, V, Russo-Marie, F, Lewit-Bentley, A. 登録日 1998-01-30 公開日 1998-05-27 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The crystal structure of a complex of p11 with the annexin II N-terminal peptide. Nat.Struct.Biol., 6, 1999
1LV5	Crystal Structure of the Closed Conformation of Bacillus DNA Polymerase I Fragment Bound to DNA and dCTP 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*GP*TP*CP*GP*CP*TP*GP*AP*TP*CP*CP*G)-3', 5'-D(*GP*GP*AP*TP*CP*AP*GP*CP*GP*A)-3', ... 著者 Johnson, S.J, Taylor, J.S, Beese, L.S. 登録日 2002-05-24 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations Proc.Natl.Acad.Sci.USA, 100, 2003
7OMG	Crystal structure of KOD DNA Polymerase in a ternary complex with an Uracil containing template 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ... 著者 Betz, K, Kropp, H.M, Diederichs, K, Marx, A. 登録日 2021-05-22 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase. Chembiochem, 22, 2021
7OMB	Crystal structure of KOD DNA Polymerase in a ternary complex with a p/t duplex containing an extended 5' single stranded template overhang 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, ... 著者 Betz, K, Kropp, H.M, Diederichs, K, Marx, A. 登録日 2021-05-21 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase. Chembiochem, 22, 2021
4EXT	Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta 分子名称: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, peptide from DNA polymerase zeta catalytic subunit 著者 Liu, D.N, Ryu, K.S, Ko, J.S, Choi, B.S. 登録日 2012-05-01 公開日 2013-05-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Insights into the scaffold mechanism of human Rev1 in translesional synthesis revealed by structural studies on its polymerase-interacting domain To be Published
4FJO	Structure of the Rev1 CTD-Rev3/7-Pol kappa RIR complex 分子名称: DNA polymerase kappa, DNA polymerase zeta catalytic subunit, DNA repair protein REV1, ... 著者 Wojtaszek, J, Lee, C.-J, Zhou, P. 登録日 2012-06-11 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.718 Å) 主引用文献 Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric Pol zeta and Pol kappa J.Biol.Chem., 287, 2012
5UH6	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 2ntRNA in complex with Rifampin 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.837 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
5UH9	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 2nt RNA 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.402 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
5UHC	Crystal structure of Mycobacterium tuberculosis transcription initiation complex containing 3nt RNA in complex with Rifampin 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.796 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
7V04	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide 分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-05-09 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
3T72	PhoB(E)-Sigma70(4)-(RNAP-Betha-flap-tip-helix)-DNA Transcription Activation Sub-Complex 分子名称: PHO BOX DNA (STRAND 1), PHO BOX DNA (STRAND 2), Phosphate regulon transcriptional regulatory protein phoB, ... 著者 Blanco, A.G, Canals, A, Bernues, J, Sola, M, Coll, M. 登録日 2011-07-29 公開日 2011-09-21 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (4.33 Å) 主引用文献 The structure of a transcription activation subcomplex reveals how sigma (70) is recruited to PhoB promoters. Embo J., 30, 2011
2FO1	Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA 分子名称: 5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3', 5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3', Lin-12 and glp-1 phenotype protein 1, ... 著者 Wilson, J.J, Kovall, R.A. 登録日 2006-01-12 公開日 2006-03-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell(Cambridge,Mass.), 124, 2006
5T2T	Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001 分子名称: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, CHLORIDE ION, GLYCEROL, ... 著者 Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. 登録日 2016-08-24 公開日 2017-09-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.967 Å) 主引用文献 Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
3QIP	Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine 分子名称: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5,6-dihydroxy-2-[(2-phenyl-1H-indol-3-yl)methyl]pyrimidine-4-carboxylic acid, CHLORIDE ION, ... 著者 Lansdon, E.B, Kirschberg, T.A. 登録日 2011-01-27 公開日 2011-04-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.0926 Å) 主引用文献 Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011

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