7V04

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide

Summary for 7V04

Entry DOI	10.2210/pdb7v04/pdb
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide, ... (4 entities in total)
Functional Keywords	drug discovery, metal-binding pharmacophore, isosteres, influenza endonuclease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Influenza A virus (A/California/04/2009(H1N1))
Total number of polymer chains	1
Total formula weight	22677.32
Authors	Kohlbrand, A.J.,Stokes, R.W.,Karges, J.,Seo, H.,Sankaran, B.,Cohen, S.M. (deposition date: 2022-05-09, release date: 2022-12-21, Last modification date: 2023-10-25)
Primary citation	Stokes, R.W.,Kohlbrand, A.J.,Seo, H.,Sankaran, B.,Karges, J.,Cohen, S.M. Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14:75-82, 2023 Cited by PubMed: 36655124 DOI: 10.1021/acsmedchemlett.2c00434 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation