PDB: 226262 件ウェブページステータス検索Chemie searchBIRD

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3M61	Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition 分子名称: Urokinase-type plasminogen activator, upain-1 W3A 著者 Jiang, L, Yuan, C, Wind, T, Andreasen, P.A, Chen, L, Meehan, E.J, Huang, M. 登録日 2010-03-15 公開日 2010-04-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition TO BE PUBLISHED
4KAM	X-ray crystal structure of O-acetylhomoserine sulfhydrylase MetC from Mycobacterium marinum ATCC BAA-535 / M 分子名称: O-acetylhomoserine sulfhydrylase MetC, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-04-22 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3D9Z	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties 分子名称: 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R. 登録日 2008-05-28 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48, 2009
5ZTZ	Proteobacterial origin of protein arginine methylation and regulation of Complex I assembly by MidA 分子名称: Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial 著者 Arold, S.T, Swaminathan, K, Hameed, U.F.S. 登録日 2018-05-05 公開日 2018-08-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Proteobacterial Origin of Protein Arginine Methylation and Regulation of Complex I Assembly by MidA. Cell Rep, 24, 2018
4KBN	human dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine 分子名称: 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, AMMONIUM ION, CHLORIDE ION, ... 著者 Lamb, K.M, Anderson, A.C. 登録日 2013-04-23 公開日 2013-10-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase. Biochemistry, 52, 2013
3DCQ	LECB (PA-LII) in complex with the synthetic ligand 2G0 分子名称: (2S)-1-[(2S)-6-amino-2-({[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]acetyl}amino)hexanoyl]-N-[(1S)-1-carbamoyl-3-methylbutyl]pyrrolidine-2-carboxamide, CALCIUM ION, Fucose-binding lectin PA-IIL 著者 Johansson, E.M, Crusz, S.A, Kolomiets, E, Buts, L, Kadam, R.U, Cacciarini, M, Bartels, K.M, Diggle, S.P, Camara, M, Williams, P, Loris, R, Nativi, C, Rosenau, F, Jaeger, K.E, Darbre, T, Reymond, J.L. 登録日 2008-06-04 公開日 2009-01-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chem.Biol., 15, 2008
3M8J	Crystal structure of E.coli FocB at 1.4 A resolution 分子名称: FocB protein 著者 Hultdin, U.W, Huang, S, Sauer-Eriksson, A.E. 登録日 2010-03-18 公開日 2010-08-04 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure of FocB - a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli Febs J., 277, 2010
4W4N	Crystal structure of human Fc at 1.80 A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Caaveiro, J.M.M, Kiyoshi, M, Tsumoto, K. 登録日 2014-08-15 公開日 2015-04-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for binding of human IgG1 to its high-affinity human receptor Fc gamma RI Nat Commun, 6, 2015
3M8Q	HIV-1 RT with AMINOPYRIMIDINE NNRTI 分子名称: 3,5-dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile, Reverse transcriptase/ribonuclease H, p51 RT 著者 Harris, S.F, Villasenor, A. 登録日 2010-03-18 公開日 2010-05-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg.Med.Chem.Lett., 20, 2010
6AC6	Ab initio crystal structure of Selenomethionine labelled Mycobacterium smegmatis Mfd 分子名称: Mycobacterium smegmatis Mfd, SULFATE ION 著者 Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. 登録日 2018-07-25 公開日 2019-08-28 実験手法 X-RAY DIFFRACTION (2.989 Å) 主引用文献 Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
3DB6	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902 分子名称: 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea, Polo-like kinase 1 著者 Elling, R.A, Fucini, R.V, Zhu, J, Barr, K.J, Romanowski, M.J. 登録日 2008-05-30 公開日 2008-08-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme. Acta Crystallogr.,Sect.F, 64, 2008
3M6O	Crystal structure of Arabidopsis thaliana peptide deformylase 1B (AtPDF1B) 分子名称: Peptide deformylase 1B, ZINC ION 著者 Fieulaine, S, Meinnel, T, Giglione, C. 登録日 2010-03-16 公開日 2011-03-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis Plos Biol., 9, 2011
4ULX	Crystal structure of ancestral thioredoxin, relative to the last common ancestor of the Cyanobacterial, Deinococcus and Thermus groups, LPBCA-L89K mutant. 分子名称: CHLORIDE ION, LPBCA-L89K THIOREDOXIN 著者 Gavira, J.A, Risso, V.A, Ibarra-Molero, B, Sanchez-Ruiz, J.M. 登録日 2014-05-14 公開日 2014-11-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences Throughout Evolutionary History. Mol.Biol.Evol., 32, 2015
4KC9	Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism 分子名称: E3 ubiquitin-protein ligase ARIH1, ZINC ION 著者 Duda, D.M, Olszewski, J.L, Schulman, B.A. 登録日 2013-04-24 公開日 2013-05-29 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.603 Å) 主引用文献 Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
3DBE	Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 557 分子名称: 3'-chloro-5'-[6-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-3-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]biphenyl-2-carboxamide, Polo-like kinase 1 著者 Elling, R.A, Barr, K.J, Romanowski, M.J. 登録日 2008-05-31 公開日 2008-10-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3DBS	Structure of PI3K gamma in complex with GDC0941 分子名称: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Wiesmann, C, Ultsch, M. 登録日 2008-06-02 公開日 2008-06-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer J.Med.Chem., 51, 2008
3M7N	archaeoglobus fulgidus exosome with RNA bound to the active site 分子名称: 5'-R(*C*UP*CP*CP*CP*C)-3', Probable exosome complex exonuclease 1, Probable exosome complex exonuclease 2, ... 著者 Hartung, S, Hopfner, K.-P. 登録日 2010-03-16 公開日 2010-04-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Quantitative analysis of processive RNA degradation by the archaeal RNA exosome Nucleic Acids Res., 38, 2010
3M9B	Crystal structure of the amino terminal coiled coil domain and the inter domain of the Mycobacterium tuberculosis proteasomal ATPase Mpa 分子名称: Proteasome-associated ATPase 著者 Li, H, Wang, T. 登録日 2010-03-21 公開日 2010-10-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.94 Å) 主引用文献 Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nat.Struct.Mol.Biol., 17, 2010
4KCH	Structure of neuronal nitric oxide synthase heme domain in complex with N,N'-([1,1'-biphenyl]-3,3'-diyl)bis(thiophene-2-carboximidamide) 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N,N'-biphenyl-3,3'-diyldithiophene-2-carboximidamide, ... 著者 Li, H, Poulos, T.L. 登録日 2013-04-24 公開日 2014-02-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J.Med.Chem., 57, 2014
3DDT	Crystal structure of the B2 box from MuRF1 in dimeric state 分子名称: E3 ubiquitin-protein ligase TRIM63, ZINC ION 著者 Mayans, O, Mrosek, M. 登録日 2008-06-06 公開日 2008-10-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold Biochemistry, 47, 2008
4KDD	Structure of Mycobacterium tuberculosis ribosome recycling factor in presence of detergent 分子名称: CADMIUM ION, DECYL-BETA-D-MALTOPYRANOSIDE, Ribosome-recycling factor 著者 Selvaraj, M, Govindan, A, Seshadri, A, Dubey, B, Varshney, U, Vijayan, M. 登録日 2013-04-24 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular flexibility of Mycobacterium tuberculosis ribosome recycling factor and its functional consequences: an exploration involving mutants. J.Biosci., 38, 2013
3MB9	Human Aldose Reductase mutant T113A complexed with Zopolrestat 分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Koch, C, Heine, A, Klebe, G. 登録日 2010-03-25 公開日 2011-03-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase Biochim.Biophys.Acta, 1810, 2011
3MBL	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP 分子名称: 5-acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Dougan, D.R, Mol, C.D. 登録日 2010-03-25 公開日 2010-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
4KMM	M76H variant of human ferrochelatase 分子名称: CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Lanzilotta, W.N, Medlock, A.E. 登録日 2013-05-08 公開日 2014-05-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 M76H variant of human ferrochelatase To be Published
3DCS	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties 分子名称: Carbonic anhydrase 2, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION 著者 Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R. 登録日 2008-06-04 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48, 2009

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