3MB9
Human Aldose Reductase mutant T113A complexed with Zopolrestat
Summary for 3MB9
Entry DOI | 10.2210/pdb3mb9/pdb |
Related | 2FZ8 2FZ9 3LEN 3LQG 3LQL 3M0I |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (4 entities in total) |
Functional Keywords | t113a mutant, oxidoreductase, tim barrel, nadp, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37031.09 |
Authors | |
Primary citation | Koch, C.,Heine, A.,Klebe, G. Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase Biochim.Biophys.Acta, 1810:879-887, 2011 Cited by PubMed: 21684320DOI: 10.1016/j.bbagen.2011.06.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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