PDB: 30805 件ウェブページステータス検索Chemie searchBIRD

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8PJ7	MLLT3 in complex with compound PFI-6 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Raux, B, Diaz-Saez, L, Huber, K.V.M, Fedorov, O, Owen, D.R, Londregan, A.T, Bountra, C, Edwards, A, Arrowsmith, C. 登録日 2023-06-22 公開日 2023-11-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg.Med.Chem.Lett., 98, 2023
5C2D	K428A mutant gp2c of large terminase subunit from bacteriophage sf6 with calcium 分子名称: CALCIUM ION, Gene 2 protein 著者 Zhao, H, Tang, L. 登録日 2015-06-15 公開日 2015-10-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism. Nucleic Acids Res., 43, 2015
6P91	Structure of Lassa virus glycoprotein bound to Fab 18.5C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 18.5C Antibody heavy chain, ... 著者 Saphire, E.O, Hastie, K.M. 登録日 2019-06-09 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization. Cell, 178, 2019
6AUE	Artificial Metalloproteins Containing a Co4O4 Active Site - 2xm-S112Y-b 分子名称: N-biotin-C-Co4(mu3-O)4(OAc)(Py)4(H2O)3-beta-alanine, Streptavidin 著者 Olshansky, L, Vallapurakal, J, Huerta-Lavorie, R, Nguyen, A.I, Tilley, T.D, Borovik, A.S. 登録日 2017-08-31 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Artificial Metalloproteins Containing Co J. Am. Chem. Soc., 140, 2018
5C2L	Magnesium soaked into the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD) 分子名称: Anthranilate phosphoribosyltransferase, IMIDAZOLE, MAGNESIUM ION 著者 Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) 登録日 2015-06-16 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.009 Å) 主引用文献 Binding and mimicking of the phosphate-rich substrate, PRPP To Be Published
6PNZ	The structure of the Aspartate Transcarbamoylase trimer from Staphylococcus aureus complexed with PALA at 2.27 Resolution. 分子名称: Aspartate carbamoyltransferase, N-(PHOSPHONACETYL)-L-ASPARTIC ACID 著者 Edwards, B.F.P, Evans, D.R, Patel, C. 登録日 2019-07-03 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 The structure of the Aspartate Transcarbamoylase trimer from Staphylococcus aureus complexed with PALA at 2.27 Resolution. To Be Published
7SNR	2.00A Resolution Structure of NanoLuc Luciferase 分子名称: ACETATE ION, CITRATE ANION, Oplophorus-luciferin 2-monooxygenase catalytic subunit 著者 Lovell, S, Mehzabeen, N, Battaile, K.P, Wood, M.G, Encell, L.P, Wood, K.V. 登録日 2021-10-28 公開日 2022-11-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2.00A Resolution Structure of NanoLuc Luciferase To be published
6MC6	Crystal structure of PprA filament from Deinococcus radiodurans 分子名称: DNA repair protein PprA 著者 Szabla, R, Junop, M.S, Wood, K. 登録日 2018-08-30 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.747 Å) 主引用文献 Crystal structure of PprA from Deinococcus radiodurans To Be Published
7O4W	Crystal structure of diphtheria toxin mutant CRM197 with a disulphide bond replaced by a Cys-Acetone-Cys bridge 分子名称: 1,2-ETHANEDIOL, 1-hydroxypropan-2-one, ACETATE ION, ... 著者 Veggi, D, Dello Iacono, L. 登録日 2021-04-07 公開日 2022-04-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.03002071 Å) 主引用文献 Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates. Chem Sci, 13, 2022
6VBZ	Crystal structure of the rat MLKL pseudokinase domain 分子名称: MANGANESE (II) ION, Mixed lineage kinase domain-like pseudokinase 著者 Davies, K.A, Czabotar, P.E. 登録日 2019-12-19 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.192 Å) 主引用文献 Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11, 2020
7SSI	CRYSTAL STRUCTURE OF THE DESK:DESR-Q10A COMPLEX IN THE PHOSPHOTRANSFER STATE 分子名称: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Sensor histidine kinase DesK, ... 著者 Trajtenberg, F, Buschiazzo, A. 登録日 2021-11-11 公開日 2022-11-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis. Sci.Signal., 16, 2023
6POA	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-(3-(Aminomethyl)-4-(pyridin-3-ylmethoxy)phenyl)-4-methylquinolin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-{3-(aminomethyl)-4-[(pyridin-3-yl)methoxy]phenyl}-4-methylquinolin-2-amine, Nitric oxide synthase, ... 著者 Li, H, Poulos, T.L. 登録日 2019-07-03 公開日 2020-04-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.809 Å) 主引用文献 First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020
6AV0	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-(3-(methylamino)propyl)benzonitrile 分子名称: 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-[3-(methylamino)propyl]benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 LI, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
6AV1	Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 6-(3-(3-(Dimethylamino)propyl)-5-fluorophenethyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine, Nitric oxide synthase, ... 著者 Li, H, Poulos, T.L. 登録日 2017-09-01 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. J. Med. Chem., 60, 2017
6UVO	Structure of antibody 3G12 bound to the central conserved domain of RSV G 分子名称: 3G12 Fab Heavy chain, 3G12 Fab light chain, Major surface glycoprotein G 著者 Fedechkin, S.O, George, N.L, Nunez Castrejon, A.M, Dillen, J, Kauvar, L.M, DuBois, R.M. 登録日 2019-11-03 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes. J.Virol., 94, 2020
7O05	Crystal structure of SARS-CoV-2 N-CTD 分子名称: Nucleoprotein 著者 Ciges-Tomas, J.R, Vilar, M. 登録日 2021-03-25 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Identification of a guanine-specific pocket in the protein N of SARS-CoV-2. Commun Biol, 5, 2022
7SSJ	Crystal structure of the DesK-DesR complex in the phosphatase state 分子名称: BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... 著者 Trajtenberg, F, Buschiazzo, A. 登録日 2021-11-11 公開日 2022-11-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis. Sci.Signal., 16, 2023
7WOX	PPARgamma antagonist (MMT-160)- PPARgamma LBD complex 分子名称: N-[[5-(3-phenylprop-2-ynoylamino)-2-propoxy-phenyl]methyl]-4-pyrimidin-2-yl-benzamide, Peroxisome proliferator-activated receptor gamma 著者 Yoshizawa, M, Aoyama, T, Itoh, T, Miyachi, H. 登録日 2022-01-22 公開日 2022-04-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Arylalkynyl amide-type peroxisome proliferator-activated receptor gamma (PPAR gamma )-selective antagonists covalently bind to the PPAR gamma ligand binding domain with a unique binding mode. Bioorg.Med.Chem.Lett., 64, 2022
6MD5	Crystal structure of zebrafish Vps26A 分子名称: Vacuolar protein sorting-associated protein 26A 著者 Collins, B.M, Leneva, N. 登録日 2018-09-03 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 TBA To Be Published
6MFN	Human Argonaute2-miR-27a bound to HSUR1 target RNA 分子名称: PHENOL, Protein argonaute-2, RNA (5'-R(P*UP*CP*UP*GP*UP*GP*AP*UP*AP*A)-3'), ... 著者 Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2018-09-11 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
6UW7	The crystal structure of FbiA from Mycobacterium smegmatis, Dehydro-F420-0 bound form 分子名称: 2-[oxidanyl-[(2~{R},3~{S},4~{S})-2,3,4-tris(oxidanyl)-5-[2,4,8-tris(oxidanylidene)-1,9-dihydropyrimido[4,5-b]quinolin-10-yl]pentoxy]phosphoryl]oxyprop-2-enoic acid, CALCIUM ION, GLYCEROL, ... 著者 Grinter, R, Gillett, D, Cordero, P.R.F, Izore, T, Greening, C. 登録日 2019-11-04 公開日 2020-05-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.342 Å) 主引用文献 Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria. mSystems, 5, 2020
8Q5G	Crystal structure of nitroreductase from Bacillus tequilensis with covalent FMN 分子名称: FLAVIN MONONUCLEOTIDE, NAD(P)H-dependent oxidoreductase 著者 Rozeboom, H.J, Fraaije, M.W. 登録日 2023-08-09 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor. J.Am.Chem.Soc., 145, 2023
7O36	Crystal Structure of SARS-CoV-2 N-CTD in complex with GTP (II) 分子名称: GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, Nucleoprotein 著者 Ciges-Tomas, J.R, Vilar, M. 登録日 2021-04-01 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Identification of a guanine-specific pocket in the protein N of SARS-CoV-2. Commun Biol, 5, 2022
6AVZ	Crystal structure of the HopQ-CEACAM3 WT complex 分子名称: CALCIUM ION, Carcinoembryonic antigen-related cell adhesion molecule 3, HopQ, ... 著者 Bonsor, D.A, Sundberg, E.J. 登録日 2017-09-05 公開日 2018-05-16 最終更新日 2018-07-11 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 TheHelicobacter pyloriadhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA. EMBO J., 37, 2018
8DEY	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-06-21 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023

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