PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

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7S0X	Fab352 in complex with the C-terminal alphaTSR domain of P. falciparum 分子名称: Circumsporozoite protein, Fab352 heavy chain, Fab352 light chain 著者 Pholcharee, T, Oyen, D, Wilson, I.A. 登録日 2021-08-31 公開日 2022-03-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. Plos Pathog., 18, 2022
6WAB	Crystal structure of human galectin-4 C-terminal carbohydrate recognition domain in complex with galactose derivative 分子名称: 2,6-anhydro-1,4-dideoxy-1-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-4-(4-phenyl-1H-1,2,3-triazol-1-yl)-D-glycero-L-manno-heptitol, GLYCEROL, Galectin-4 著者 Go, R.M, Kishor, C, Blanchard, H. 登録日 2020-03-25 公開日 2021-04-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Crystal structure of human galectin-4 C-terminal carbohydrate recognition domain in complex with galactose derivative To Be Published
6T6I	Crystal Structure of the C-terminal domain of the HIV-1 Integrase (subtype A2) 分子名称: NICKEL (II) ION, Pol protein 著者 Ruff, M, Negroni, M. 登録日 2019-10-18 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases. J.Virol., 94, 2020
6T6E	Crystal Structure of the C-terminal domain of the HIV-1 Integrase (PNL4-3) 分子名称: NICKEL (II) ION, Pol protein 著者 Ruff, M, Negroni, M. 登録日 2019-10-18 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.302 Å) 主引用文献 NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases. J.Virol., 94, 2020
1Y7N	Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha 分子名称: Amyloid beta A4 precursor protein-binding family A member 1 著者 Duquesne, A.E, de Ruijter, M, Brouwer, J, Drijfhout, J.W, Nabuurs, S.B, Spronk, C.A.E.M, Vuister, G.W, Ubbink, M, Canters, G.W. 登録日 2004-12-09 公開日 2005-11-22 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase J.Biomol.Nmr, 32, 2005
8P9Y	SARS-CoV-2 S protein S:D614G mutant in 3-down with binding site of an entry inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... 著者 Adhav, A, Forcada-Nadal, A, Marco-Marin, C, Lopez-Redondo, M.L, Llacer, J.L. 登録日 2023-06-06 公開日 2023-09-27 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein. J.Med.Chem., 66, 2023
8P99	SARS-CoV-2 S-protein:D614G mutant in 1-up conformation 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1,Spike glycoprotein 著者 Adhav, A, Forcada-Nadal, A, Marco-Marin, C, Lopez-Redondo, M.L, Llacer, J.L. 登録日 2023-06-05 公開日 2023-09-27 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein. J.Med.Chem., 66, 2023
5GRN	Crystal structure of PDGFRA in Complex with WQ-C-159 分子名称: CHLORIDE ION, N-[2-(dimethylamino)ethyl]-N-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide, Platelet-derived growth factor receptor alpha 著者 Yan, X.E, Yun, C.H. 登録日 2016-08-11 公開日 2017-08-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Crystal Structure of PDGFRA in Complex with WQ-C-159 To Be Published
8J2B	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ and malonate 分子名称: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8S4X	Tankyrase 2 in complex with a quinazolin-4-one inhibitor 分子名称: 8-[bis(oxidanyl)amino]-2-(4-~{tert}-butylphenyl)-3~{H}-quinazolin-4-one, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... 著者 Bosetti, C, Lehtio, L. 登録日 2024-02-22 公開日 2025-03-05 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors. Eur.J.Med.Chem., 288, 2025
8J2A	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ 分子名称: GLYCEROL, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2D	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ 分子名称: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2C	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R 分子名称: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2E	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ and malonate 分子名称: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
5OGS	Crystal structure of human AND-1 SepB domain 分子名称: MALONATE ION, WD repeat and HMG-box DNA-binding protein 1 著者 Pellegrini, L, Simon, A.C. 登録日 2017-07-13 公開日 2017-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.503 Å) 主引用文献 The human CTF4-orthologue AND-1 interacts with DNA polymerase alpha /primase via its unique C-terminal HMG box. Open Biol, 7, 2017
5KTX	CREBBP bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone) 分子名称: 1,2-ETHANEDIOL, 1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone, CREB-binding protein, ... 著者 Murray, J.M, Noland, C. 登録日 2016-07-12 公開日 2016-11-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. J. Med. Chem., 59, 2016
6FNZ	Crystal Structure of domain-swapped C-terminal domain of human doublecortin 分子名称: Neuronal migration protein doublecortin, possible peptide 著者 Stihle, M, Benz, J, Rudolph, M.G. 登録日 2018-02-05 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Domain swap in the C-terminal ubiquitin-like domain of human doublecortin. Acta Crystallogr D Struct Biol, 74, 2018
8HAW	An auto-activation mechanism of plant non-specific phospholipase C 分子名称: CALCIUM ION, GLYCEROL, Non-specific phospholipase C4, ... 著者 Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. 登録日 2022-10-26 公開日 2023-01-25 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C. Nat Commun, 14, 2023
8JN8	Crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668 分子名称: (2R)-N-cyclopentyl-2-[cyclopropyl(ethanoyl)amino]-2-(4-fluorophenyl)ethanamide, Proto-oncogene tyrosine-protein kinase Src 著者 Zhang, H.M, Luo, C. 登録日 2023-06-06 公開日 2024-06-12 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 The crystal structure of c-Src in complex with covalent inhibitor DC-Srci-6668 To Be Published
8JN9	Crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8 分子名称: N-[(1R)-1-[3,5-bis(fluoranyl)phenyl]-2-(cyclopentylamino)-2-oxidanylidene-ethyl]-N-cyclopropyl-prop-2-enamide, Proto-oncogene tyrosine-protein kinase Src 著者 Zhang, H.M, Luo, C. 登録日 2023-06-06 公開日 2024-06-12 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.724 Å) 主引用文献 The crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8 To Be Published
7B3W	Crystal structure of c-MET bound by compound 4 分子名称: 1,2-ETHANEDIOL, 3-(6-fluoranyl-1~{H}-indazol-4-yl)-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor 著者 Collie, G.W. 登録日 2020-12-01 公開日 2020-12-09 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
7B43	Crystal structure of c-MET bound by compound 9 分子名称: 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor 著者 Collie, G.W. 登録日 2020-12-02 公開日 2020-12-09 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
6SAZ	Cleaved human fetuin-b in complex with crayfish astacin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Astacin, ... 著者 Gomis-Ruth, F.X, Guevara, T, Cuppari, A, Korschgen, H, Schmitz, C, Kuske, M, Yiallouros, I, Floehr, J, Jahnen-Dechent, W, Stocker, W. 登録日 2019-07-18 公開日 2019-10-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases. Sci Rep, 9, 2019
9GFK	human MDM2 complex with stapled foldamer 分子名称: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, Stapled foldamer 著者 Neuville, M, Bourgeais, M, Buratto, J, Saragaglia, C, Bo, L, Mauran, L, Varajao, L, Goudreau, S.R, Kauffmann, B, Thinon, E, Pasco, M, Khatib, A.M. 登録日 2024-08-09 公開日 2025-03-26 最終更新日 2025-04-16 実験手法 X-RAY DIFFRACTION (1.841 Å) 主引用文献 Optimal Stapling of a Helical Peptide-Foldamer Hybrid Using a C-Terminal 4-Mercaptoproline Enhances Protein Surface Recognition and Cellular Activity. Chemistry, 31, 2025
7QCN	Structure of the MUCIN-2 Cterminal domains: vWCN to TIL domains with a C2 symmetry 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-2, ... 著者 Gallego, P, Hansson, G.C. 登録日 2021-11-24 公開日 2023-03-08 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nat Commun, 14, 2023

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