8P9Y

SARS-CoV-2 S protein S:D614G mutant in 3-down with binding site of an entry inhibitor

Summary for 8P9Y

• Entry DOI: 10.2210/pdb8p9y/pdb
• EMDB information: 17578
• Descriptor: Spike protein S1,Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: spike, sars cov-2, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 433656.70

Authors

Adhav, A.,Forcada-Nadal, A.,Marco-Marin, C.,Lopez-Redondo, M.L.,Llacer, J.L. (deposition date: 2023-06-06, release date: 2023-09-27)

• Primary citation: Gargantilla, M.,Frances, C.,Adhav, A.,Forcada-Nadal, A.,Martinez-Gualda, B.,Marti-Mari, O.,Lopez-Redondo, M.L.,Melero, R.,Marco-Marin, C.,Gougeard, N.,Espinosa, C.,Rubio-Del-Campo, A.,Ruiz-Partida, R.,Hernandez-Sierra, M.D.P.,Villamayor-Belinchon, L.,Bravo, J.,Llacer, J.L.,Marina, A.,Rubio, V.,San-Felix, A.,Geller, R.,Perez-Perez, M.J.; C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein.; J.Med.Chem., 66:10432-10457, 2023; PubMed: 37471688; DOI: 10.1021/acs.jmedchem.3c00576

Experimental method

ELECTRON MICROSCOPY (4.3 Å)