4EGJ
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6QKC
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![BU of 6qkc by Molmil](/molmil-images/mine/6qkc) | GluA1/2 In complex with auxiliary subunit gamma-8 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ... | 著者 | Herguedas, B, Garcia-Nafria, J, Greger, I.G. | 登録日 | 2019-01-28 | 公開日 | 2019-03-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
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6S41
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![BU of 6s41 by Molmil](/molmil-images/mine/6s41) | CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455 | 分子名称: | 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 | 著者 | Focken, T, Maskos, K, Griessner, A, Krapp, S. | 登録日 | 2019-06-26 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J.Med.Chem., 62, 2019
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6WYC
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6WZ6
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![BU of 6wz6 by Molmil](/molmil-images/mine/6wz6) | Complex of mutant (K173M) of Pseudomonas 7A Glutaminase-Asparaginase with L-Glu at pH 5. Covalent acyl-enzyme intermediate | 分子名称: | 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutaminase-asparaginase | 著者 | Strzelczyk, P, Zhang, D, Wlodawer, A, Lubkowski, J. | 登録日 | 2020-05-13 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria. Sci Rep, 10, 2020
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6S4G
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![BU of 6s4g by Molmil](/molmil-images/mine/6s4g) | Crystal structure of the omega transaminase from Chromobacterium violaceum in complex with PMP | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ruggieri, F, Campillo Brocal, J.C, Humble, M.S, Walse, B, Logan, D.T, Berglund, P. | 登録日 | 2019-06-27 | 公開日 | 2019-07-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase. Sci Rep, 9, 2019
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6QG3
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![BU of 6qg3 by Molmil](/molmil-images/mine/6qg3) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model B) | 分子名称: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | 著者 | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | 登録日 | 2019-01-10 | 公開日 | 2019-06-26 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (9.4 Å) | 主引用文献 | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6WH9
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![BU of 6wh9 by Molmil](/molmil-images/mine/6wh9) | Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10 | 分子名称: | 1D10 (Fab heavy chain), 1D10 (Fab light chain), KR1, ... | 著者 | Cogan, D.P, Mathews, I.I, Khosla, C. | 登録日 | 2020-04-07 | 公開日 | 2020-09-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. J.Am.Chem.Soc., 142, 2020
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6TER
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![BU of 6ter by Molmil](/molmil-images/mine/6ter) | Crystal structure of a galactokinase from Bifidobacterium infantis in complex with Galactose | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Keenan, T, Parmeggiani, F, Fontenelle, C.Q, Malassis, J, Vendeville, J, Offen, W.A, Both, P, Huang, K, Marchesi, A, Heyam, A, Young, C, Charnock, S, Davies, G.J, Linclau, B, Flitsch, S.L, Fascione, M.A. | 登録日 | 2019-11-12 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides. Cell Chem Biol, 27, 2020
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6TGH
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![BU of 6tgh by Molmil](/molmil-images/mine/6tgh) | SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external aldimine and as non-covalent complex | 分子名称: | D-SERINE, L-Serine, N-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylene], ... | 著者 | Petrillo, G, Hernandez, K, Bujons, J, Clapes, P, Uson, I. | 登録日 | 2019-11-15 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structural insights into nucleophile substrate specificity in variants of N-Serine hydroxymethyltransferase from Streptococcus thermophilus To Be Published
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6TGZ
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![BU of 6tgz by Molmil](/molmil-images/mine/6tgz) | IE1 from human cytomegalovirus | 分子名称: | 55 kDa immediate-early protein 1 | 著者 | Schweininger, J, Muller, Y.A. | 登録日 | 2019-11-18 | 公開日 | 2020-11-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers. Plos Pathog., 17, 2021
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6QG5
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![BU of 6qg5 by Molmil](/molmil-images/mine/6qg5) | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model C) | 分子名称: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | 著者 | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | 登録日 | 2019-01-10 | 公開日 | 2019-06-26 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (10.1 Å) | 主引用文献 | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation. Nat Commun, 10, 2019
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6VSC
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3DUS
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![BU of 3dus by Molmil](/molmil-images/mine/3dus) | Crystal structure of SAG506-01, orthorhombic, twinned, crystal 1 | 分子名称: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ... | 著者 | Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V. | 登録日 | 2008-07-17 | 公開日 | 2008-12-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments. Acta Crystallogr.,Sect.D, 64, 2008
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6THJ
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3I02
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![BU of 3i02 by Molmil](/molmil-images/mine/3i02) | Crystal structure of S54-10 antibody in complex with antigen Kdo(2.4)Kdo(2.4)Kdo | 分子名称: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, Immunoglobulin heavy chain, Immunoglobulin light chain | 著者 | Brooks, C.L, Muller-Loennies, S, Borisova, S.N, Brade, L, Kosma, P, Hirama, T, MacKenzie, C.R, Brade, H, Evans, S.V. | 登録日 | 2009-06-24 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition Biochemistry, 49, 2010
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6VNU
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![BU of 6vnu by Molmil](/molmil-images/mine/6vnu) | X-ray Crystal Structure of Ruthenocenyl-7-Aminocephalosporanic Acid Covalent Acyl-Enzyme Complex with CTX-M-14 E166A Beta-Lactamase | 分子名称: | Beta-lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[carboxy(4-carboxy-5-methylidene-5,6-dihydro-2H-1,3-thiazin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Chen, Y. | 登録日 | 2020-01-29 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Metallocenyl 7-ACA Conjugates: Antibacterial Activity Studies and Atomic-Resolution X-ray Crystal Structure with CTX-M beta-Lactamase. Chembiochem, 21, 2020
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3HMY
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![BU of 3hmy by Molmil](/molmil-images/mine/3hmy) | Crystal structure of HCR/T complexed with GT2 | 分子名称: | GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid, SULFATE ION, ... | 著者 | Chen, C, Fu, Z, Kim, J.-J.P, Barbieri, J.T, Baldwin, M.R. | 登録日 | 2009-05-29 | 公開日 | 2009-07-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Gangliosides as high affinity receptors for tetanus neurotoxin. J.Biol.Chem., 284, 2009
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6VUX
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![BU of 6vux by Molmil](/molmil-images/mine/6vux) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT388 | 分子名称: | 2-{[(7S)-4-amino-7-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-[2-(piperidin-1-yl)ethyl]acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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6QKN
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![BU of 6qkn by Molmil](/molmil-images/mine/6qkn) | Structure of the azide-inhibited form of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae | 分子名称: | AZIDE ION, CALCIUM ION, Cytochrome-c peroxidase, ... | 著者 | Carvalho, A.L, Romao, M.J, Pauleta, S, Nobrega, C. | 登録日 | 2019-01-29 | 公開日 | 2020-02-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of the mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae To Be Published
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6QKS
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![BU of 6qks by Molmil](/molmil-images/mine/6qks) | Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - Tyr219Phe - Apo | 分子名称: | CHLORIDE ION, Fluoroacetate dehalogenase | 著者 | Mehrabi, P, Kim, T.H, Prosser, R.S, Pai, E.F. | 登録日 | 2019-01-30 | 公開日 | 2019-06-26 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Substrate-Based Allosteric Regulation of a Homodimeric Enzyme. J.Am.Chem.Soc., 141, 2019
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6QLA
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![BU of 6qla by Molmil](/molmil-images/mine/6qla) | CRYSTAL STRUCTURE OF THE PMGL2 ESTERASE (point mutant 1) FROM PERMAFROST METAGENOMIC LIBRARY | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Boyko, K.M, Garsia, D, Nikolaeva, A.Y, Korzhenevskiy, D.A, Kryukova, M.V, Petrovskaya, L.E, Novototskaya-Vlasova, K.A, Rivkina, E.M, Dolgikh, D.A, Kirpichnikov, M.P, Popov, V.O. | 登録日 | 2019-01-31 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine. Plos One, 15, 2020
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4IXV
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![BU of 4ixv by Molmil](/molmil-images/mine/4ixv) | Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-) | 分子名称: | Arginase-2, mitochondrial, BENZAMIDINE, ... | 著者 | Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D, Beckett, P, Van Zandt, M.C, Ji, M.K, Ryder, T, Jagdmann, R, Andreoli, M, Olczak, J, Mazur, M, Czestkowski, W, Piotrowska, W, Schroeter, H, Golebiowski, A, Podjarny, A. | 登録日 | 2013-01-28 | 公開日 | 2013-12-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg.Med.Chem.Lett., 23, 2013
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4IYF
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6VZ8
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