5E2M
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![BU of 5e2m by Molmil](/molmil-images/mine/5e2m) | Crystal structure of human carbonic anhydrase isozyme I with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide | 分子名称: | 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, ACETATE ION, Carbonic anhydrase 1, ... | 著者 | Manakova, E, Smirnov, A, Grazulis, S. | 登録日 | 2015-10-01 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases. ChemMedChem, 12, 2017
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4Q30
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![BU of 4q30 by Molmil](/molmil-images/mine/4q30) | |
8AHC
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![BU of 8ahc by Molmil](/molmil-images/mine/8ahc) | Crystal structure of the BRD9 bromodomain with BI-7189 | 分子名称: | Bromodomain-containing protein 9, [2,6-dimethoxy-4-(1,2,5-trimethyl-6-oxidanylidene-pyridin-3-yl)phenyl]methyl-dimethyl-azanium | 著者 | Bader, G, Boettcher, J, Weiss-Puxbaum, A. | 登録日 | 2022-07-21 | 公開日 | 2023-06-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.504 Å) | 主引用文献 | Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. Chemmedchem, 18, 2023
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4XZN
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![BU of 4xzn by Molmil](/molmil-images/mine/4xzn) | Crystal structure of the methylated K125R/V301L AKR1B10 Holoenzyme | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Podjarny, A. | 登録日 | 2015-02-04 | 公開日 | 2015-11-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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4XZL
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![BU of 4xzl by Molmil](/molmil-images/mine/4xzl) | Crystal structure of human AKR1B10 complexed with NADP+ and JF0049 | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Dominguez, M, de Lera, A.R, Farres, J, Pares, X, Podjarny, A. | 登録日 | 2015-02-04 | 公開日 | 2015-11-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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4XZM
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![BU of 4xzm by Molmil](/molmil-images/mine/4xzm) | Crystal structure of the methylated wild-type AKR1B10 holoenzyme | 分子名称: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Podjarny, A. | 登録日 | 2015-02-04 | 公開日 | 2015-11-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. Chemmedchem, 10, 2015
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6VNQ
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![BU of 6vnq by Molmil](/molmil-images/mine/6vnq) | |
2ADO
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![BU of 2ado by Molmil](/molmil-images/mine/2ado) | Crystal Structure Of The Brct Repeat Region From The Mediator of DNA damage checkpoint protein 1, MDC1 | 分子名称: | Mediator of DNA damage checkpoint protein 1 | 著者 | Lee, M.S, Edwards, R.A, Thede, G.L, Glover, J.N. | 登録日 | 2005-07-20 | 公開日 | 2005-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure of the BRCT Repeat Domain of MDC1 and Its Specificity for the Free COOH-terminal End of the {gamma}-H2AX Histone Tail. J.Biol.Chem., 280, 2005
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4OYO
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![BU of 4oyo by Molmil](/molmil-images/mine/4oyo) | |
4OZ3
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![BU of 4oz3 by Molmil](/molmil-images/mine/4oz3) | |
4OYB
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![BU of 4oyb by Molmil](/molmil-images/mine/4oyb) | Crystal Structure Analysis of the solAC | 分子名称: | Adenylate cyclase type 10, GLYCEROL, ethyl 2-[3-[(4-azanyl-1,2,5-oxadiazol-3-yl)carbonyl]phenoxy]ethanoate | 著者 | Vinkovic, M. | 登録日 | 2014-02-11 | 公開日 | 2014-04-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OYP
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![BU of 4oyp by Molmil](/molmil-images/mine/4oyp) | Human solAC Complexed with 1-Benzofuran-2-carboxylic acid | 分子名称: | 1-benzofuran-2-carboxylic acid, Adenylate cyclase type 10, CHLORIDE ION | 著者 | Vinkovic, M. | 登録日 | 2014-02-12 | 公開日 | 2014-04-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OZ2
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![BU of 4oz2 by Molmil](/molmil-images/mine/4oz2) | Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole | 分子名称: | 4-(4-fluorophenyl)-3-methyl-1H-pyrazole, Adenylate cyclase type 10, CHLORIDE ION, ... | 著者 | Vinkovic, M. | 登録日 | 2014-02-13 | 公開日 | 2014-04-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4P90
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2ZN7
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![BU of 2zn7 by Molmil](/molmil-images/mine/2zn7) | CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes | 分子名称: | 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xu, W, Wu, J. | 登録日 | 2008-04-22 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24 Chemmedchem, 3, 2008
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2MOF
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![BU of 2mof by Molmil](/molmil-images/mine/2mof) | Structural insights of TM domain of LAMP-2A in DPC micelles | 分子名称: | Lysosome-associated membrane glycoprotein 2 | 著者 | Tjandra, N, Rout, A. | 登録日 | 2014-04-25 | 公開日 | 2014-10-29 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy. J.Biol.Chem., 289, 2014
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2MOM
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![BU of 2mom by Molmil](/molmil-images/mine/2mom) | Structural insights of TM domain of LAMP-2A in DPC micelles | 分子名称: | Lysosome-associated membrane glycoprotein 2 | 著者 | Tjandra, N, Rout, A. | 登録日 | 2014-04-27 | 公開日 | 2014-10-29 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy. J.Biol.Chem., 289, 2014
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1ZGA
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![BU of 1zga by Molmil](/molmil-images/mine/1zga) | Crystal structure of isoflavanone 4'-O-methyltransferase complexed with (+)-6a-hydroxymaackiain | 分子名称: | (6AR,12AR)-6H-[1,3]DIOXOLO[5,6][1]BENZOFURO[3,2-C]CHROMENE-3,6A(12AH)-DIOL, Isoflavanone 4'-O-methyltransferase', S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Liu, C.-J, Deavours, B.E, Richard, S, Ferrer, J.-L, Dixon, R.A, Noel, J.P. | 登録日 | 2005-04-20 | 公開日 | 2006-08-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell, 18, 2006
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2ZMM
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![BU of 2zmm by Molmil](/molmil-images/mine/2zmm) | Crystal structure of PTP1B-inhibitor complex | 分子名称: | 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(methylcarbamoyl)amino]phenyl}thiophene-2-carboxylic acid, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Xu, W, Wu, J. | 登録日 | 2008-04-19 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24 Chemmedchem, 3, 2008
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5UA4
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![BU of 5ua4 by Molmil](/molmil-images/mine/5ua4) | |
5UA5
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![BU of 5ua5 by Molmil](/molmil-images/mine/5ua5) | |
5WOS
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4YIH
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![BU of 4yih by Molmil](/molmil-images/mine/4yih) | Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU | 分子名称: | 1-{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-D-threo-pentofuranosyl}-5-[(E)-2-phosphonoethenyl]pyrimidine-2,4(1H,3H)-dione, 5'(3')-deoxyribonucleotidase, cytosolic type, ... | 著者 | Pachl, P, Rezacova, P, Brynda, J. | 登録日 | 2015-03-02 | 公開日 | 2015-09-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor Medchemcomm, 6, 2015
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5Z9E
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5Z9N
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![BU of 5z9n by Molmil](/molmil-images/mine/5z9n) | |