8AHC

Crystal structure of the BRD9 bromodomain with BI-7189

Summary for 8AHC

Entry DOI	10.2210/pdb8ahc/pdb
Related	8AG2
Descriptor	Bromodomain-containing protein 9, [2,6-dimethoxy-4-(1,2,5-trimethyl-6-oxidanylidene-pyridin-3-yl)phenyl]methyl-dimethyl-azanium (3 entities in total)
Functional Keywords	inhibitor, complex, gene regulation
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	29162.38
Authors	Bader, G.,Boettcher, J.,Weiss-Puxbaum, A. (deposition date: 2022-07-21, release date: 2023-06-21, Last modification date: 2024-02-07)
Primary citation	Martinelli, P.,Schaaf, O.,Mantoulidis, A.,Martin, L.J.,Fuchs, J.E.,Bader, G.,Gollner, A.,Wolkerstorfer, B.,Rogers, C.,Balikci, E.,Lipp, J.J.,Mischerikow, N.,Doebel, S.,Gerstberger, T.,Sommergruber, W.,Huber, K.V.M.,Bottcher, J. Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. Chemmedchem, 18:e202200686-e202200686, 2023 Cited by PubMed: 36649575 DOI: 10.1002/cmdc.202200686 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.504 Å)

Structure validation