8AG2
Crystal structure of the BPTF bromodomain in complex with BI-7190
Summary for 8AG2
Entry DOI | 10.2210/pdb8ag2/pdb |
Descriptor | Nucleosome-remodeling factor subunit BPTF, 5-[3-methoxy-4-[1-(4-methylpiperazin-1-yl)cyclopropyl]phenyl]-1,3,4-trimethyl-pyridin-2-one (3 entities in total) |
Functional Keywords | bromodomain, inhibitor, complex, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 14618.65 |
Authors | Bader, G.,Boettcher, J.,Wolkerstorfer, B. (deposition date: 2022-07-19, release date: 2022-08-31, Last modification date: 2024-02-07) |
Primary citation | Martinelli, P.,Schaaf, O.,Mantoulidis, A.,Martin, L.J.,Fuchs, J.E.,Bader, G.,Gollner, A.,Wolkerstorfer, B.,Rogers, C.,Balikci, E.,Lipp, J.J.,Mischerikow, N.,Doebel, S.,Gerstberger, T.,Sommergruber, W.,Huber, K.V.M.,Bottcher, J. Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. Chemmedchem, 18:e202200686-e202200686, 2023 Cited by PubMed: 36649575DOI: 10.1002/cmdc.202200686 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.025 Å) |
Structure validation
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