4YIH
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU
Summary for 4YIH
Entry DOI | 10.2210/pdb4yih/pdb |
Descriptor | 5'(3')-deoxyribonucleotidase, cytosolic type, MAGNESIUM ION, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | 5'-nucleotidase, dephosphorylation, phosphorylation, had-like, mitochondria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 46945.58 |
Authors | Pachl, P.,Rezacova, P.,Brynda, J. (deposition date: 2015-03-02, release date: 2015-09-09, Last modification date: 2024-01-10) |
Primary citation | Pachl, P.,Simak, O.,Rezacova, P.,Fabry, M.,Budesinsky, M.,Rosenberg, I.,Brynda, J. Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor Medchemcomm, 6:1635-1638, 2015 Cited by DOI: 10.1039/C5MD00235DPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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