4OYP

Human solAC Complexed with 1-Benzofuran-2-carboxylic acid

Summary for 4OYP

Related4OYA 4OYB 4OYI 4OYM 4OYO 4OYW 4OYX 4OYZ 4OZ2 4OZ3
DescriptorAdenylate cyclase type 10, CHLORIDE ION, 1-benzofuran-2-carboxylic acid, ... (4 entities in total)
Functional Keywordslyase
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Peripheral membrane protein; Cytoplasmic side Q96PN6
Total number of polymer chains1
Total molecular weight53664.43
Authors
Vinkovic, M. (deposition date: 2014-02-12, release date: 2014-04-02, Last modification date: 2014-10-01)
Primary citation
Saalau-Bethell, S.M.,Berdini, V.,Cleasby, A.,Congreve, M.,Coyle, J.E.,Lock, V.,Murray, C.W.,O'Brien, M.A.,Rich, S.J.,Sambrook, T.,Vinkovic, M.,Yon, J.R.,Jhoti, H.
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.
Chemmedchem, 9:823-832, 2014
PubMed: 24616449 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201300480
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.28 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23441.7%6.3%7.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4oyp
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Molmil generated image of 4oyp
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Molmil generated image of 4oyp
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More Biological unit images

Molmil generated image of 4oyp
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Molmil generated image of 4oyp
rotated about x axis by 90°
Molmil generated image of 4oyp
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4oyp.pdb1.gz [164.98 KB])
Coordinate files for Biological unit (4oyp.pdb2.gz [490.11 KB])