4OZ2

Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole

Summary for 4OZ2

Entry DOI	10.2210/pdb4oz2/pdb
Related	4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ3
Descriptor	Adenylate cyclase type 10, 4-(4-fluorophenyl)-3-methyl-1H-pyrazole, GLYCEROL, ... (5 entities in total)
Functional Keywords	protein-ligand complex, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side: Q96PN6
Total number of polymer chains	1
Total formula weight	53954.76
Authors	Vinkovic, M. (deposition date: 2014-02-13, release date: 2014-04-02, Last modification date: 2023-12-27)
Primary citation	Saalau-Bethell, S.M.,Berdini, V.,Cleasby, A.,Congreve, M.,Coyle, J.E.,Lock, V.,Murray, C.W.,O'Brien, M.A.,Rich, S.J.,Sambrook, T.,Vinkovic, M.,Yon, J.R.,Jhoti, H. Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9:823-832, 2014 Cited by PubMed: 24616449 DOI: 10.1002/cmdc.201300480 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation