PDB: 184249 件ウェブページステータス検索Chemie searchBIRD

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1Q9X	Crystal structure of Enterobacteria phage RB69 gp43 DNA polymerase complexed with tetrahydrofuran containing DNA 分子名称: 1',2'-DIDEOXYRIBOFURANOSE-5'-PHOSPHATE, 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ... 著者 Freisinger, E, Grollman, A.P, Miller, H, Kisker, C. 登録日 2003-08-26 公開日 2004-04-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Lesion (in)tolerance reveals insights into DNA replication fidelity. Embo J., 23, 2004
1LFG	Structure of diferric human lactoferrin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... 著者 Baker, E.N, Anderson, B.F, Haridas, M. 登録日 1992-02-05 公開日 1994-01-31 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of human diferric lactoferrin refined at 2.2 A resolution. Acta Crystallogr.,Sect.D, 51, 1995
4ZQC	Tryptophan Synthase from Salmonella typhimurium in complex with two molecules of N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and a single F6F molecule in the beta-site at 1.54 Angstrom resolution. 分子名称: 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, DIMETHYL SULFOXIDE, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Hilario, E, Caulkins, B.G, Young, R.P, Dunn, M.F, Mueller, L.J, Fan, L. 登録日 2015-05-08 公開日 2016-02-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water. Biochim.Biophys.Acta, 1864, 2016
6H65	Crystal structure of the branched-chain-amino-acid aminotransferase from Haliangium ochraceum 分子名称: Branched-chain-amino-acid aminotransferase, PYRIDOXAL-5'-PHOSPHATE 著者 Boyko, K.M, Timofeev, V.I, Bezsudnova, E.Y, Nikolaeva, A.Y, Rakitina, T.V, Popov, V.O. 登録日 2018-07-26 公開日 2018-10-10 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of the branched-chain-amino-acid aminotransferase from Haliangium ochraceum To Be Published
4Z7I	Crystal structure of insulin regulated aminopeptidase in complex with ligand 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DG025 transition-state analogue enzyme inhibitor, ... 著者 Mpakali, A, Saridakis, E, Harlos, K, Zhao, Y, Stratikos, E. 登録日 2015-04-07 公開日 2015-08-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. J Immunol., 195, 2015
4ZF6	Cytochrome P450 pentamutant from BM3 with bound PEG 分子名称: 1,2-ETHANEDIOL, Bifunctional P-450/NADPH-P450 reductase, NICKEL (II) ION, ... 著者 Rogers, W.E, Othman, T, Heidary, D.K, Huxford, T. 登録日 2015-04-21 公開日 2016-07-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.773 Å) 主引用文献 Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants. Biochemistry, 55, 2016
7JMT	Crystal structure of schistosome BCL-2 bound to ABT-737 分子名称: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, BCL-2 protein 著者 Smith, N.A, Smith, B.J, Lee, E.F, Colman, P.M, Fairlie, W.D. 登録日 2020-08-02 公開日 2021-02-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
1BOF	GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM 分子名称: GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Coleman, D.E, Sprang, S.R. 登録日 1998-08-04 公開日 1999-01-06 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment. Biochemistry, 37, 1998
7XTB	Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7XTC	Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex 分子名称: 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
6MZ0	Crystal structure of Tdp1 catalytic domain in complex with compound XZ530 分子名称: 1,2-ETHANEDIOL, 5-hydroxypyrazine-2,3-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 著者 Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. 登録日 2018-11-02 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.969 Å) 主引用文献 Structure of Tdp1 catalytic domain in complex with compound XZ530 To Be Published
7JW7	Structure of monobody 27 human MLKL pseudokinase domain complex 分子名称: Mixed lineage kinase domain-like protein, Monobody 27 著者 Meng, Y, Garnish, S.E, Koide, A, Koide, S, Czabotar, P.E, Murphy, J.M. 登録日 2020-08-25 公開日 2021-03-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis. Nat Commun, 12, 2021
7XT9	Serotonin 4 (5-HT4) receptor-Gs complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7XT8	Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
6N0R	Crystal structure of Tdp1 catalytic domain in complex with compound XZ572 分子名称: 1,2-ETHANEDIOL, 4-(methylamino)benzene-1,2-dicarboxylic acid, DIMETHYL SULFOXIDE, ... 著者 Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. 登録日 2018-11-07 公開日 2019-11-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.544 Å) 主引用文献 Crystal structure of Tdp1 catalytic domain To Be Published
6GXX	Fab fragment of an antibody selective for alpha-1-antitrypsin in the native conformation 分子名称: FAB 1D9 heavy chain, FAB 1D9 light chain, MAGNESIUM ION 著者 Elliston, E.L.K, Miranda, E, Perez, J, Lomas, D.A, Irving, J.A. 登録日 2018-06-27 公開日 2019-07-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Characterisation of a monoclonal antibody conformationally-selective for native alpha-1-antitrypsin To Be Published
5HPO	Cycloalternan-forming enzyme from Listeria monocytogenes in complex with maltopentaose 分子名称: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Halavaty, A.S, Light, S.H, Minasov, G, Winsor, J, Grimshaw, S, Shuvalova, L, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-01-20 公開日 2017-01-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. Structure, 25, 2017
2R0I	Crystal structure of a kinase MARK2/Par-1 mutant 分子名称: Serine/threonine-protein kinase MARK2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2007-08-20 公開日 2008-08-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Crystal structure of a kinase MARK2/Par-1 mutant To be Published
6GJU	human NBD1 of CFTR in complex with nanobodies T2a and T4 分子名称: Cystic fibrosis transmembrane conductance regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. 登録日 2018-05-17 公開日 2019-06-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
5DY9	Y68T Hfq from Methanococcus jannaschii in complex with AMP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... 著者 Nikulin, A.D, Mikhailina, A.O, Lekontseva, N.V, Balobanov, V.A, Nikonova, E.Y, Tishchenko, S.V. 登録日 2015-09-24 公開日 2016-09-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Characterization of RNA-binding properties of the archaeal Hfq-like protein from Methanococcus jannaschii. J. Biomol. Struct. Dyn., 35, 2017
1TBG	BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN 分子名称: TRANSDUCIN 著者 Sondek, J.S, Bohm, A, Lambright, D.G, Hamm, H.E, Sigler, P.B. 登録日 1996-06-15 公開日 1997-04-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature, 379, 1996
6N17	Crystal structure of Tdp1 catalytic domain in complex with compound XZ577 分子名称: 1,2-ETHANEDIOL, 4-[(3-carboxypropanoyl)amino]benzene-1,2-dicarboxylic acid, DIMETHYL SULFOXIDE, ... 著者 Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. 登録日 2018-11-08 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.639 Å) 主引用文献 Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
6NXL	Ubiquitin binding variants 分子名称: Polyubiquitin-B 著者 Miller, D.J, Watson, E.R. 登録日 2019-02-08 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.803 Å) 主引用文献 Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc.Natl.Acad.Sci.USA, 116, 2019
3I7C	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NA-PP2 分子名称: 1-tert-butyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) 登録日 2009-07-08 公開日 2010-02-09 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat.Struct.Mol.Biol., 17, 2010
1NES	STRUCTURE OF THE PRODUCT COMPLEX OF ACETYL-ALA-PRO-ALA WITH PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION 分子名称: ACETYL-ALA-PRO-ALA, CALCIUM ION, ELASTASE, ... 著者 Meyer Junior, E.F, Radhakrishnan, R, M Cole, G, Presta, L.G. 登録日 1995-07-31 公開日 1996-01-29 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution. J.Mol.Biol., 189, 1986

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