PDB: 7742 件ウェブページステータス検索Chemie searchBIRD

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5OI5	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OI3	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: Integrase, MAGNESIUM ION 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OIA	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ... 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OI2	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 分子名称: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-4-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION, ... 著者 Ruff, M, Benarous, R. 登録日 2017-07-18 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
2PSG	REFINED STRUCTURE OF PORCINE PEPSINOGEN AT 1.8 ANGSTROMS RESOLUTION 分子名称: PEPSINOGEN 著者 James, M.N.G, Sielecki, A.R. 登録日 1991-01-23 公開日 1992-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Refined structure of porcine pepsinogen at 1.8 A resolution. J.Mol.Biol., 219, 1991
1QJZ	Three Dimensional Structure of Physalis Mottle Virus : Implications for the Viral Assembly 分子名称: COAT PROTEIN 著者 Krishna, S.S, Hiremath, C.N, Munshi, S.K, Prahadeeswaran, D, Sastri, M, Savithri, H.S, Murthy, M.R.N. 登録日 1999-07-07 公開日 1999-07-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Three Dimensional Structure of Physalis Movirus: Implications for the Viral Assembly J.Mol.Biol., 289, 1999
8RND	Cathepsin S in complex with NNPI-C10 inhibitor 分子名称: 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ... 著者 Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. 登録日 2024-01-09 公開日 2024-06-05 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins. Nat.Chem.Biol., 2024
8SXM	NMR structure of the ZNF750 zinc finger domain, Z* 分子名称: ZINC ION, Zinc finger protein 750 著者 Rua, A.J, Alexandrescu, A.T. 登録日 2023-05-22 公開日 2023-08-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750. J Struct Biol X, 8, 2023
8TDO	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, variant-type morphology 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Saelices, L. 登録日 2023-07-04 公開日 2023-12-13 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8TDN	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Saelices, L. 登録日 2023-07-04 公開日 2023-12-13 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
5E5K	Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 4.3 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 protease 著者 Kovalevsky, A.Y, Das, A. 登録日 2015-10-08 公開日 2016-05-04 最終更新日 2024-03-06 実験手法 NEUTRON DIFFRACTION (1.75 Å), X-RAY DIFFRACTION 主引用文献 Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site. Angew.Chem.Int.Ed.Engl., 55, 2016
8Q8S	Tau - AD-THF 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. 登録日 2023-08-18 公開日 2023-09-20 最終更新日 2024-01-24 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8Z	Tau - CTE-MIA7 (tau intermediate amyloid) 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. 登録日 2023-08-19 公開日 2023-09-20 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9A	Tau - CTE-MIA11 (tau intermediate amyloid) 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. 登録日 2023-08-20 公開日 2023-09-20 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8E	Tau - AD-LIA4 (tau intermediate amyloid) 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. 登録日 2023-08-18 公開日 2023-09-20 最終更新日 2024-01-24 実験手法 ELECTRON MICROSCOPY (3.81 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8X	Tau - CTE-MIA5 (tau intermediate amyloid) 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. 登録日 2023-08-19 公開日 2023-09-20 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9B	Tau - CTE-MIA13 (tau intermediate amyloid) 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. 登録日 2023-08-20 公開日 2023-09-20 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8QJJ	CTE type II (tau intermediate amyloid) 分子名称: Isoform Tau-D of Microtubule-associated protein tau 著者 Lovestam, S, Scheres, S.H.W. 登録日 2023-09-13 公開日 2023-10-18 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
5FHL	Extensive amphimorphism in DNA: Three stable conformations for the decadeoxynucleotide d(GCATGCATGC) 分子名称: DNA (5'-D(*GP*CP*AP*TP*GP*CP*AP*TP*GP*C)-3') 著者 Thirugnanasambandam, A, Karthik, S, Gautham, N. 登録日 2015-12-22 公開日 2016-06-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.791 Å) 主引用文献 DNA polymorphism in crystals: three stable conformations for the decadeoxynucleotide d(GCATGCATGC). Acta Crystallogr D Struct Biol, 72, 2016
5HIB	EGFR kinase domain mutant "TMLR" with a pyrazolopyrimidine inhibitor 分子名称: Epidermal growth factor receptor, N-tert-butyl-5-{[(1-methyl-1H-pyrazol-5-yl)sulfonyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide 著者 Eigenbrot, C, Yu, C. 登録日 2016-01-11 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
5HIC	EGFR kinase domain mutant "TMLR" with a imidazopyridinyl-aminopyrimidine inhibitor 分子名称: Epidermal growth factor receptor, N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION 著者 Eigenbrot, C, Yu, C. 登録日 2016-01-11 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
5HCH	X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair 分子名称: (6S)-2,6-anhydro-1-deoxy-6-(2-{[(S)-hydroxy(oxido)-lambda~5~-phosphanyl]oxy}ethyl)-D-galactitol, CALCIUM ION, DNA (5'-D(*CP*GP*CP*AP*TP*TP*(DF)P*TP*AP*TP*CP*GP*C)-3'), ... 著者 Roethlisberger, P, Istrate, A, Marcaida Lopez, M.J, Visini, R, Stocker, A, Leumann, C.J. 登録日 2016-01-04 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chem.Commun.(Camb.), 52, 2016
5FHJ	Extensive amphimorphism in DNA: Three stable conformations for the decadeoxynucleotide d(GCATGCATGC) 分子名称: COBALT (II) ION, DNA (5'-D(*GP*CP*AP*TP*GP*CP*AP*TP*GP*C)-3') 著者 Thirugnanasambandam, A, Karthik, S, Gautham, N. 登録日 2015-12-22 公開日 2016-06-29 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 DNA polymorphism in crystals: three stable conformations for the decadeoxynucleotide d(GCATGCATGC). Acta Crystallogr D Struct Biol, 72, 2016
8AH7	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P212121 at pH 4.0 分子名称: SULFATE ION, cDNA FLJ50577, highly similar to Discs large homolog 4 著者 Camara-Artigas, A, Salinas-Garcia, M.C. 登録日 2022-07-20 公開日 2023-03-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
8E7E	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Afrin, S, Saelices, L. 登録日 2022-08-23 公開日 2023-08-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024

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