8W9W
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![BU of 8w9w by Molmil](/molmil-images/mine/8w9w) | The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine | 分子名称: | PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1, ~{N}-[(~{Z},2~{S},3~{R})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide | 著者 | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-02-28 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat.Struct.Mol.Biol., 31, 2024
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8UO8
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![BU of 8uo8 by Molmil](/molmil-images/mine/8uo8) | Structure of synaptic vesicle protein 2B with padsevonil | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[(4R)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], ... | 著者 | Martin, M.F, Mittal, A, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A. | 登録日 | 2023-10-19 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants. Nat.Struct.Mol.Biol., 2024
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8UTB
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![BU of 8utb by Molmil](/molmil-images/mine/8utb) | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Burke, S.M, Noviello, C.M, Hibbs, R.E. | 登録日 | 2023-10-30 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187, 2024
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8UT1
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![BU of 8ut1 by Molmil](/molmil-images/mine/8ut1) | Alpha7-nicotinic acetylcholine receptor bound to epibatidine | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Burke, S.M, Hibbs, R.E, Noviello, C.M. | 登録日 | 2023-10-30 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187, 2024
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8UZJ
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![BU of 8uzj by Molmil](/molmil-images/mine/8uzj) | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and ivermectin | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ... | 著者 | Burke, S.M, Noviello, C.M, Hibbs, R.E. | 登録日 | 2023-11-15 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187, 2024
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8XJO
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![BU of 8xjo by Molmil](/molmil-images/mine/8xjo) | U46619 bound Thromboxane A2 receptor-Gq Protein Complex | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
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8UKX
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8UE9
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![BU of 8ue9 by Molmil](/molmil-images/mine/8ue9) | Structure of TREK-1CG*:CAT335 | 分子名称: | CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... | 著者 | Mondal, A, Lee, H, Minor, D.L. | 登録日 | 2023-09-29 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of Trek-1(S131C mutant) with ML335 To Be Published
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8UKV
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8UKW
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9BHR
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![BU of 9bhr by Molmil](/molmil-images/mine/9bhr) | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-40155 compound | 分子名称: | (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-{(1E)-3-[(2-methoxyethyl)amino]-3-oxoprop-1-en-1-yl}-1H-pyrrole-3-carboxamide, DDB1- and CUL4-associated factor 1 | 著者 | kimani, S, Dong, A, Li, Y, Seitova, A, Al-Awar, R, Krausser, C, Wilson, B, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2024-04-21 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-40155 compound To be published
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7U1O
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![BU of 7u1o by Molmil](/molmil-images/mine/7u1o) | Crystal structure of queuine salvage enzyme DUF2419 complexed with queuosine | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-beta-D-ribofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, MALONATE ION, ... | 著者 | Hung, S.-H, Swairjo, M.A. | 登録日 | 2022-02-21 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate. Nucleic Acids Res., 51, 2023
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7U5A
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![BU of 7u5a by Molmil](/molmil-images/mine/7u5a) | Crystal structure of queuine salvage enzyme DUF2419 mutant K199C, complexed with queuosine | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-beta-D-ribofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, MALONATE ION, Queuine salvage enzyme DUF2419 | 著者 | Hung, S.-H, Swairjo, M.A. | 登録日 | 2022-03-01 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate. Nucleic Acids Res., 51, 2023
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7YIU
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![BU of 7yiu by Molmil](/molmil-images/mine/7yiu) | Cryo-EM structure of the C6-ceramide-bound SPT-ORMDL3 complex | 分子名称: | HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)HEXANAMIDE, ORM1-like protein 3, ... | 著者 | Xie, T, Liu, P, Gong, X. | 登録日 | 2022-07-18 | 公開日 | 2023-07-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 14, 2023
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7YIY
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![BU of 7yiy by Molmil](/molmil-images/mine/7yiy) | Cryo-EM structure of SPT-ORMDL3 complex | 分子名称: | N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Xie, T, Liu, P, Gong, X. | 登録日 | 2022-07-18 | 公開日 | 2023-07-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 14, 2023
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7YUB
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![BU of 7yub by Molmil](/molmil-images/mine/7yub) | S1P-bound human SPNS2 | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, NbFab-H-chain, NbFab-L-chain, ... | 著者 | He, Y, Duan, Y. | 登録日 | 2022-08-17 | 公開日 | 2023-09-06 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7VBZ
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![BU of 7vbz by Molmil](/molmil-images/mine/7vbz) | Matrix arm of active state CI from Rotenone-NADH dataset | 分子名称: | (2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... | 著者 | Gu, J.K, Yang, M.J. | 登録日 | 2021-09-01 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | The coupling mechanism of mammalian mitochondrial complex I. Nat.Struct.Mol.Biol., 29, 2022
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7YWU
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![BU of 7ywu by Molmil](/molmil-images/mine/7ywu) | Eugenol oxidase from rhodococcus jostii: mutant S81H, A423M, H434Y, S394V, I445D, S518P | 分子名称: | 2-methoxy-4-(prop-2-en-1-yl)phenol, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Alvigini, L, Mattevi, A. | 登録日 | 2022-02-14 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound. Nat Commun, 13, 2022
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7YWV
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![BU of 7ywv by Molmil](/molmil-images/mine/7ywv) | Eugenol oxidase from rhodococcus jostii: mutant S81H, D151E, A423M, H434Y, S394V, Q425S, I445D, S518P | 分子名称: | 2-methoxy-4-(prop-2-en-1-yl)phenol, CALCIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Alvigini, L, Mattevi, A. | 登録日 | 2022-02-14 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound. Nat Commun, 13, 2022
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7W3U
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![BU of 7w3u by Molmil](/molmil-images/mine/7w3u) | USP34 catalytic domain in complex with UbPA | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION, ... | 著者 | Xu, G.L, Ming, Z.H. | 登録日 | 2021-11-26 | 公開日 | 2022-06-01 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol., 434, 2022
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7YMK
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![BU of 7ymk by Molmil](/molmil-images/mine/7ymk) | Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with an Covalent Selective Estrogen Receptor Degrader 29c and GRIP Peptide | 分子名称: | DI(HYDROXYETHYL)ETHER, Estrogen receptor, Grip peptide, ... | 著者 | Min, J, Hu, H.B, Yang, Y, Dong, C.E, Zhou, H.B, Chen, C.-C, Guo, R.-T. | 登録日 | 2022-07-28 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer. Acta Pharm Sin B, 13, 2023
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7V33
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![BU of 7v33 by Molmil](/molmil-images/mine/7v33) | Active state complex I from rotenone-NADH dataset | 分子名称: | (2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... | 著者 | Gu, J.K, Yang, M.J. | 登録日 | 2021-08-10 | 公開日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | The coupling mechanism of mammalian mitochondrial complex I. Nat.Struct.Mol.Biol., 29, 2022
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7V31
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![BU of 7v31 by Molmil](/molmil-images/mine/7v31) | Active state complex I from rotenone dataset | 分子名称: | (2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrofuro[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-6(6aH)-one, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... | 著者 | Gu, J.K, Yang, M.J. | 登録日 | 2021-08-10 | 公開日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The coupling mechanism of mammalian mitochondrial complex I. Nat.Struct.Mol.Biol., 29, 2022
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7UHF
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![BU of 7uhf by Molmil](/molmil-images/mine/7uhf) | Human L-type voltage-gated calcium channel Cav1.3 in the presence of cinnarizine at 3.1 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-03-26 | 公開日 | 2022-05-11 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
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7UW2
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![BU of 7uw2 by Molmil](/molmil-images/mine/7uw2) | Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with UAB116 and coactivator peptide GRIP-1 | 分子名称: | (2E,4E,6Z,8E)-8-{3-[(2S)-butan-2-yl]-2-(3-methylbutyl)cyclohex-2-en-1-ylidene}-3,7-dimethylocta-2,4,6-trienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | 著者 | Chattopadhyay, D, Yang, Z, Atigadda, V. | 登録日 | 2022-05-02 | 公開日 | 2023-03-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers. J.Med.Chem., 65, 2022
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