7UW2

Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with UAB116 and coactivator peptide GRIP-1

Summary for 7UW2

• Entry DOI: 10.2210/pdb7uw2/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-8-{3-[(2S)-butan-2-yl]-2-(3-methylbutyl)cyclohex-2-en-1-ylidene}-3,7-dimethylocta-2,4,6-trienoic acid, ... (4 entities in total)
• Functional Keywords: retinoid x receptor, retinoid x receptor alpha, ligand binding domain, coactivator complex, inhibitor complex, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28806.47

Authors

Chattopadhyay, D.,Yang, Z.,Atigadda, V. (deposition date: 2022-05-02, release date: 2023-03-15, Last modification date: 2023-10-25)

• Primary citation: Atigadda, V.R.,Kashyap, M.P.,Yang, Z.,Chattopadhyay, D.,Melo, N.,Sinha, R.,Belyaeva, O.V.,Chou, C.F.,Chang, P.L.,Kedishvili, N.Y.,Grubbs, C.J.,Renfrow, M.B.,Muccio, D.D.,Elmets, C.A.,Athar, M.; Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers.; J.Med.Chem., 65:14409-14423, 2022; PubMed: 36318154; DOI: 10.1021/acs.jmedchem.2c00735

Experimental method

X-RAY DIFFRACTION (1.88 Å)