4Z1S
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![BU of 4z1s by Molmil](/molmil-images/mine/4z1s) | Crystal structure of the first bromodomain of human BRD4 with benzotriazolo-diazepine scaffold | 分子名称: | 5-[(4S)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-8-yl]pyridin-2-amine, Bromodomain-containing protein 4 | 著者 | Setser, J.W, Poy, F, Tang, Y, Bellon, S.F. | 登録日 | 2015-03-27 | 公開日 | 2015-04-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains. Acs Med.Chem.Lett., 7, 2016
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4OX3
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![BU of 4ox3 by Molmil](/molmil-images/mine/4ox3) | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition | 分子名称: | PHOSPHATE ION, Putative carboxypeptidase YodJ, ZINC ION | 著者 | Hoyland, C.N, Aldridge, C, Cleverley, R.M, Sidiq, K, Duchene, M.C, Daniel, R.A, Vollmer, W, Lewis, R.J. | 登録日 | 2014-02-04 | 公開日 | 2014-06-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure, 22, 2014
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4OBC
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![BU of 4obc by Molmil](/molmil-images/mine/4obc) | Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238) | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Edwards, T.E, Abendroth, J, Appleby, T.C. | 登録日 | 2014-01-07 | 公開日 | 2014-09-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance. Antimicrob.Agents Chemother., 58, 2014
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4Z4P
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![BU of 4z4p by Molmil](/molmil-images/mine/4z4p) | Structure of the MLL4 SET Domain | 分子名称: | Histone-lysine N-methyltransferase 2D, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Zhang, Z, Mittal, A, Reid, J, Reich, S, Gamblin, S.J, Wilson, J.R. | 登録日 | 2015-04-02 | 公開日 | 2015-09-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Evolving Catalytic Properties of the MLL Family SET Domain. Structure, 23, 2015
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4P6P
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![BU of 4p6p by Molmil](/molmil-images/mine/4p6p) | Structure of ribB complexed with inhibitor (4PEH) and metal ions | 分子名称: | 3,4-dihydroxy-2-butanone 4-phosphate synthase, 4-PHOSPHO-D-ERYTHRONOHYDROXAMIC ACID, ZINC ION | 著者 | Islam, Z, Kumar, A, Singh, S, Salmon, L, Karthikeyan, S. | 登録日 | 2014-03-25 | 公開日 | 2015-03-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.862 Å) | 主引用文献 | Structural Basis for Competitive Inhibition of 3,4-Dihydroxy-2-butanone-4-phosphate Synthase from Vibrio cholerae. J.Biol.Chem., 290, 2015
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4Z5R
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![BU of 4z5r by Molmil](/molmil-images/mine/4z5r) | Rontalizumab Fab bound to Interferon-a2 | 分子名称: | Interferon alpha-2, SULFATE ION, anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab), ... | 著者 | Eigenbrot, C, Maurer, B, Bosanac, I. | 登録日 | 2015-04-02 | 公開日 | 2015-07-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis of the broadly neutralizing anti-interferon-alpha antibody rontalizumab. Protein Sci., 24, 2015
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4Z47
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![BU of 4z47 by Molmil](/molmil-images/mine/4z47) | Structure of the enzyme-product complex resulting from TDG action on a GU mismatch in the presence of excess base | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, DNA, ... | 著者 | Pozharski, E, Malik, S.S, Drohat, A.C. | 登録日 | 2015-04-01 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
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4OCD
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![BU of 4ocd by Molmil](/molmil-images/mine/4ocd) | In and Out the minor groove: Interaction of an AT rich-DNA with the CD27 drug | 分子名称: | N1-(4,5-dihydro-1H-imidazol-2-yl)-N4-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzene-1,4-diamine, d(AAAATTTT) | 著者 | Acosta-Reyes, F.J, Dardonville, C, de Koning, H.P, Natto, M, Subirana, J.A, Campos, J.L. | 登録日 | 2014-01-08 | 公開日 | 2014-06-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27 Acta Crystallogr.,Sect.D, D70, 2014
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4OCG
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4O9V
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![BU of 4o9v by Molmil](/molmil-images/mine/4o9v) | Crystal structure of matriptase in complex with inhibitor | 分子名称: | N-(trans-4-aminocyclohexyl)-3,5-bis(4-carbamimidoylphenoxy)benzamide, Peptide CGLR, Suppressor of tumorigenicity 14 protein | 著者 | Rao, K.N, Chandra, B.R, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S, Subramanya, H.S. | 登録日 | 2014-01-03 | 公開日 | 2014-05-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy. Bioorg.Med.Chem., 22, 2014
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4OA5
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4ODT
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4Z9W
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![BU of 4z9w by Molmil](/molmil-images/mine/4z9w) | Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd)-Native-2 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chandran, T, Sharma, A, Vijayan, M. | 登録日 | 2015-04-12 | 公開日 | 2016-03-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Structural studies on a non-toxic homologue of type II RIPs from bitter gourd: Molecular basis of non-toxicity, conformational selection and glycan structure. J.Biosci., 40, 2015
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4ZA5
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![BU of 4za5 by Molmil](/molmil-images/mine/4za5) | Structure of A. niger Fdc1 with the prenylated-flavin cofactor in the iminium and ketimine forms. | 分子名称: | 1-deoxy-5-O-phosphono-1-(3,3,4,5-tetramethyl-9,11-dioxo-2,3,8,9,10,11-hexahydro-7H-quinolino[1,8-fg]pteridin-12-ium-7-y l)-D-ribitol, 1-deoxy-5-O-phosphono-1-[(10aR)-2,2,3,4-tetramethyl-8,10-dioxo-1,2,8,9,10,10a-hexahydro-6H-indeno[1,7-ef]pyrimido[4,5-b][1,4]diazepin-6-yl]-D-ribitol, Fdc1, ... | 著者 | Payne, K.A.P, Leys, D. | 登録日 | 2015-04-13 | 公開日 | 2015-06-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | New cofactor supports alpha , beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. Nature, 522, 2015
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4OEK
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![BU of 4oek by Molmil](/molmil-images/mine/4oek) | Crystal Structure of the Complex of goat Lactoperoxidase with Phenylethylamine at 2.47 A Resolution | 分子名称: | 1,2-ETHANEDIOL, 2-PHENYLETHYLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kumar, M, Singh, R.P, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. | 登録日 | 2014-01-13 | 公開日 | 2014-01-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Crystal Structure of the Complex of goat Lactoperoxidase with Phenylethylamine at 2.47 A To be Published
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4OC3
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![BU of 4oc3 by Molmil](/molmil-images/mine/4oc3) | X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CFIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxy-2-(furan-2-yl)ethyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. | 登録日 | 2014-01-08 | 公開日 | 2014-05-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
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4ZCB
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![BU of 4zcb by Molmil](/molmil-images/mine/4zcb) | Human CRBPII mutant - Y60W dimer | 分子名称: | Retinol-binding protein 2 | 著者 | Nossoni, Z, Assar, Z, Wang, W, Geiger, J, Borhan, B. | 登録日 | 2015-04-15 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates. Structure, 24, 2016
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4OCK
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![BU of 4ock by Molmil](/molmil-images/mine/4ock) | N-acetylhexosamine 1-phosphate kinase in complex with GlcNAc and AMPPNP | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, N-acetylhexosamine 1-phosphate kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Li, T.L, Wang, K.C, Lyu, S.Y, Liu, Y.C, Chang, C.Y, Wu, C.J. | 登録日 | 2014-01-09 | 公開日 | 2014-05-14 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes. Acta Crystallogr.,Sect.D, 70, 2014
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4YXT
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4OEZ
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![BU of 4oez by Molmil](/molmil-images/mine/4oez) | Crystal structure of AR-LBD bound with co-regulator peptide | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION, ... | 著者 | Liu, J.S, Hsu, C.L, Wu, W.G. | 登録日 | 2014-01-14 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
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4OCT
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![BU of 4oct by Molmil](/molmil-images/mine/4oct) | Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate | 分子名称: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, RNA demethylase ALKBH5, ... | 著者 | Tempel, W, Chao, X, Liu, K, Dong, A, Cerovina, T, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2014-01-09 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289, 2014
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4YYK
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![BU of 4yyk by Molmil](/molmil-images/mine/4yyk) | Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide | 分子名称: | Bromodomain-containing protein 9, Histone H4 | 著者 | Tang, Y, Bellon, S, Cochran, A.G, Poy, F. | 登録日 | 2015-03-24 | 公開日 | 2015-09-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications. Structure, 23, 2015
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4ZAF
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4ZAM
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4ZAY
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![BU of 4zay by Molmil](/molmil-images/mine/4zay) | Structure of UbiX E49Q in complex with a covalent adduct between dimethylallyl monophosphate and reduced FMN | 分子名称: | 1-deoxy-1-[7,8-dimethyl-5-(3-methylbut-2-en-1-yl)-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono -D-ribitol, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | White, M.D, Leys, D. | 登録日 | 2015-04-14 | 公開日 | 2015-06-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis. Nature, 522, 2015
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