4EDV
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![BU of 4edv by Molmil](/molmil-images/mine/4edv) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to pppGpp and Manganese | 分子名称: | BENZAMIDINE, DNA primase, MANGANESE (II) ION, ... | 著者 | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | 登録日 | 2012-03-27 | 公開日 | 2012-07-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EDK
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![BU of 4edk by Molmil](/molmil-images/mine/4edk) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to GTP and Manganese | 分子名称: | BENZAMIDINE, DNA primase, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | 登録日 | 2012-03-27 | 公開日 | 2012-07-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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6HVO
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![BU of 6hvo by Molmil](/molmil-images/mine/6hvo) | Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta | 分子名称: | DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION | 著者 | Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A. | 登録日 | 2018-10-11 | 公開日 | 2019-01-23 | 最終更新日 | 2019-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). J.Biol.Chem., 294, 2019
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4EDG
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![BU of 4edg by Molmil](/molmil-images/mine/4edg) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to ATP and Manganese | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, BENZAMIDINE, DNA primase, ... | 著者 | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | 登録日 | 2012-03-27 | 公開日 | 2012-07-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EE1
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![BU of 4ee1 by Molmil](/molmil-images/mine/4ee1) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to CTP and Manganese | 分子名称: | BENZAMIDINE, CYTIDINE-5'-TRIPHOSPHATE, DNA primase, ... | 著者 | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | 登録日 | 2012-03-28 | 公開日 | 2012-07-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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7QHL
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![BU of 7qhl by Molmil](/molmil-images/mine/7qhl) | Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24 | 分子名称: | 1,2-ETHANEDIOL, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, Cyclin-A2, ... | 著者 | Djukic, S, Skerlova, J, Rezacova, P. | 登録日 | 2021-12-13 | 公開日 | 2022-07-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J.Med.Chem., 65, 2022
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3AX1
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3MMY
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![BU of 3mmy by Molmil](/molmil-images/mine/3mmy) | |
3S24
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![BU of 3s24 by Molmil](/molmil-images/mine/3s24) | Crystal structure of human mRNA guanylyltransferase | 分子名称: | SULFATE ION, mRNA-capping enzyme | 著者 | Das, K, Chu, C, Thyminski, J.R, Bauman, J.D, Guan, R, Qiu, W, Montelione, G.T, Arnold, E, Shatkin, A.J. | 登録日 | 2011-05-16 | 公開日 | 2011-06-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.0137 Å) | 主引用文献 | Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proc.Natl.Acad.Sci.USA, 108, 2011
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1ENW
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![BU of 1enw by Molmil](/molmil-images/mine/1enw) | |
1XJR
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![BU of 1xjr by Molmil](/molmil-images/mine/1xjr) | The Structure of a Rigorously Conserved RNA Element Within the SARS Virus Genome | 分子名称: | MAGNESIUM ION, s2m RNA | 著者 | Robertson, M.P, Igel, H, Baertsch, R, Haussler, D, Ares Jr, M, Scott, W.G. | 登録日 | 2004-09-24 | 公開日 | 2005-02-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structure of a rigorously conserved RNA element within the SARS virus genome Plos Biol., 3, 2005
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3HYF
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![BU of 3hyf by Molmil](/molmil-images/mine/3hyf) | Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor | 分子名称: | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ... | 著者 | Lansdon, E.B, Kirschberg, T.A. | 登録日 | 2009-06-22 | 公開日 | 2009-10-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J.Med.Chem., 52, 2009
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7E15
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5BKH
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5FLX
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![BU of 5flx by Molmil](/molmil-images/mine/5flx) | Mammalian 40S HCV-IRES complex | 分子名称: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | 著者 | Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. | 登録日 | 2015-10-28 | 公開日 | 2015-12-23 | 最終更新日 | 2017-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA. Embo J., 34, 2015
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7OM6
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7Q2J
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![BU of 7q2j by Molmil](/molmil-images/mine/7q2j) | Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer | 分子名称: | Elongin-B, Elongin-C, N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide, ... | 著者 | Kraemer, A, Doelle, A, Schwalm, M.P, Adhikari, B, Wolf, E, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-10-25 | 公開日 | 2021-11-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. Cell Chem Biol, 30, 2023
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7KI3
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8G6R
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![BU of 8g6r by Molmil](/molmil-images/mine/8g6r) | Porcine epidemic diarrhea virus core polymerase complex | 分子名称: | RNA (5'-R(P*AP*AP*GP*AP*AP*GP*CP*UP*AP*UP*UP*AP*AP*AP*AP*UP*CP*AP*CP*A)-3'), RNA (5'-R(P*GP*GP*UP*UP*GP*UP*GP*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*U)-3'), ZINC ION, ... | 著者 | Anderson, T.K, Kirchdoerfer, R.N. | 登録日 | 2023-02-15 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | An alphacoronavirus polymerase structure reveals conserved co-factor functions. Biorxiv, 2023
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6N4O
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8URB
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3W1K
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4GHA
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![BU of 4gha by Molmil](/molmil-images/mine/4gha) | Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA | 分子名称: | Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3') | 著者 | Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O. | 登録日 | 2012-08-07 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism. Plos Pathog., 8, 2012
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3ISD
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![BU of 3isd by Molmil](/molmil-images/mine/3isd) | Ternary complex of human DNA polymerase beta with an abasic site (THF): DAPCPP mismatch | 分子名称: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, 5'-D(*CP*CP*GP*AP*CP*(3DR)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', ... | 著者 | Beard, W.A, Shock, D.D, Batra, V.K, Pedersen, L.C, Wilson, S.H. | 登録日 | 2009-08-25 | 公開日 | 2009-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". J.Biol.Chem., 284, 2009
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5ZYQ
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![BU of 5zyq by Molmil](/molmil-images/mine/5zyq) | The Structure of Human PAF1/CTR9 complex | 分子名称: | RNA polymerase-associated protein CTR9 homolog,RNA polymerase II-associated factor 1 homolog | 著者 | Xie, Y, Zheng, M, Zhou, H, Long, J. | 登録日 | 2018-05-28 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.531 Å) | 主引用文献 | Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation. Nat Commun, 9, 2018
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