5TWN
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![BU of 5twn by Molmil](/molmil-images/mine/5twn) | CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, NS5B RNA- DEPENDENT RNA POLYMERASE, ... | 著者 | Sheriff, S. | 登録日 | 2016-11-14 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. Medchemcomm, 8, 2017
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6U5O
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![BU of 6u5o by Molmil](/molmil-images/mine/6u5o) | Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer | 分子名称: | Phosphoprotein, RNA-directed RNA polymerase L | 著者 | Pan, J, Qian, X, Lattmann, S, Sahili, A.E, Yeo, T.H, Kalocsay, M, Fearns, R, Lescar, J. | 登録日 | 2019-08-28 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature, 577, 2020
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4E7A
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![BU of 4e7a by Molmil](/molmil-images/mine/4e7a) | |
6EOJ
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![BU of 6eoj by Molmil](/molmil-images/mine/6eoj) | PolyA polymerase module of the cleavage and polyadenylation factor (CPF) from Saccharomyces cerevisiae | 分子名称: | Polyadenylation factor subunit 2,Polyadenylation factor subunit 2, Protein CFT1, ZINC ION, ... | 著者 | Casanal, A, Kumar, A, Hill, C.H, Emsley, P, Passmore, L.A. | 登録日 | 2017-10-09 | 公開日 | 2017-11-15 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Architecture of eukaryotic mRNA 3'-end processing machinery. Science, 358, 2017
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4HDH
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![BU of 4hdh by Molmil](/molmil-images/mine/4hdh) | Crystal Structure of viral RdRp in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2012-10-02 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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4E78
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![BU of 4e78 by Molmil](/molmil-images/mine/4e78) | |
6IRZ
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![BU of 6irz by Molmil](/molmil-images/mine/6irz) | Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA | 分子名称: | 1,2-ETHANEDIOL, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, PDX1 C-terminal-inhibiting factor 1, ... | 著者 | Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2018-11-15 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363, 2019
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4HDG
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![BU of 4hdg by Molmil](/molmil-images/mine/4hdg) | Crystal Structure of viral RdRp in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Polyprotein, ZINC ION | 著者 | Surana, P, Nair, D.T. | 登録日 | 2012-10-02 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res., 42, 2014
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7VGQ
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![BU of 7vgq by Molmil](/molmil-images/mine/7vgq) | Cryo-EM structure of Machupo virus polymerase L in complex with matrix protein Z | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,RING finger protein Z, RNA-directed RNA polymerase L, ZINC ION | 著者 | Zhang, X, Ma, J, Zhang, S. | 登録日 | 2021-09-18 | 公開日 | 2021-09-29 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of Machupo virus polymerase in complex with matrix protein Z. Nat Commun, 12, 2021
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7RKP
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![BU of 7rkp by Molmil](/molmil-images/mine/7rkp) | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 | 分子名称: | (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | 著者 | Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. | 登録日 | 2021-07-22 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
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3H5Y
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![BU of 3h5y by Molmil](/molmil-images/mine/3h5y) | Norovirus polymerase+primer/template+CTP complex at 6 mM MnCl2 | 分子名称: | 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', CYTIDINE-5'-TRIPHOSPHATE, ... | 著者 | Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. | 登録日 | 2009-04-22 | 公開日 | 2009-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J.Mol.Biol., 390, 2009
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8R8R
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![BU of 8r8r by Molmil](/molmil-images/mine/8r8r) | Cryo-EM structure of the human mPSF with PAPOA C-terminus peptide (PAPOAc) | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*A)-3'), ... | 著者 | Todesca, S, Sandmeir, F, Keidel, A, Conti, E. | 登録日 | 2023-11-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Molecular basis of human poly(A) polymerase recruitment by mPSF. Rna, 30, 2024
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4NLD
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![BU of 4nld by Molmil](/molmil-images/mine/4nld) | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with BMS-791325 also known as (1aR,12bS)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide | 分子名称: | (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, ... | 著者 | Sheriff, S. | 登録日 | 2013-11-14 | 公開日 | 2014-03-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase. J.Med.Chem., 57, 2014
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3BSN
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4OBC
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![BU of 4obc by Molmil](/molmil-images/mine/4obc) | Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238) | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Edwards, T.E, Abendroth, J, Appleby, T.C. | 登録日 | 2014-01-07 | 公開日 | 2014-09-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance. Antimicrob.Agents Chemother., 58, 2014
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3BSO
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![BU of 3bso by Molmil](/molmil-images/mine/3bso) | |
7DTE
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![BU of 7dte by Molmil](/molmil-images/mine/7dte) | SARS-CoV-2 RdRP catalytic complex with T33-1 RNA | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (33-MER), ... | 著者 | Wang, Q, Gong, P. | 登録日 | 2021-01-04 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. Cell Rep, 37, 2021
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2XXD
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![BU of 2xxd by Molmil](/molmil-images/mine/2xxd) | HCV-JFH1 NS5B polymerase structure at 1.9 angstrom | 分子名称: | PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Caillet-Saguy, C, Bressanelli, S. | 登録日 | 2010-11-10 | 公開日 | 2011-01-12 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.881 Å) | 主引用文献 | A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes. J.Virol., 85, 2011
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7EJU
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![BU of 7eju by Molmil](/molmil-images/mine/7eju) | |
2WK4
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![BU of 2wk4 by Molmil](/molmil-images/mine/2wk4) | Dimeric structure of D347G D348G mutant of the sapporovirus RNA dependent RNA polymerase | 分子名称: | GLYCEROL, PROTEASE-POLYMERASE P70 | 著者 | Fullerton, S.W.B, Robel, I, Schuldt, L, Gebhardt, J, Tucker, P.A, Rohayem, J. | 登録日 | 2009-06-05 | 公開日 | 2010-09-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Dimeric Structure of D347G D348G Mutant of the Sapporovirus Sapporovirus RNA Dependent RNA Polymerase To be Published
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3GYN
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![BU of 3gyn by Molmil](/molmil-images/mine/3gyn) | Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor | 分子名称: | N-{3-[(5R)-1-cyclopentyl-4-hydroxy-5-methyl-5-(3-methylbutyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | 登録日 | 2009-04-04 | 公開日 | 2009-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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3IGV
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![BU of 3igv by Molmil](/molmil-images/mine/3igv) | Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydro-pyridinone inhibitor | 分子名称: | N-{3-[(6S)-6-ethyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | 登録日 | 2009-07-28 | 公開日 | 2009-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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4PZ8
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![BU of 4pz8 by Molmil](/molmil-images/mine/4pz8) | PCE1 guanylyltransferase bound to SPT5 CTD | 分子名称: | SULFATE ION, Transcription elongation factor spt5, mRNA-capping enzyme subunit alpha | 著者 | Doamekpor, S.K, Lima, C.D. | 登録日 | 2014-03-28 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev., 28, 2014
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5JXS
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4PZ7
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![BU of 4pz7 by Molmil](/molmil-images/mine/4pz7) | PCE1 guanylyltransferase | 分子名称: | GLYCEROL, SULFATE ION, mRNA-capping enzyme subunit alpha | 著者 | Doamekpor, S.K, Lima, C.D. | 登録日 | 2014-03-28 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | 主引用文献 | How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev., 28, 2014
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