3HK9
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![BU of 3hk9 by Molmil](/molmil-images/mine/3hk9) | Crystal structure of uronate isomerase from Bacillus halodurans complexed with zinc and D-Glucuronate | 分子名称: | CARBONATE ION, CHLORIDE ION, D-glucuronic acid, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Nguyen, T.T, Raushel, F.M, Almo, S.C. | 登録日 | 2009-05-22 | 公開日 | 2009-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily. Biochemistry, 48, 2009
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3HK7
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![BU of 3hk7 by Molmil](/molmil-images/mine/3hk7) | Crystal structure of uronate isomerase from Bacillus halodurans complexed with zinc and D-Arabinarate, monoclinic crystal form | 分子名称: | CARBONATE ION, CHLORIDE ION, D-arabinaric acid, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Nguyen, T.T, Raushel, F.M, Almo, S.C. | 登録日 | 2009-05-22 | 公開日 | 2009-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily. Biochemistry, 48, 2009
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6Z8X
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![BU of 6z8x by Molmil](/molmil-images/mine/6z8x) | X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3Leu), which contains leucyl amide in the side chain of Thy3 at N3. | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | 著者 | Troisi, R, Timofeev, E.N, Sica, F. | 登録日 | 2020-06-02 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23, 2021
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2R8X
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![BU of 2r8x by Molmil](/molmil-images/mine/2r8x) | Crystal structure of YrbI phosphatase from Escherichia coli | 分子名称: | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, CHLORIDE ION | 著者 | Tsodikov, O.V, Aggarwal, P, Rubin, J.R, Stuckey, J.A, Woodard, R.W, Biswas, T. | 登録日 | 2007-09-11 | 公開日 | 2008-09-23 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The Tail of KdsC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE. J.Biol.Chem., 284, 2009
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8RXR
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![BU of 8rxr by Molmil](/molmil-images/mine/8rxr) | Crystal structure of VPS34 in complex with inhibitor SB02024 | 分子名称: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | 登録日 | 2024-02-07 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol, 2024
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6Z8V
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![BU of 6z8v by Molmil](/molmil-images/mine/6z8v) | X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3L), which contains 1-beta-D-lactopyranosyl residue in the side chain of Thy3 at N3. | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | 著者 | Troisi, R, Timofeev, E.N, Sica, F. | 登録日 | 2020-06-02 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23, 2021
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4K9J
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![BU of 4k9j by Molmil](/molmil-images/mine/4k9j) | Structure of Re(CO)3(4,7-dimethyl-phen)(Thr126His)(Lys122Trp)(His83Glu)(Trp48Phe)(Tyr72Phe)(Tyr108Phe)AzCu(II), a Rhenium modified Azurin mutant | 分子名称: | (1,10 PHENANTHROLINE)-(TRI-CARBON MONOXIDE) RHENIUM (I), Azurin, COPPER (II) ION | 著者 | Takematsu, K, Williamson, H.R, Blanco-Rodriguez, A.M, Sokolova, L, Nikolovski, P, Kaiser, J.T, Towrie, M, Clark, I.P, Vlcek Jr, A, Winkler, J.R, Gray, H.B. | 登録日 | 2013-04-20 | 公開日 | 2013-10-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Tryptophan-accelerated electron flow across a protein-protein interface. J.Am.Chem.Soc., 135, 2013
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2GAX
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![BU of 2gax by Molmil](/molmil-images/mine/2gax) | Structure of Protein of Unknown Function Atu0240 from Agrobacteriium tumerfaciencs str. C58 | 分子名称: | PHOSPHATE ION, hypothetical protein Atu0240 | 著者 | Binkowski, T.A, Evdokimova, E, Kudritska, M, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-03-09 | 公開日 | 2006-05-09 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Hypothetical protein Atu0240 from Agrobacteriium tumerfaciencs str. C58 TO BE PUBLISHED
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7LHQ
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![BU of 7lhq by Molmil](/molmil-images/mine/7lhq) | Solution structure of SARS-CoV-2 nonstructural protein 7 at pH 7.0 | 分子名称: | Non-structural protein 7 | 著者 | Lee, Y, Tonelli, M, Anderson, T.K, Kirchdoerfer, R.N, Henzler-Wildman, K, Lee, W. | 登録日 | 2021-01-26 | 公開日 | 2022-02-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | pH-dependent polymorphism of the structure of SARS-CoV-2 nsp7 Biorxiv, 2021
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2GBT
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![BU of 2gbt by Molmil](/molmil-images/mine/2gbt) | C6A/C111A CuZn Superoxide dismutase | 分子名称: | COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION | 著者 | Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M. | 登録日 | 2006-03-11 | 公開日 | 2007-01-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase J.Mol.Biol., 365, 2007
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2GBU
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![BU of 2gbu by Molmil](/molmil-images/mine/2gbu) | C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Hornberg, A, Logan, D.T, Marklund, S.L, Oliveberg, M. | 登録日 | 2006-03-11 | 公開日 | 2007-01-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Coupling between Disulphide Status, Metallation and Dimer Interface Strength in Cu/Zn Superoxide Dismutase J.Mol.Biol., 365, 2007
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4UPH
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![BU of 4uph by Molmil](/molmil-images/mine/4uph) | Crystal Structure of Phosphonate Monoester Hydrolase of Agrobacterium radiobacter | 分子名称: | CHLORIDE ION, MAGNESIUM ION, SULFATASE (SULFURIC ESTER HYDROLASE) PROTEIN | 著者 | Fischer, G, Loo, B.v, Hyvonen, M, Hollfelder, F. | 登録日 | 2014-06-17 | 公開日 | 2015-07-01 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily. J.Am.Chem.Soc., 141, 2019
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5LG2
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![BU of 5lg2 by Molmil](/molmil-images/mine/5lg2) | Horse L type ferritin iron loaded for 60 minutes | 分子名称: | CADMIUM ION, CHLORIDE ION, FE (III) ION, ... | 著者 | Pozzi, C, Di Pisa, F, Mangani, S. | 登録日 | 2016-07-05 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional ( mu (3)-oxo)Tris[( mu (2)-peroxo)] triiron(III) cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2G9B
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![BU of 2g9b by Molmil](/molmil-images/mine/2g9b) | NMR solution structure of CA2+-loaded calbindin D28K | 分子名称: | Calbindin | 著者 | Kojetin, D.J, Venters, R.A, Kordys, D.R, Thompson, R.J, Kumar, R, Cavanagh, J. | 登録日 | 2006-03-06 | 公開日 | 2006-07-04 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure, binding interface and hydrophobic transitions of Ca(2+)-loaded calbindin-D(28K). Nat.Struct.Mol.Biol., 13, 2006
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4HAF
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![BU of 4haf by Molmil](/molmil-images/mine/4haf) | Crystal structure of fc-fragment of human IgG2 antibody (primitive crystal form) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-2 chain C region | 著者 | Teplyakov, A, Malia, T, Obmolova, G, Zhao, Y, Gilliland, G. | 登録日 | 2012-09-26 | 公開日 | 2013-06-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface. Mol.Immunol., 56, 2013
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1IRB
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![BU of 1irb by Molmil](/molmil-images/mine/1irb) | CARBOXYLIC ESTER HYDROLASE | 分子名称: | CALCIUM ION, PHOSPHOLIPASE A2 | 著者 | Sundaralingam, M. | 登録日 | 1997-08-13 | 公開日 | 1997-12-24 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface. Biochemistry, 35, 1996
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1S0W
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![BU of 1s0w by Molmil](/molmil-images/mine/1s0w) | |
8TW3
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![BU of 8tw3 by Molmil](/molmil-images/mine/8tw3) | |
1BO1
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![BU of 1bo1 by Molmil](/molmil-images/mine/1bo1) | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA | 分子名称: | PROTEIN (PHOSPHATIDYLINOSITOL PHOSPHATE KINASE IIBETA) | 著者 | Rao, V.D, Misra, S, Boronenkov, I.V, Anderson, R.A, Hurley, J.H. | 登録日 | 1998-08-02 | 公開日 | 1998-10-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell(Cambridge,Mass.), 94, 1998
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8TTM
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![BU of 8ttm by Molmil](/molmil-images/mine/8ttm) | IgG1 Fc Heterodimer combYSelect1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain | 著者 | Azzam, T, Du, J.J, Sundberg, E.J. | 登録日 | 2023-08-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers. Sci Adv, 10, 2024
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5LG8
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![BU of 5lg8 by Molmil](/molmil-images/mine/5lg8) | Human L-type ferritin iron loaded for 60 minutes | 分子名称: | CADMIUM ION, FE (III) ION, Ferritin light chain, ... | 著者 | Pozzi, C, Di Pisa, F, Mangani, S. | 登録日 | 2016-07-06 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional ( mu (3)-oxo)Tris[( mu (2)-peroxo)] triiron(III) cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8TUD
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![BU of 8tud by Molmil](/molmil-images/mine/8tud) | IgG1 Fc Heterodimer combYSelect2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain | 著者 | Azzam, T, Du, J.J, Sundberg, E.J. | 登録日 | 2023-08-16 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers. Sci Adv, 10, 2024
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1GBV
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![BU of 1gbv by Molmil](/molmil-images/mine/1gbv) | (ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN | 分子名称: | HEMOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Vasquez, G.B, Ji, X, Pechik, I, Fronticelli, C, Gilliland, G.L. | 登録日 | 1995-12-20 | 公開日 | 1997-01-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Cysteines beta93 and beta112 as probes of conformational and functional events at the human hemoglobin subunit interfaces. Biophys.J., 76, 1999
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6CFF
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![BU of 6cff by Molmil](/molmil-images/mine/6cff) | Stimulator of Interferon Genes Human | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon genes protein | 著者 | Fernandez, D, Li, L, Ergun, S.L. | 登録日 | 2018-02-14 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell, 178, 2019
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6CY7
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![BU of 6cy7 by Molmil](/molmil-images/mine/6cy7) | Human Stimulator of Interferon Genes | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, GLYCEROL, IMIDAZOLE, ... | 著者 | Fernandez, D, Li, L, Ergun, S.L. | 登録日 | 2018-04-04 | 公開日 | 2019-03-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition. Cell, 178, 2019
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