PDB: 541 件ウェブページステータス検索Chemie searchBIRD

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5G4M	Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083 分子名称: 1,2-ETHANEDIOL, 1-[9-(2-fluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, ... 著者 Joerger, A.C, Bauer, M. 登録日 2016-05-13 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016
2GEQ	Crystal Structure of a p53 Core Dimer Bound to DNA 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*CP*GP*TP*GP*AP*GP*CP*AP*TP*GP*CP*TP*CP*AP*C)-3', Cellular tumor antigen p53, ... 著者 Ho, W.C, Fitzgerald, M.X, Marmorstein, R. 登録日 2006-03-20 公開日 2006-05-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the p53 Core Domain Dimer Bound to DNA. J.Biol.Chem., 281, 2006
6VQO	T cell receptor-p53-HLA-A2 complex 分子名称: Beta-2-microglobulin, MHC class I antigen, T-cell receptor 1a2, ... 著者 Wu, D, Gallagher, D.T, Pierce, B.G, Mariuzza, R.A. 登録日 2020-02-05 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. Nat Commun, 11, 2020
7DVD	The crystal structure of p53 DNA binding domain and PUMA complex 分子名称: Bcl-2-binding component 3, isoforms 1/2, Cellular tumor antigen p53, ... 著者 Han, C.W, Lee, H.N, Jeong, M.S, Jang, S.B. 登録日 2021-01-13 公開日 2021-08-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Structural basis of the p53 DNA binding domain and PUMA complex. Biochem.Biophys.Res.Commun., 548, 2021
7B4D	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... 著者 Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4E	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4F	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I) 分子名称: Cellular tumor antigen p53, DNA target, FORMIC ACID, ... 著者 Rozenberg, H, Degtjarik, O, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B49	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... 著者 Rozenberg, H, Degtjarik, O, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4G	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II) 分子名称: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4A	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA 分子名称: Cellular tumor antigen p53, DNA target, FORMIC ACID, ... 著者 Golovenko, D, Rozenberg, H, Degtjarik, O, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4H	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III) 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... 著者 Degtjarik, O, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B48	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) 分子名称: (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B47	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I) 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4B	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I) 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4N	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II) 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... 著者 Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B4C	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (II) 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
7B46	Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1) 分子名称: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, ACETATE ION, ... 著者 Degtjarik, O, Rozenberg, H, Shakked, Z. 登録日 2020-12-02 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
6FJ5	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG) 分子名称: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ... 著者 Golovenko, D, Rozenberg, H, Shakked, Z. 登録日 2018-01-20 公開日 2018-06-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.051 Å) 主引用文献 New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
5LGY	Lysine 120-acetylated P53 DNA binding domain in a complex with the BAX response element. 分子名称: Cellular tumor antigen p53, DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), ... 著者 Arbely, E, Vainer, R. 登録日 2016-07-08 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode. J.Mol.Biol., 428, 2016
5MCU	New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2) 分子名称: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ... 著者 Golovenko, D, Rozenberg, H, Shakked, Z. 登録日 2016-11-10 公開日 2018-06-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
7EAX	Crystal complex of p53-V272M and antimony ion 分子名称: ANTIMONY (III) ION, Cellular tumor antigen p53, ZINC ION 著者 Lu, M, Tang, Y. 登録日 2021-03-08 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Cell Rep, 39, 2022
5BUA	Lysine 120-acetylated P53 DNA binding domain in a complex with DNA. 分子名称: Cellular tumor antigen p53, DNA (5'-D(P*GP*GP*AP*CP*AP*TP*GP*TP*CP*C)-3'), ZINC ION 著者 Arbely, E, Vainer, R. 登録日 2015-06-03 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.812 Å) 主引用文献 Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode. J.Mol.Biol., 428, 2016
8HLN	Crystal structure of p53/BCL2 fusion complex(complex3) 分子名称: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION 著者 Guo, M, Wei, H, Wang, H, Chen, Y. 登録日 2022-11-30 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.354 Å) 主引用文献 Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HLM	Crystal structure of p53/BCL2 fusion complex (complex 2) 分子名称: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION 著者 Guo, M, Wang, H, Wei, H, Chen, Y. 登録日 2022-11-30 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.522 Å) 主引用文献 Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HLL	Crystal structure of p53/BCL2 fusion complex (complex 1) 分子名称: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION 著者 Wei, H, Guo, M, Wang, H, Chen, Y. 登録日 2022-11-30 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023

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