7B4B

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I)

Summary for 7B4B

Entry DOI	10.2210/pdb7b4b/pdb
Related	6ZNC 7B46 7B47 7B48 7B49 7B4A 7B4C 7B4D 7B4E 7B4F 7B4G 7B4H 7B4N
Descriptor	Cellular tumor antigen p53, ZINC ION, (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, ... (7 entities in total)
Functional Keywords	tumor suppressor, dna binding protein, protein dna complex, michael acceptor, michael reaction, protein-drug complex, protein-dna-drug complex, loop-sheet-helix motif, dna target, activator, transcription, hoogsteen base-pairing
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	91920.22
Authors	Degtjarik, O.,Rozenberg, H.,Shakked, Z. (deposition date: 2020-12-02, release date: 2021-12-08, Last modification date: 2024-01-31)
Primary citation	Degtjarik, O.,Golovenko, D.,Diskin-Posner, Y.,Abrahmsen, L.,Rozenberg, H.,Shakked, Z. Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12:7057-7057, 2021 Cited by PubMed: 34862374 DOI: 10.1038/s41467-021-27142-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation