7B4B
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Cellular tumor antigen p53 | polymer | 200 | 22451.5 | 4 | UniProt (P04637) Pfam (PF00870) In PDB | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B, C | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 4 | Chemie (QN8) | |||
| 4 | A, B, C, D | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 6 | Chemie (QNN) | |||
| 5 | A, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 7 | water | water | 18.0 | 635 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Cys 273 | Arg 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89806.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2114.1 | |
| All* | Total formula weight | 91920.2 |
