7B4F

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)

Summary for 7B4F

• Entry DOI: 10.2210/pdb7b4f/pdb
• Related: 6ZNC 7B46 7B47 7B48 7B49 7B4A 7B4B 7B4C 7B4D 7B4E 7B4G 7B4H 7B4N
• Descriptor: Cellular tumor antigen p53, DNA target, ZINC ION, ... (5 entities in total)
• Functional Keywords: p53, tumor suppressor, dna binding protein, protein dna complex, michael acceptor, michael reaction, protein-drug complex, protein-dna-drug complex, loop-sheet-helix motif, dna target, activator, transcription, hoogsteen base-pairing
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 26356.44

Authors

Rozenberg, H.,Degtjarik, O.,Shakked, Z. (deposition date: 2020-12-02, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Degtjarik, O.,Golovenko, D.,Diskin-Posner, Y.,Abrahmsen, L.,Rozenberg, H.,Shakked, Z.; Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).; Nat Commun, 12:7057-7057, 2021; PubMed: 34862374; DOI: 10.1038/s41467-021-27142-6

Experimental method

X-RAY DIFFRACTION (1.78 Å)