7B4F
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 200 | 22534.6 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | B (B) | DNA target | polymer | 12 | 3664.4 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Trp 282 | Arg 282 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26199.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 157.5 | |
| All* | Total formula weight | 26356.4 |
