5BUA
Lysine 120-acetylated P53 DNA binding domain in a complex with DNA.
Summary for 5BUA
Entry DOI | 10.2210/pdb5bua/pdb |
Descriptor | Cellular tumor antigen p53, DNA (5'-D(P*GP*GP*AP*CP*AP*TP*GP*TP*CP*C)-3'), ZINC ION, ... (4 entities in total) |
Functional Keywords | acetylation, transcription factor, post-translational modification, tumor suppressor, dna binding specificity, apoptosis, induced fit, genetic code expansion, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 25657.03 |
Authors | Arbely, E.,Vainer, R. (deposition date: 2015-06-03, release date: 2016-07-06, Last modification date: 2024-01-10) |
Primary citation | Vainer, R.,Cohen, S.,Shahar, A.,Zarivach, R.,Arbely, E. Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode. J.Mol.Biol., 428:3013-3025, 2016 Cited by PubMed: 27338200DOI: 10.1016/j.jmb.2016.06.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.812 Å) |
Structure validation
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