8TGY
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7NFD
| Structure of mitoxantrone-bound ABCG2 | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | 著者 | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | 登録日 | 2021-02-06 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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1R8E
| Crystal Structure of BmrR Bound to DNA at 2.4A Resolution | 分子名称: | 5'-D(*GP*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*TP*C)-3', GLYCEROL, IMIDAZOLE, ... | 著者 | Newberry, K.J, Brennan, R.G. | 登録日 | 2003-10-23 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J.Biol.Chem., 279, 2004
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6ETI
| Structure of inhibitor-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | 登録日 | 2017-10-26 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
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6FEQ
| Structure of inhibitor-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | 登録日 | 2018-01-03 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
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7NEQ
| Structure of tariquidar-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Kowal, J, Locher, K. | 登録日 | 2021-02-04 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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3D71
| Crystal structure of E253Q BMRR bound to 22 base pair promoter site | 分子名称: | BMR promoter DNA, CITRATE ANION, IMIDAZOLE, ... | 著者 | Newberry, K.J, Huffman, J.L, Brennan, R.G. | 登録日 | 2008-05-20 | 公開日 | 2008-08-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion J.Biol.Chem., 283, 2008
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6HIJ
| Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked | 分子名称: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATP-binding cassette sub-family G member 2, CHOLESTEROL, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | 登録日 | 2018-08-30 | 公開日 | 2018-09-19 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat.Struct.Mol.Biol., 25, 2018
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3QF4
| Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | 著者 | Hohl, M, Briand, C, Gruetter, M.G, Seeger, M.A. | 登録日 | 2011-01-21 | 公開日 | 2012-03-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation Nat.Struct.Mol.Biol., 19, 2012
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6GWH
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3MKT
| Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter | 分子名称: | Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump | 著者 | He, X, Szewczyk, P, Karyakin, A, Evin, M, Hong, W.-X, Zhang, Q, Chang, G. | 登録日 | 2010-04-15 | 公開日 | 2010-09-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature, 467, 2010
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3MKU
| Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter | 分子名称: | Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump, RUBIDIUM ION | 著者 | He, X, Szewczyk, P, Karyakin, A, Evin, M, Hong, W.-X, Zhang, Q, Chang, G. | 登録日 | 2010-04-15 | 公開日 | 2010-09-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature, 467, 2010
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5MKK
| Crystal structure of the heterodimeric ABC transporter TmrAB, a homolog of the antigen translocation complex TAP | 分子名称: | Multidrug resistance ABC transporter ATP-binding and permease protein, SULFATE ION | 著者 | Noell, A, Thomas, C, Tomasiak, T.M, Olieric, V, Wang, M, Diederichs, K, Stroud, R.M, Pos, K.M, Tampe, R. | 登録日 | 2016-12-05 | 公開日 | 2017-01-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2ONJ
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8CHB
| Inward-facing conformation of the ABC transporter BmrA C436S/A582C cross-linked mutant | 分子名称: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | 著者 | Di Cesare, M, Kaplan, E, Hanssen, E, Valimehr, S, Orelle, C, Jault, J.M. | 登録日 | 2023-02-07 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains. J.Biol.Chem., 300, 2023
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8QOE
| Inward-facing conformation of the ABC transporter BmrA | 分子名称: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | 著者 | Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M. | 登録日 | 2023-09-28 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains. J.Biol.Chem., 300, 2023
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7OW8
| CryoEM structure of the ABC transporter BmrA E504A mutant in complex with ATP-Mg | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | 著者 | Gobet, A, Schoehn, G, Falson, P, Chaptal, V. | 登録日 | 2021-06-17 | 公開日 | 2022-01-19 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
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5V5S
| multi-drug efflux; membrane transport; RND superfamily; Drug resistance | 分子名称: | Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, Outer membrane protein TolC | 著者 | wang, Z, fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | 登録日 | 2017-03-15 | 公開日 | 2017-04-19 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
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2V4D
| Re-refinement of MexA adaptor protein | 分子名称: | MULTIDRUG RESISTANCE PROTEIN MEXA, SULFATE ION | 著者 | Symmons, M.F, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V. | 登録日 | 2008-09-18 | 公開日 | 2009-04-14 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The Assembled Structure of a Complete Tripartite Bacterial Multidrug Efflux Pump. Proc.Natl.Acad.Sci.USA, 106, 2009
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5YIL
| Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains | 分子名称: | Multidrug efflux pump subunit AcrB | 著者 | Zwama, M, Sakurai, K, Hayashi, K, Nakashima, R, Kitagawa, K, Nishino, K, Yamaguchi, A. | 登録日 | 2017-10-05 | 公開日 | 2017-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains. Front Microbiol, 8, 2017
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8JWG
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8JWI
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8JWF
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6GV1
| Crystal structure of E.coli Multidrug/H+ antiporter MdfA in outward open conformation with bound Fab fragment | 分子名称: | Fab fragment YN1074 heavy chain, Fab fragment YN1074 light chain, Major Facilitator Superfamily multidrug/H+ antiporter MdfA from E.coli, ... | 著者 | Nagarathinam, K, Parthier, C, Stubbs, M.T, Tanabe, M. | 登録日 | 2018-06-20 | 公開日 | 2018-10-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Outward open conformation of a Major Facilitator Superfamily multidrug/H+antiporter provides insights into switching mechanism. Nat Commun, 9, 2018
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7JK8
| EmrE S64V mutant bound to tetra(4-fluorophenyl)phosphonium at pH 5.8 | 分子名称: | Multidrug SMR transporter, tetrakis(4-fluorophenyl)phosphanium | 著者 | Shcherbakov, A.A, Hisao, G, Mandala, V.S, Thomas, N.E, Soltani, M, Salter, E.A, Davis Jr, J.H, Henzler-Wildman, K.A, Hong, M. | 登録日 | 2020-07-27 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers. Nat Commun, 12, 2021
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