6VEJ
| TriABC transporter from Pseudomonas aeruginosa | 分子名称: | (2R)-2-(hexadecanoyloxy)propyl nonadecanoate, DODECYL-ALPHA-D-MALTOSIDE, PALMITIC ACID, ... | 著者 | Sygusch, J, Fabre, L, Rouiller, I, Bhattacharyya, S. | 登録日 | 2020-01-02 | 公開日 | 2020-09-30 | 最終更新日 | 2021-03-17 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure, 29, 2021
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6VKS
| Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of drug recognition with ampicillin | 分子名称: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE | 著者 | Moseng, M.A, Lyu, M. | 登録日 | 2020-01-22 | 公開日 | 2020-07-01 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance. Mbio, 11, 2020
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6VKT
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6Z12
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6ZO5
| Fusidic acid binding to the TM1/TM2 groove of AcrB-G619P_G621P | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZO6
| Minocycline binding to the deep binding pocket of AcrB-G619P | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZO7
| 3-Formylrifamycin SV binding to the access pocket of AcrB-G619P L and T protomer | 分子名称: | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZO8
| Minocycline binding to the deep binding pocket of AcrB-G621P | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZO9
| Binding of two rifabutins to the access pocket of AcrB-G621P T protomer | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOA
| Partially induced AcrB T protomer and DDM binding to the TM8/PC2 pathway of AcrB L2 protomer | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DARPIN, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOB
| 3-Formylrifamycin SV binding to the access pocket of AcrB L protomer | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOC
| Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer | 分子名称: | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, DARPIN, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOD
| Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8 groove, and TM1/TM2 groove of the fully induced AcrB T protomer | 分子名称: | 1,2-ETHANEDIOL, DARPIN, DECANE, ... | 著者 | Oswald, C, Tam, H.K, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOE
| AcrB-F563A symmetric T protomer | 分子名称: | 1,2-ETHANEDIOL, DARPIN, DECANE, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOF
| Fusidic acid binding to the TM7/TM8 groove of AcrB-F380A T protomer | 分子名称: | DARPIN, DECANE, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOG
| Minocycline binding to the deep binding pocket of AcrB-I38F_I671T | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, 1,2-ETHANEDIOL, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOH
| 3-Formylrifamycin SV binding to the access pocket of AcrB-G619P_G621P L and T protomers | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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7B5P
| AcrB in cycloalkane amphipol | 分子名称: | Efflux pump membrane transporter | 著者 | Higgins, A.J, Flynn, A.J, Muench, S.P. | 登録日 | 2020-12-05 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis. Commun Biol, 4, 2021
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7B8R
| Doxycycline bound structure of bacterial efflux pump. | 分子名称: | (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8S
| Fusidic acid bound structure of bacterial efflux pump. | 分子名称: | DARPin, FUSIDIC ACID, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7B8T
| Levofloxacin bound structure of bacterial efflux pump. | 分子名称: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Wilhelm, J, Sjuts, H, Pos, K.M. | 登録日 | 2020-12-13 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms. Nat Commun, 12, 2021
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7CZ9
| Crystal structure of multidrug efflux transporter OqxB from Klebsiella pneumoniae | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter, GLYCEROL, ... | 著者 | Murakami, S, Okada, U, Yamashita, E. | 登録日 | 2020-09-07 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae. Nat Commun, 12, 2021
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7KF5
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7KF6
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7KF7
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