6ZOC

Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer

Summary for 6ZOC

• Entry DOI: 10.2210/pdb6zoc/pdb
• Descriptor: Multidrug efflux pump subunit AcrB, HEXANE, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, ... (16 entities in total)
• Functional Keywords: multidrug efflux pump, membrane protein, transport protein
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 5
• Total formula weight: 388642.25

Authors

Tam, H.K.,Foong, W.E.,Pos, K.M. (deposition date: 2020-07-07, release date: 2021-05-19, Last modification date: 2024-01-31)

• Primary citation: Tam, H.K.,Foong, W.E.,Oswald, C.,Herrmann, A.,Zeng, H.,Pos, K.M.; Allosteric drug transport mechanism of multidrug transporter AcrB.; Nat Commun, 12:3889-3889, 2021; PubMed: 34188038; DOI: 10.1038/s41467-021-24151-3

Experimental method

X-RAY DIFFRACTION (2.89 Å)