Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZOC

Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015567	molecular_function	alkane transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015895	biological_process	alkane transport
A	0015908	biological_process	fatty acid transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015567	molecular_function	alkane transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015895	biological_process	alkane transport
B	0015908	biological_process	fatty acid transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015567	molecular_function	alkane transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0015895	biological_process	alkane transport
C	0015908	biological_process	fatty acid transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue C14 A 1201

Chain	Residue
A	LEU28
A	VAL341
A	PHE380

site_id	AC2
Number of Residues	6
Details	binding site for residue LMT A 1202

Chain	Residue
A	GLY440
A	CYS887
A	ALA890
A	LEU891
C	ARG8
C	PHE11

site_id	AC3
Number of Residues	14
Details	binding site for residue ERY A 1203

Chain	Residue
A	SER79
A	SER134
A	SER135
A	PHE136
A	LYS292
A	MET573
A	PHE615
A	VAL672
A	ASP681
A	GLU683
A	ASN719
A	GLU826
A	GLY861
A	MET862

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 1204

Chain	Residue
A	SER233
B	THR724

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 1205

Chain	Residue
A	SER530
A	TYR541

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL A 1206

Chain	Residue
A	ARG185
A	GLU273
A	ASN274
A	GLY755
A	GLY756
A	TYR772
A	MET774

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 1207

Chain	Residue
A	GLU567
A	ASP568
A	GLY994
A	SER997

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 1208

Chain	Residue
A	GLN588
C	LYS226

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO A 1209

Chain	Residue
A	ARG168
B	ASN820

site_id	AD1
Number of Residues	2
Details	binding site for residue D12 A 1210

Chain	Residue
A	TRP895
C	TRP13

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL A 1211

Chain	Residue
A	ILE743
A	ASN744
A	ASN747
A	EDO1212
C	LYS208
C	GLN237

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO A 1212

Chain	Residue
A	ASN744
A	GOL1211

site_id	AD4
Number of Residues	9
Details	binding site for residue LMT B 1101

Chain	Residue
B	SER530
B	GLY533
B	ILE534
B	ARG536
B	SER537
B	ARG540
B	TYR541
B	PHE1020
D	ASP72

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO B 1102

Chain	Residue
B	ARG239
B	TYR758
B	ASP761
C	GLU121

site_id	AD6
Number of Residues	1
Details	binding site for residue OCT B 1103

Chain	Residue
B	PHE4

site_id	AD7
Number of Residues	3
Details	binding site for residue HEX B 1104

Chain	Residue
B	TYR877
B	SER880
B	LEU932

site_id	AD8
Number of Residues	6
Details	binding site for residue LMT B 1105

Chain	Residue
B	ILE27
B	ASN298
B	LEU300
B	ASP301
B	LYS334
B	ILE390

site_id	AD9
Number of Residues	9
Details	binding site for residue 3YI B 1107

Chain	Residue
B	MET575
B	PHE617
B	ALA618
B	PHE664
B	PHE666
B	THR676
B	ARG717
B	ASN719
B	ARG815

site_id	AE1
Number of Residues	7
Details	binding site for residue DDQ B 1108

Chain	Residue
B	PHE4
B	PHE11
B	VAL14
B	ILE18
B	HOH1213
C	LEU891
C	HEX1114

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 B 1109

Chain	Residue
B	LYS55
B	GLY691
B	HIS692
B	GLU693

site_id	AE3
Number of Residues	7
Details	binding site for residue LMT C 1101

Chain	Residue
C	SER537
C	ARG540
C	TYR541
C	SER530
C	GLY533
C	ILE534
C	ARG536

site_id	AE4
Number of Residues	2
Details	binding site for residue OCT C 1102

Chain	Residue
C	GLN439
C	HEX1114

site_id	AE5
Number of Residues	3
Details	binding site for residue C14 C 1103

Chain	Residue
C	PHE458
C	PHE459
C	GLN872

site_id	AE6
Number of Residues	5
Details	binding site for residue PG4 C 1104

Chain	Residue
B	ARG168
C	LEU75
C	MET76
C	MET78
C	ASN820

site_id	AE7
Number of Residues	7
Details	binding site for residue GOL C 1105

Chain	Residue
A	ALA688
A	GLY689
C	ALA160
C	ASN161
C	ASP764
C	ARG765
C	LYS769

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL C 1106

Chain	Residue
A	LEU75
A	MET76
A	ASN820
C	ALA165
C	ARG168
C	GLU309

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO C 1107

Chain	Residue
C	VAL225
C	LYS226
C	ASN282

site_id	AF1
Number of Residues	3
Details	binding site for residue LMT C 1108

Chain	Residue
C	ILE19
C	LYS29
C	ALA384

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO C 1109

Chain	Residue
C	SER46
C	GLN125
C	GLY126
C	SER128

site_id	AF3
Number of Residues	3
Details	binding site for residue EDO C 1110

Chain	Residue
C	PRO560
C	SER561
C	HOH1218

site_id	AF4
Number of Residues	1
Details	binding site for residue EDO C 1111

Chain	Residue
C	ARG792

site_id	AF5
Number of Residues	2
Details	binding site for residue EDO C 1112

Chain	Residue
C	PHE136
C	MET573

site_id	AF6
Number of Residues	5
Details	binding site for residue PTY C 1113

Chain	Residue
B	TRP13
C	SER894
C	TRP895
C	SER896
C	ARG1030

site_id	AF7
Number of Residues	2
Details	binding site for residue HEX C 1114

Chain	Residue
B	DDQ1108
C	OCT1102

site_id	AF8
Number of Residues	4
Details	binding site for residue SO4 D 201

Chain	Residue
B	GLU693
D	TYR56
D	TRP57
D	PHE90

site_id	AF9
Number of Residues	2
Details	binding site for residue EDO E 201

Chain	Residue
E	ALA75
E	TYR76

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	462
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	MET1-PRO9
B	GLU414-ILE438
B	ALA491-THR538
B	ALA889-PRO898
B	LEU944-LEU972
B	ILE1019-HIS1049
C	MET1-PRO9
C	LEU357-THR365
C	GLU414-ILE438
C	ALA491-THR538
C	ALA889-PRO898
A	LEU357-THR365
C	LEU944-LEU972
C	ILE1019-HIS1049
A	GLU414-ILE438
A	ALA491-THR538
A	ALA889-PRO898
A	LEU944-LEU972
A	ILE1019-HIS1049
B	MET1-PRO9
B	LEU357-THR365

site_id	SWS_FT_FI2
Number of Residues	54
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ILE10-LEU28
B	ILE10-LEU28
C	ILE10-LEU28

site_id	SWS_FT_FI3
Number of Residues	1932
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	LYS29-SER336
B	PHE556-ASN871
B	ARG919-ASP924
B	THR993-GLY998
C	LYS29-SER336
C	PHE386-ASN391
C	PHE458-ALA465
C	PHE556-ASN871
C	ARG919-ASP924
C	THR993-GLY998
A	PHE386-ASN391
A	PHE458-ALA465
A	PHE556-ASN871
A	ARG919-ASP924
A	THR993-GLY998
B	LYS29-SER336
B	PHE386-ASN391
B	PHE458-ALA465

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ILE337-TYR356
B	ILE337-TYR356
C	ILE337-TYR356

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU366-ALA385
B	LEU366-ALA385
C	LEU366-ALA385

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR392-VAL413
B	THR392-VAL413
C	THR392-VAL413

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLN439-ALA457
B	GLN439-ALA457
C	GLN439-ALA457

site_id	SWS_FT_FI8
Number of Residues	72
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ILE466-PRO490
B	ILE466-PRO490
C	ILE466-PRO490

site_id	SWS_FT_FI9
Number of Residues	48
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	GLY539-LEU555
B	GLY539-LEU555
C	GLY539-LEU555

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLN872-LEU888
B	GLN872-LEU888
C	GLN872-LEU888

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	PHE899-PHE918
B	PHE899-PHE918
C	PHE899-PHE918

site_id	SWS_FT_FI12
Number of Residues	54
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	VAL925-ILE943
B	VAL925-ILE943
C	VAL925-ILE943

site_id	SWS_FT_FI13
Number of Residues	57
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ARG973-SER992
B	ARG973-SER992
C	ARG973-SER992

site_id	SWS_FT_FI14
Number of Residues	57
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	ALA999-ALA1018
B	ALA999-ALA1018
C	ALA999-ALA1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)