6ZOC
Erythromycin binding to the access pocket of AcrB-G616P L protomer and 3-formylrifamycin SV binding to the access pocket of AcrB-G616P T protomer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue C14 A 1201 |
| Chain | Residue |
| A | LEU28 |
| A | VAL341 |
| A | PHE380 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue LMT A 1202 |
| Chain | Residue |
| A | GLY440 |
| A | CYS887 |
| A | ALA890 |
| A | LEU891 |
| C | ARG8 |
| C | PHE11 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue ERY A 1203 |
| Chain | Residue |
| A | SER79 |
| A | SER134 |
| A | SER135 |
| A | PHE136 |
| A | LYS292 |
| A | MET573 |
| A | PHE615 |
| A | VAL672 |
| A | ASP681 |
| A | GLU683 |
| A | ASN719 |
| A | GLU826 |
| A | GLY861 |
| A | MET862 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1204 |
| Chain | Residue |
| A | SER233 |
| B | THR724 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1205 |
| Chain | Residue |
| A | SER530 |
| A | TYR541 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1206 |
| Chain | Residue |
| A | ARG185 |
| A | GLU273 |
| A | ASN274 |
| A | GLY755 |
| A | GLY756 |
| A | TYR772 |
| A | MET774 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1207 |
| Chain | Residue |
| A | GLU567 |
| A | ASP568 |
| A | GLY994 |
| A | SER997 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1208 |
| Chain | Residue |
| A | GLN588 |
| C | LYS226 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1209 |
| Chain | Residue |
| A | ARG168 |
| B | ASN820 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue D12 A 1210 |
| Chain | Residue |
| A | TRP895 |
| C | TRP13 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1211 |
| Chain | Residue |
| A | ILE743 |
| A | ASN744 |
| A | ASN747 |
| A | EDO1212 |
| C | LYS208 |
| C | GLN237 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1212 |
| Chain | Residue |
| A | ASN744 |
| A | GOL1211 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue LMT B 1101 |
| Chain | Residue |
| B | SER530 |
| B | GLY533 |
| B | ILE534 |
| B | ARG536 |
| B | SER537 |
| B | ARG540 |
| B | TYR541 |
| B | PHE1020 |
| D | ASP72 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1102 |
| Chain | Residue |
| B | ARG239 |
| B | TYR758 |
| B | ASP761 |
| C | GLU121 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue OCT B 1103 |
| Chain | Residue |
| B | PHE4 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue HEX B 1104 |
| Chain | Residue |
| B | TYR877 |
| B | SER880 |
| B | LEU932 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue LMT B 1105 |
| Chain | Residue |
| B | ILE27 |
| B | ASN298 |
| B | LEU300 |
| B | ASP301 |
| B | LYS334 |
| B | ILE390 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue 3YI B 1107 |
| Chain | Residue |
| B | MET575 |
| B | PHE617 |
| B | ALA618 |
| B | PHE664 |
| B | PHE666 |
| B | THR676 |
| B | ARG717 |
| B | ASN719 |
| B | ARG815 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue DDQ B 1108 |
| Chain | Residue |
| B | PHE4 |
| B | PHE11 |
| B | VAL14 |
| B | ILE18 |
| B | HOH1213 |
| C | LEU891 |
| C | HEX1114 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1109 |
| Chain | Residue |
| B | LYS55 |
| B | GLY691 |
| B | HIS692 |
| B | GLU693 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue LMT C 1101 |
| Chain | Residue |
| C | SER537 |
| C | ARG540 |
| C | TYR541 |
| C | SER530 |
| C | GLY533 |
| C | ILE534 |
| C | ARG536 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue OCT C 1102 |
| Chain | Residue |
| C | GLN439 |
| C | HEX1114 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue C14 C 1103 |
| Chain | Residue |
| C | PHE458 |
| C | PHE459 |
| C | GLN872 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue PG4 C 1104 |
| Chain | Residue |
| B | ARG168 |
| C | LEU75 |
| C | MET76 |
| C | MET78 |
| C | ASN820 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 1105 |
| Chain | Residue |
| A | ALA688 |
| A | GLY689 |
| C | ALA160 |
| C | ASN161 |
| C | ASP764 |
| C | ARG765 |
| C | LYS769 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 1106 |
| Chain | Residue |
| A | LEU75 |
| A | MET76 |
| A | ASN820 |
| C | ALA165 |
| C | ARG168 |
| C | GLU309 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 1107 |
| Chain | Residue |
| C | VAL225 |
| C | LYS226 |
| C | ASN282 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue LMT C 1108 |
| Chain | Residue |
| C | ILE19 |
| C | LYS29 |
| C | ALA384 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 1109 |
| Chain | Residue |
| C | SER46 |
| C | GLN125 |
| C | GLY126 |
| C | SER128 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 1110 |
| Chain | Residue |
| C | PRO560 |
| C | SER561 |
| C | HOH1218 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 1111 |
| Chain | Residue |
| C | ARG792 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1112 |
| Chain | Residue |
| C | PHE136 |
| C | MET573 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue PTY C 1113 |
| Chain | Residue |
| B | TRP13 |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | ARG1030 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue HEX C 1114 |
| Chain | Residue |
| B | DDQ1108 |
| C | OCT1102 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 201 |
| Chain | Residue |
| B | GLU693 |
| D | TYR56 |
| D | TRP57 |
| D | PHE90 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO E 201 |
| Chain | Residue |
| E | ALA75 |
| E | TYR76 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
