6ZO6

Minocycline binding to the deep binding pocket of AcrB-G619P

Summary for 6ZO6

Entry DOI	10.2210/pdb6zo6/pdb
Descriptor	Multidrug efflux pump subunit AcrB, TRIETHYLENE GLYCOL, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ... (24 entities in total)
Functional Keywords	multidrug efflux pump, membrane protein, transport protein
Biological source	Escherichia coli K-12 More
Total number of polymer chains	5
Total formula weight	393980.80
Authors	Tam, H.K.,Foong, W.E.,Pos, K.M. (deposition date: 2020-07-07, release date: 2021-05-19, Last modification date: 2024-01-31)
Primary citation	Tam, H.K.,Foong, W.E.,Oswald, C.,Herrmann, A.,Zeng, H.,Pos, K.M. Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12:3889-3889, 2021 Cited by PubMed: 34188038 DOI: 10.1038/s41467-021-24151-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation