6ZO6
Minocycline binding to the deep binding pocket of AcrB-G619P
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0009636 | biological_process | response to toxic substance |
A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
A | 0015562 | molecular_function | efflux transmembrane transporter activity |
A | 0015567 | molecular_function | alkane transmembrane transporter activity |
A | 0015721 | biological_process | bile acid and bile salt transport |
A | 0015895 | biological_process | alkane transport |
A | 0015908 | biological_process | fatty acid transport |
A | 0016020 | cellular_component | membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0042908 | biological_process | xenobiotic transport |
A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
A | 0042930 | biological_process | enterobactin transport |
A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
A | 0046677 | biological_process | response to antibiotic |
A | 0055085 | biological_process | transmembrane transport |
A | 0098567 | cellular_component | periplasmic side of plasma membrane |
A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
A | 1990281 | cellular_component | efflux pump complex |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0009636 | biological_process | response to toxic substance |
B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
B | 0015562 | molecular_function | efflux transmembrane transporter activity |
B | 0015567 | molecular_function | alkane transmembrane transporter activity |
B | 0015721 | biological_process | bile acid and bile salt transport |
B | 0015895 | biological_process | alkane transport |
B | 0015908 | biological_process | fatty acid transport |
B | 0016020 | cellular_component | membrane |
B | 0022857 | molecular_function | transmembrane transporter activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0042908 | biological_process | xenobiotic transport |
B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
B | 0042930 | biological_process | enterobactin transport |
B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
B | 0046677 | biological_process | response to antibiotic |
B | 0055085 | biological_process | transmembrane transport |
B | 0098567 | cellular_component | periplasmic side of plasma membrane |
B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
B | 1990281 | cellular_component | efflux pump complex |
C | 0005515 | molecular_function | protein binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0009410 | biological_process | response to xenobiotic stimulus |
C | 0009636 | biological_process | response to toxic substance |
C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
C | 0015562 | molecular_function | efflux transmembrane transporter activity |
C | 0015567 | molecular_function | alkane transmembrane transporter activity |
C | 0015721 | biological_process | bile acid and bile salt transport |
C | 0015895 | biological_process | alkane transport |
C | 0015908 | biological_process | fatty acid transport |
C | 0016020 | cellular_component | membrane |
C | 0022857 | molecular_function | transmembrane transporter activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0042908 | biological_process | xenobiotic transport |
C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
C | 0042930 | biological_process | enterobactin transport |
C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
C | 0046677 | biological_process | response to antibiotic |
C | 0055085 | biological_process | transmembrane transport |
C | 0098567 | cellular_component | periplasmic side of plasma membrane |
C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue LMT A 1101 |
Chain | Residue |
A | LEU28 |
A | VAL32 |
A | VAL341 |
A | ILE348 |
A | PHE380 |
A | HOH1202 |
B | 8K61131 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue LMT A 1102 |
Chain | Residue |
A | CYS887 |
A | LEU891 |
C | ARG8 |
A | GLY440 |
A | GLY444 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue LMT A 1103 |
Chain | Residue |
A | SER530 |
A | GLY533 |
A | ARG536 |
A | ARG540 |
A | TYR541 |
A | HOH1341 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue DDQ A 1105 |
Chain | Residue |
A | PHE386 |
A | ARG468 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue GOL A 1106 |
Chain | Residue |
A | GLY51 |
A | GLY755 |
A | MET774 |
A | GOL1107 |
A | HOH1204 |
A | HOH1307 |
A | HOH1382 |
C | GLY221 |
C | THR222 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue GOL A 1107 |
Chain | Residue |
A | PRO50 |
A | ARG185 |
A | GLU273 |
A | GLY755 |
A | TYR772 |
A | MET774 |
A | GOL1106 |
A | HOH1203 |
A | HOH1307 |
A | HOH1347 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue GOL A 1108 |
Chain | Residue |
A | ALA47 |
A | SER48 |
A | GLY126 |
A | SER128 |
A | EDO1115 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue GOL A 1109 |
Chain | Residue |
A | ASP566 |
A | GLU567 |
A | ASP568 |
A | LYS643 |
A | GLY998 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue GOL A 1110 |
Chain | Residue |
A | GLU593 |
A | HIS596 |
A | TYR597 |
A | LYS601 |
A | HOH1424 |
B | GLY227 |
B | GLN229 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue GOL A 1111 |
Chain | Residue |
A | SER742 |
A | ILE743 |
A | ASN744 |
A | HOH1333 |
site_id | AD2 |
Number of Residues | 1 |
Details | binding site for residue D12 A 1112 |
Chain | Residue |
A | TRP895 |
site_id | AD3 |
Number of Residues | 1 |
Details | binding site for residue HEX A 1113 |
Chain | Residue |
A | PHE885 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue EDO A 1114 |
Chain | Residue |
A | PRO36 |
A | THR37 |
A | SER389 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue EDO A 1115 |
Chain | Residue |
A | SER128 |
A | GLU130 |
A | GLN176 |
A | GOL1108 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue EDO A 1116 |
Chain | Residue |
A | THR243 |
A | ARG263 |
A | HOH1464 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue PGE A 1117 |
Chain | Residue |
A | ASN144 |
A | THR148 |
A | MET149 |
A | ASP153 |
A | ASP156 |
A | SER319 |
A | ARG765 |
site_id | AD8 |
Number of Residues | 9 |
Details | binding site for residue MIY B 1101 |
Chain | Residue |
B | PHE178 |
B | GLY179 |
B | SER180 |
B | ASN274 |
B | ASP276 |
B | ILE277 |
B | ALA279 |
B | PHE615 |
B | HOH1272 |
site_id | AD9 |
Number of Residues | 10 |
Details | binding site for residue LMT B 1102 |
Chain | Residue |
B | SER530 |
B | GLY533 |
B | ILE534 |
B | ARG536 |
B | SER537 |
B | TYR541 |
B | PHE1020 |
B | D101107 |
B | HOH1278 |
D | ASP72 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue LMT B 1103 |
Chain | Residue |
B | LYS509 |
B | LYS510 |
B | PHE512 |
B | TRP515 |
B | ARG518 |
B | GLY508 |
site_id | AE2 |
Number of Residues | 10 |
Details | binding site for residue DDR B 1104 |
Chain | Residue |
B | VAL452 |
B | PHE459 |
B | TYR467 |
B | MET552 |
B | TYR877 |
B | SER880 |
B | LEU881 |
B | VAL905 |
B | GLN928 |
B | LEU931 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue DDQ B 1106 |
Chain | Residue |
A | TRP13 |
B | TRP895 |
site_id | AE4 |
Number of Residues | 1 |
Details | binding site for residue D10 B 1107 |
Chain | Residue |
B | LMT1102 |
site_id | AE5 |
Number of Residues | 2 |
Details | binding site for residue D10 B 1108 |
Chain | Residue |
B | ASN298 |
B | ASP301 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue D10 B 1109 |
Chain | Residue |
B | PHE11 |
C | MET447 |
C | CYS887 |
site_id | AE7 |
Number of Residues | 8 |
Details | binding site for residue GOL B 1110 |
Chain | Residue |
A | ARG168 |
A | GLU309 |
A | HOH1286 |
B | LEU75 |
B | MET76 |
B | TYR77 |
B | MET78 |
B | ASN820 |
site_id | AE8 |
Number of Residues | 7 |
Details | binding site for residue GOL B 1111 |
Chain | Residue |
B | PHE358 |
B | LEU359 |
B | GLN360 |
B | ILE500 |
B | ASP504 |
B | GLY506 |
B | LYS509 |
site_id | AE9 |
Number of Residues | 4 |
Details | binding site for residue GOL B 1112 |
Chain | Residue |
B | GLU593 |
B | TYR597 |
B | ALA654 |
B | ILE658 |
site_id | AF1 |
Number of Residues | 2 |
Details | binding site for residue GOL B 1113 |
Chain | Residue |
B | THR238 |
C | LYS728 |
site_id | AF2 |
Number of Residues | 2 |
Details | binding site for residue CL B 1114 |
Chain | Residue |
B | HIS692 |
B | HOH1290 |
site_id | AF3 |
Number of Residues | 1 |
Details | binding site for residue HEX B 1115 |
Chain | Residue |
B | ALA384 |
site_id | AF4 |
Number of Residues | 2 |
Details | binding site for residue MYS B 1119 |
Chain | Residue |
B | PHE885 |
B | PHE899 |
site_id | AF5 |
Number of Residues | 12 |
Details | binding site for residue PG4 B 1120 |
Chain | Residue |
A | ASN109 |
B | GLN108 |
B | GLN112 |
B | MET115 |
B | GLY126 |
B | VAL127 |
B | HOH1378 |
C | GLN108 |
C | GLN112 |
C | MET115 |
C | VAL127 |
C | VAL129 |
site_id | AF6 |
Number of Residues | 2 |
Details | binding site for residue EDO B 1121 |
Chain | Residue |
B | GLU810 |
B | TYR811 |
site_id | AF7 |
Number of Residues | 3 |
Details | binding site for residue EDO B 1122 |
Chain | Residue |
B | ASN700 |
D | ARG23 |
D | TRP57 |
site_id | AF8 |
Number of Residues | 2 |
Details | binding site for residue EDO B 1123 |
Chain | Residue |
B | GLY856 |
B | TYR857 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue EDO B 1124 |
Chain | Residue |
A | HOH1236 |
B | ARG185 |
B | GLU273 |
B | ASN274 |
B | MET774 |
site_id | AG1 |
Number of Residues | 3 |
Details | binding site for residue EDO B 1125 |
Chain | Residue |
B | ASN189 |
B | ARG263 |
B | ASP264 |
site_id | AG2 |
Number of Residues | 5 |
Details | binding site for residue EDO B 1126 |
Chain | Residue |
B | SER46 |
B | SER48 |
B | GLN125 |
B | GLY126 |
B | SER128 |
site_id | AG3 |
Number of Residues | 2 |
Details | binding site for residue EDO B 1127 |
Chain | Residue |
B | HIS505 |
B | ARG973 |
site_id | AG4 |
Number of Residues | 4 |
Details | binding site for residue EDO B 1128 |
Chain | Residue |
A | ALA209 |
B | ILE743 |
B | ASN744 |
B | ASN747 |
site_id | AG5 |
Number of Residues | 4 |
Details | binding site for residue EDO B 1129 |
Chain | Residue |
B | ASN760 |
B | ASP761 |
C | GLN120 |
C | GLU121 |
site_id | AG6 |
Number of Residues | 7 |
Details | binding site for residue EDO B 1130 |
Chain | Residue |
B | PHE727 |
B | PRO783 |
B | ILE786 |
B | SER802 |
B | SER805 |
B | SER807 |
B | HOH1368 |
site_id | AG7 |
Number of Residues | 1 |
Details | binding site for residue 8K6 B 1131 |
Chain | Residue |
A | LMT1101 |
site_id | AG8 |
Number of Residues | 3 |
Details | binding site for residue R16 B 1132 |
Chain | Residue |
B | LYS29 |
C | VAL454 |
C | SER875 |
site_id | AG9 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 1133 |
Chain | Residue |
B | ASN361 |
B | PHE362 |
B | ARG363 |
B | LYS498 |
site_id | AH1 |
Number of Residues | 1 |
Details | binding site for residue C14 C 1101 |
Chain | Residue |
C | TYR892 |
site_id | AH2 |
Number of Residues | 6 |
Details | binding site for residue LMT C 1102 |
Chain | Residue |
C | SER530 |
C | GLY533 |
C | ARG536 |
C | SER537 |
C | TYR541 |
C | DDQ1106 |
site_id | AH3 |
Number of Residues | 7 |
Details | binding site for residue PTY C 1103 |
Chain | Residue |
B | TRP13 |
C | GLU893 |
C | SER894 |
C | TRP895 |
C | SER896 |
C | PHE1033 |
C | SER1034 |
site_id | AH4 |
Number of Residues | 1 |
Details | binding site for residue OCT C 1104 |
Chain | Residue |
C | PHE380 |
site_id | AH5 |
Number of Residues | 3 |
Details | binding site for residue OCT C 1105 |
Chain | Residue |
C | PHE458 |
C | ARG468 |
C | LPX1119 |
site_id | AH6 |
Number of Residues | 2 |
Details | binding site for residue DDQ C 1106 |
Chain | Residue |
C | SER530 |
C | LMT1102 |
site_id | AH7 |
Number of Residues | 2 |
Details | binding site for residue D10 C 1108 |
Chain | Residue |
C | PHE556 |
C | VAL557 |
site_id | AH8 |
Number of Residues | 1 |
Details | binding site for residue D10 C 1109 |
Chain | Residue |
C | ALA384 |
site_id | AH9 |
Number of Residues | 7 |
Details | binding site for residue GOL C 1110 |
Chain | Residue |
B | HOH1354 |
C | ARG185 |
C | GLU273 |
C | GLY755 |
C | GLY756 |
C | TYR772 |
C | HOH1401 |
site_id | AI1 |
Number of Residues | 5 |
Details | binding site for residue GOL C 1111 |
Chain | Residue |
A | VAL64 |
C | TYR758 |
C | ASP761 |
C | LYS770 |
C | HOH1244 |
site_id | AI2 |
Number of Residues | 2 |
Details | binding site for residue CL C 1113 |
Chain | Residue |
C | LYS950 |
C | ARG1030 |
site_id | AI3 |
Number of Residues | 1 |
Details | binding site for residue D12 C 1115 |
Chain | Residue |
C | PHE4 |
site_id | AI4 |
Number of Residues | 2 |
Details | binding site for residue HEX C 1117 |
Chain | Residue |
C | ALA385 |
C | LPX1119 |
site_id | AI5 |
Number of Residues | 10 |
Details | binding site for residue LPX C 1119 |
Chain | Residue |
C | PHE388 |
C | ALA457 |
C | ARG468 |
C | GLN469 |
C | SER471 |
C | SER476 |
C | LEU480 |
C | OCT1105 |
C | HEX1117 |
C | HOH1286 |
site_id | AI6 |
Number of Residues | 12 |
Details | binding site for residue 1PE C 1120 |
Chain | Residue |
C | GLU339 |
C | ASP566 |
C | GLU567 |
C | ASP568 |
C | TRP634 |
C | LYS643 |
C | THR993 |
C | GLY994 |
C | ALA995 |
C | SER997 |
C | HOH1292 |
C | HOH1299 |
site_id | AI7 |
Number of Residues | 2 |
Details | binding site for residue EDO C 1121 |
Chain | Residue |
C | GLY283 |
C | GLN284 |
site_id | AI8 |
Number of Residues | 4 |
Details | binding site for residue EDO C 1122 |
Chain | Residue |
C | GLU607 |
C | SER630 |
C | LEU631 |
C | ASP633 |
site_id | AI9 |
Number of Residues | 2 |
Details | binding site for residue EDO C 1123 |
Chain | Residue |
C | GLN89 |
C | SER134 |
site_id | AJ1 |
Number of Residues | 5 |
Details | binding site for residue EDO C 1124 |
Chain | Residue |
C | GLY675 |
C | THR676 |
C | ASP681 |
C | GLU826 |
C | LEU828 |
site_id | AJ2 |
Number of Residues | 2 |
Details | binding site for residue EDO C 1125 |
Chain | Residue |
C | LYS55 |
C | GLY691 |
site_id | AJ3 |
Number of Residues | 4 |
Details | binding site for residue EDO C 1126 |
Chain | Residue |
A | THR724 |
C | GLN218 |
C | ASN231 |
C | SER233 |
site_id | AJ4 |
Number of Residues | 2 |
Details | binding site for residue EDO C 1127 |
Chain | Residue |
B | LEU230 |
C | TYR811 |
site_id | AJ5 |
Number of Residues | 6 |
Details | binding site for residue EDO C 1128 |
Chain | Residue |
C | ASP83 |
C | THR85 |
C | THR87 |
C | PRO619 |
C | ARG620 |
C | HOH1450 |
site_id | AJ6 |
Number of Residues | 6 |
Details | binding site for residue PGE C 1129 |
Chain | Residue |
B | ARG168 |
C | MET69 |
C | LEU75 |
C | MET76 |
C | MET78 |
C | ASN820 |
site_id | AJ7 |
Number of Residues | 5 |
Details | binding site for residue EDO D 201 |
Chain | Residue |
B | GLU693 |
D | TYR56 |
D | TRP57 |
D | PHE90 |
D | HIS92 |
site_id | AJ8 |
Number of Residues | 3 |
Details | binding site for residue EDO D 202 |
Chain | Residue |
B | TYR811 |
D | ARG23 |
D | ASP44 |
site_id | AJ9 |
Number of Residues | 2 |
Details | binding site for residue EDO D 203 |
Chain | Residue |
D | ALA75 |
D | TYR76 |
site_id | AK1 |
Number of Residues | 3 |
Details | binding site for residue GOL E 201 |
Chain | Residue |
A | TYR811 |
E | ARG23 |
E | ASP44 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 462 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996 |
Chain | Residue | Details |
A | MET1-PRO9 | |
B | GLU414-ILE438 | |
B | ALA491-THR538 | |
B | ALA889-PRO898 | |
B | LEU944-LEU972 | |
B | ILE1019-HIS1049 | |
C | MET1-PRO9 | |
C | LEU357-THR365 | |
C | GLU414-ILE438 | |
C | ALA491-THR538 | |
C | ALA889-PRO898 | |
A | LEU357-THR365 | |
C | LEU944-LEU972 | |
C | ILE1019-HIS1049 | |
A | GLU414-ILE438 | |
A | ALA491-THR538 | |
A | ALA889-PRO898 | |
A | LEU944-LEU972 | |
A | ILE1019-HIS1049 | |
B | MET1-PRO9 | |
B | LEU357-THR365 |
site_id | SWS_FT_FI2 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=1 |
Chain | Residue | Details |
A | ILE10-LEU28 | |
B | ILE10-LEU28 | |
C | ILE10-LEU28 |
site_id | SWS_FT_FI3 |
Number of Residues | 1932 |
Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996 |
Chain | Residue | Details |
A | LYS29-SER336 | |
B | PHE556-ASN871 | |
B | ARG919-ASP924 | |
B | THR993-GLY998 | |
C | LYS29-SER336 | |
C | PHE386-ASN391 | |
C | PHE458-ALA465 | |
C | PHE556-ASN871 | |
C | ARG919-ASP924 | |
C | THR993-GLY998 | |
A | PHE386-ASN391 | |
A | PHE458-ALA465 | |
A | PHE556-ASN871 | |
A | ARG919-ASP924 | |
A | THR993-GLY998 | |
B | LYS29-SER336 | |
B | PHE386-ASN391 | |
B | PHE458-ALA465 |
site_id | SWS_FT_FI4 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=2 |
Chain | Residue | Details |
A | ILE337-TYR356 | |
B | ILE337-TYR356 | |
C | ILE337-TYR356 |
site_id | SWS_FT_FI5 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=3 |
Chain | Residue | Details |
A | LEU366-ALA385 | |
B | LEU366-ALA385 | |
C | LEU366-ALA385 |
site_id | SWS_FT_FI6 |
Number of Residues | 63 |
Details | TRANSMEM: Helical; Name=4 |
Chain | Residue | Details |
A | THR392-VAL413 | |
B | THR392-VAL413 | |
C | THR392-VAL413 |
site_id | SWS_FT_FI7 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=5 |
Chain | Residue | Details |
A | GLN439-ALA457 | |
B | GLN439-ALA457 | |
C | GLN439-ALA457 |
site_id | SWS_FT_FI8 |
Number of Residues | 72 |
Details | TRANSMEM: Helical; Name=6 |
Chain | Residue | Details |
A | ILE466-PRO490 | |
B | ILE466-PRO490 | |
C | ILE466-PRO490 |
site_id | SWS_FT_FI9 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=7 |
Chain | Residue | Details |
A | GLY539-LEU555 | |
B | GLY539-LEU555 | |
C | GLY539-LEU555 |
site_id | SWS_FT_FI10 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=8 |
Chain | Residue | Details |
A | GLN872-LEU888 | |
B | GLN872-LEU888 | |
C | GLN872-LEU888 |
site_id | SWS_FT_FI11 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=9 |
Chain | Residue | Details |
A | PHE899-PHE918 | |
B | PHE899-PHE918 | |
C | PHE899-PHE918 |
site_id | SWS_FT_FI12 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=10 |
Chain | Residue | Details |
A | VAL925-ILE943 | |
B | VAL925-ILE943 | |
C | VAL925-ILE943 |
site_id | SWS_FT_FI13 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=11 |
Chain | Residue | Details |
A | ARG973-SER992 | |
B | ARG973-SER992 | |
C | ARG973-SER992 |
site_id | SWS_FT_FI14 |
Number of Residues | 57 |
Details | TRANSMEM: Helical; Name=12 |
Chain | Residue | Details |
A | ALA999-ALA1018 | |
B | ALA999-ALA1018 | |
C | ALA999-ALA1018 |