6ZO6
Minocycline binding to the deep binding pocket of AcrB-G619P
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1101 |
| Chain | Residue |
| A | LEU28 |
| A | VAL32 |
| A | VAL341 |
| A | ILE348 |
| A | PHE380 |
| A | HOH1202 |
| B | 8K61131 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue LMT A 1102 |
| Chain | Residue |
| A | CYS887 |
| A | LEU891 |
| C | ARG8 |
| A | GLY440 |
| A | GLY444 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue LMT A 1103 |
| Chain | Residue |
| A | SER530 |
| A | GLY533 |
| A | ARG536 |
| A | ARG540 |
| A | TYR541 |
| A | HOH1341 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue DDQ A 1105 |
| Chain | Residue |
| A | PHE386 |
| A | ARG468 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 1106 |
| Chain | Residue |
| A | GLY51 |
| A | GLY755 |
| A | MET774 |
| A | GOL1107 |
| A | HOH1204 |
| A | HOH1307 |
| A | HOH1382 |
| C | GLY221 |
| C | THR222 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 1107 |
| Chain | Residue |
| A | PRO50 |
| A | ARG185 |
| A | GLU273 |
| A | GLY755 |
| A | TYR772 |
| A | MET774 |
| A | GOL1106 |
| A | HOH1203 |
| A | HOH1307 |
| A | HOH1347 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1108 |
| Chain | Residue |
| A | ALA47 |
| A | SER48 |
| A | GLY126 |
| A | SER128 |
| A | EDO1115 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1109 |
| Chain | Residue |
| A | ASP566 |
| A | GLU567 |
| A | ASP568 |
| A | LYS643 |
| A | GLY998 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1110 |
| Chain | Residue |
| A | GLU593 |
| A | HIS596 |
| A | TYR597 |
| A | LYS601 |
| A | HOH1424 |
| B | GLY227 |
| B | GLN229 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1111 |
| Chain | Residue |
| A | SER742 |
| A | ILE743 |
| A | ASN744 |
| A | HOH1333 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue D12 A 1112 |
| Chain | Residue |
| A | TRP895 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue HEX A 1113 |
| Chain | Residue |
| A | PHE885 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1114 |
| Chain | Residue |
| A | PRO36 |
| A | THR37 |
| A | SER389 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1115 |
| Chain | Residue |
| A | SER128 |
| A | GLU130 |
| A | GLN176 |
| A | GOL1108 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1116 |
| Chain | Residue |
| A | THR243 |
| A | ARG263 |
| A | HOH1464 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue PGE A 1117 |
| Chain | Residue |
| A | ASN144 |
| A | THR148 |
| A | MET149 |
| A | ASP153 |
| A | ASP156 |
| A | SER319 |
| A | ARG765 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue MIY B 1101 |
| Chain | Residue |
| B | PHE178 |
| B | GLY179 |
| B | SER180 |
| B | ASN274 |
| B | ASP276 |
| B | ILE277 |
| B | ALA279 |
| B | PHE615 |
| B | HOH1272 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue LMT B 1102 |
| Chain | Residue |
| B | SER530 |
| B | GLY533 |
| B | ILE534 |
| B | ARG536 |
| B | SER537 |
| B | TYR541 |
| B | PHE1020 |
| B | D101107 |
| B | HOH1278 |
| D | ASP72 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue LMT B 1103 |
| Chain | Residue |
| B | LYS509 |
| B | LYS510 |
| B | PHE512 |
| B | TRP515 |
| B | ARG518 |
| B | GLY508 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue DDR B 1104 |
| Chain | Residue |
| B | VAL452 |
| B | PHE459 |
| B | TYR467 |
| B | MET552 |
| B | TYR877 |
| B | SER880 |
| B | LEU881 |
| B | VAL905 |
| B | GLN928 |
| B | LEU931 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue DDQ B 1106 |
| Chain | Residue |
| A | TRP13 |
| B | TRP895 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue D10 B 1107 |
| Chain | Residue |
| B | LMT1102 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue D10 B 1108 |
| Chain | Residue |
| B | ASN298 |
| B | ASP301 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue D10 B 1109 |
| Chain | Residue |
| B | PHE11 |
| C | MET447 |
| C | CYS887 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 1110 |
| Chain | Residue |
| A | ARG168 |
| A | GLU309 |
| A | HOH1286 |
| B | LEU75 |
| B | MET76 |
| B | TYR77 |
| B | MET78 |
| B | ASN820 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1111 |
| Chain | Residue |
| B | PHE358 |
| B | LEU359 |
| B | GLN360 |
| B | ILE500 |
| B | ASP504 |
| B | GLY506 |
| B | LYS509 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 1112 |
| Chain | Residue |
| B | GLU593 |
| B | TYR597 |
| B | ALA654 |
| B | ILE658 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 1113 |
| Chain | Residue |
| B | THR238 |
| C | LYS728 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 1114 |
| Chain | Residue |
| B | HIS692 |
| B | HOH1290 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue HEX B 1115 |
| Chain | Residue |
| B | ALA384 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue MYS B 1119 |
| Chain | Residue |
| B | PHE885 |
| B | PHE899 |
| site_id | AF5 |
| Number of Residues | 12 |
| Details | binding site for residue PG4 B 1120 |
| Chain | Residue |
| A | ASN109 |
| B | GLN108 |
| B | GLN112 |
| B | MET115 |
| B | GLY126 |
| B | VAL127 |
| B | HOH1378 |
| C | GLN108 |
| C | GLN112 |
| C | MET115 |
| C | VAL127 |
| C | VAL129 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1121 |
| Chain | Residue |
| B | GLU810 |
| B | TYR811 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1122 |
| Chain | Residue |
| B | ASN700 |
| D | ARG23 |
| D | TRP57 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1123 |
| Chain | Residue |
| B | GLY856 |
| B | TYR857 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1124 |
| Chain | Residue |
| A | HOH1236 |
| B | ARG185 |
| B | GLU273 |
| B | ASN274 |
| B | MET774 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1125 |
| Chain | Residue |
| B | ASN189 |
| B | ARG263 |
| B | ASP264 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1126 |
| Chain | Residue |
| B | SER46 |
| B | SER48 |
| B | GLN125 |
| B | GLY126 |
| B | SER128 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1127 |
| Chain | Residue |
| B | HIS505 |
| B | ARG973 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1128 |
| Chain | Residue |
| A | ALA209 |
| B | ILE743 |
| B | ASN744 |
| B | ASN747 |
| site_id | AG5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1129 |
| Chain | Residue |
| B | ASN760 |
| B | ASP761 |
| C | GLN120 |
| C | GLU121 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1130 |
| Chain | Residue |
| B | PHE727 |
| B | PRO783 |
| B | ILE786 |
| B | SER802 |
| B | SER805 |
| B | SER807 |
| B | HOH1368 |
| site_id | AG7 |
| Number of Residues | 1 |
| Details | binding site for residue 8K6 B 1131 |
| Chain | Residue |
| A | LMT1101 |
| site_id | AG8 |
| Number of Residues | 3 |
| Details | binding site for residue R16 B 1132 |
| Chain | Residue |
| B | LYS29 |
| C | VAL454 |
| C | SER875 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1133 |
| Chain | Residue |
| B | ASN361 |
| B | PHE362 |
| B | ARG363 |
| B | LYS498 |
| site_id | AH1 |
| Number of Residues | 1 |
| Details | binding site for residue C14 C 1101 |
| Chain | Residue |
| C | TYR892 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue LMT C 1102 |
| Chain | Residue |
| C | SER530 |
| C | GLY533 |
| C | ARG536 |
| C | SER537 |
| C | TYR541 |
| C | DDQ1106 |
| site_id | AH3 |
| Number of Residues | 7 |
| Details | binding site for residue PTY C 1103 |
| Chain | Residue |
| B | TRP13 |
| C | GLU893 |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | PHE1033 |
| C | SER1034 |
| site_id | AH4 |
| Number of Residues | 1 |
| Details | binding site for residue OCT C 1104 |
| Chain | Residue |
| C | PHE380 |
| site_id | AH5 |
| Number of Residues | 3 |
| Details | binding site for residue OCT C 1105 |
| Chain | Residue |
| C | PHE458 |
| C | ARG468 |
| C | LPX1119 |
| site_id | AH6 |
| Number of Residues | 2 |
| Details | binding site for residue DDQ C 1106 |
| Chain | Residue |
| C | SER530 |
| C | LMT1102 |
| site_id | AH7 |
| Number of Residues | 2 |
| Details | binding site for residue D10 C 1108 |
| Chain | Residue |
| C | PHE556 |
| C | VAL557 |
| site_id | AH8 |
| Number of Residues | 1 |
| Details | binding site for residue D10 C 1109 |
| Chain | Residue |
| C | ALA384 |
| site_id | AH9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 1110 |
| Chain | Residue |
| B | HOH1354 |
| C | ARG185 |
| C | GLU273 |
| C | GLY755 |
| C | GLY756 |
| C | TYR772 |
| C | HOH1401 |
| site_id | AI1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 1111 |
| Chain | Residue |
| A | VAL64 |
| C | TYR758 |
| C | ASP761 |
| C | LYS770 |
| C | HOH1244 |
| site_id | AI2 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 1113 |
| Chain | Residue |
| C | LYS950 |
| C | ARG1030 |
| site_id | AI3 |
| Number of Residues | 1 |
| Details | binding site for residue D12 C 1115 |
| Chain | Residue |
| C | PHE4 |
| site_id | AI4 |
| Number of Residues | 2 |
| Details | binding site for residue HEX C 1117 |
| Chain | Residue |
| C | ALA385 |
| C | LPX1119 |
| site_id | AI5 |
| Number of Residues | 10 |
| Details | binding site for residue LPX C 1119 |
| Chain | Residue |
| C | PHE388 |
| C | ALA457 |
| C | ARG468 |
| C | GLN469 |
| C | SER471 |
| C | SER476 |
| C | LEU480 |
| C | OCT1105 |
| C | HEX1117 |
| C | HOH1286 |
| site_id | AI6 |
| Number of Residues | 12 |
| Details | binding site for residue 1PE C 1120 |
| Chain | Residue |
| C | GLU339 |
| C | ASP566 |
| C | GLU567 |
| C | ASP568 |
| C | TRP634 |
| C | LYS643 |
| C | THR993 |
| C | GLY994 |
| C | ALA995 |
| C | SER997 |
| C | HOH1292 |
| C | HOH1299 |
| site_id | AI7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1121 |
| Chain | Residue |
| C | GLY283 |
| C | GLN284 |
| site_id | AI8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 1122 |
| Chain | Residue |
| C | GLU607 |
| C | SER630 |
| C | LEU631 |
| C | ASP633 |
| site_id | AI9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1123 |
| Chain | Residue |
| C | GLN89 |
| C | SER134 |
| site_id | AJ1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 1124 |
| Chain | Residue |
| C | GLY675 |
| C | THR676 |
| C | ASP681 |
| C | GLU826 |
| C | LEU828 |
| site_id | AJ2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1125 |
| Chain | Residue |
| C | LYS55 |
| C | GLY691 |
| site_id | AJ3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 1126 |
| Chain | Residue |
| A | THR724 |
| C | GLN218 |
| C | ASN231 |
| C | SER233 |
| site_id | AJ4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 1127 |
| Chain | Residue |
| B | LEU230 |
| C | TYR811 |
| site_id | AJ5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 1128 |
| Chain | Residue |
| C | ASP83 |
| C | THR85 |
| C | THR87 |
| C | PRO619 |
| C | ARG620 |
| C | HOH1450 |
| site_id | AJ6 |
| Number of Residues | 6 |
| Details | binding site for residue PGE C 1129 |
| Chain | Residue |
| B | ARG168 |
| C | MET69 |
| C | LEU75 |
| C | MET76 |
| C | MET78 |
| C | ASN820 |
| site_id | AJ7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 201 |
| Chain | Residue |
| B | GLU693 |
| D | TYR56 |
| D | TRP57 |
| D | PHE90 |
| D | HIS92 |
| site_id | AJ8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 202 |
| Chain | Residue |
| B | TYR811 |
| D | ARG23 |
| D | ASP44 |
| site_id | AJ9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 203 |
| Chain | Residue |
| D | ALA75 |
| D | TYR76 |
| site_id | AK1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 201 |
| Chain | Residue |
| A | TYR811 |
| E | ARG23 |
| E | ASP44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
