6ZOD

Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8 groove, and TM1/TM2 groove of the fully induced AcrB T protomer

Summary for 6ZOD

• Entry DOI: 10.2210/pdb6zod/pdb
• Descriptor: Multidrug efflux pump subunit AcrB, SULFATE ION, PHOSPHATIDYLETHANOLAMINE, ... (14 entities in total)
• Functional Keywords: multidrug efflux pump, membrane protein, transport protein
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 5
• Total formula weight: 390494.48

Authors

Oswald, C.,Tam, H.K.,Pos, K.M. (deposition date: 2020-07-07, release date: 2021-05-19, Last modification date: 2024-01-31)

• Primary citation: Tam, H.K.,Foong, W.E.,Oswald, C.,Herrmann, A.,Zeng, H.,Pos, K.M.; Allosteric drug transport mechanism of multidrug transporter AcrB.; Nat Commun, 12:3889-3889, 2021; PubMed: 34188038; DOI: 10.1038/s41467-021-24151-3

Experimental method

X-RAY DIFFRACTION (2.85 Å)