6ZOD
Fusidic acid binding to the allosteric deep transmembrane domain binding pocket, TM7/TM8 groove, and TM1/TM2 groove of the fully induced AcrB T protomer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Multidrug efflux pump subunit AcrB | polymer | 1057 | 114736.3 | 3 | UniProt (P31224) Pfam (PF00873) | Escherichia coli (strain K12) | AcrAB-TolC multidrug efflux pump subunit AcrB,Acridine resistance protein B |
| 2 | D, E (D, E) | DARPIN | polymer | 169 | 18317.6 | 2 | synthetic construct | ||
| 3 | F, H, JA, MA, NA... (A, C) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 7 | Chemie (LMT) | |||
| 4 | G, HA, I, IA, K... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 5 | J, T (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | L, Y (A, B) | DECANE | non-polymer | 142.3 | 2 | Chemie (D10) | |||
| 7 | EA, FA, GA, R (B, A) | FUSIDIC ACID | non-polymer | 516.7 | 4 | Chemie (FUA) | |||
| 8 | V (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 9 | Z (B) | Octadecane | non-polymer | 254.5 | 1 | Chemie (8K6) | |||
| 10 | AA, BA, CA, DA, RA (B, C) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 11 | KA, OA (C) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 2 | Chemie (PTY) | |||
| 12 | PA (C) | DODECANE | non-polymer | 170.3 | 1 | Chemie (D12) | |||
| 13 | QA (C) | HEXANE | non-polymer | 86.2 | 1 | Chemie (HEX) | |||
| 14 | UA, VA, WA, XA, YA (A, B, C, D, E) | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 1049 (UniProt: P31224)
| PDB | External Database | Details |
|---|---|---|
| Leu 1050 | - | expression tag |
| Glu 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
| His 1057 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 380844.0 | |
| Non-Polymers* | Number of molecules | 41 |
| Total formula weight | 9650.5 | |
| All* | Total formula weight | 390494.5 |
