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7U9Q
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Structure of PKA phosphorylated human RyR2 in the closed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7UA3
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Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7U9Z
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Structure of PKA phosphorylated human RyR2-R2474S in the open state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7U9X
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Structure of PKA phosphorylated human RyR2-R2474S in the closed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (2.58 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7UA1
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Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of ARM210
分子名称: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7UA4
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Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7U9R
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Structure of PKA phosphorylated human RyR2 in the open state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7U0U
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Crystal Structure of a Aspergillus fumigatus Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, PHOSPHATE ION, ...
著者Fox III, D, Abendroth, J, DeBouver, N.D, Hoy, M.J, Heitman, J, Lorimer, D.D, Horanyi, P.S, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-02-18
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
Mbio, 13, 2022
7UA5
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Structure of dephosphorylated human RyR2 in the closed state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ...
著者Miotto, M.C, Marks, A.R.
登録日2022-03-11
公開日2022-08-03
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
7U0T
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Crystal Structure of a human Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-520
分子名称: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,22R,26aS)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 1,2-ETHANEDIOL, CALCIUM ION, ...
著者Fox III, D, Mayclin, S.J, DeBouver, N.D, Hoy, M.J, Heitman, J, Lorimer, D.D, Horanyi, P.S, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-02-18
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
Mbio, 13, 2022
7U0S
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Crystal Structure of FK506-binding protein 1A from Aspergillus fumigatus Bound to Ascomycin
分子名称: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,22R,26aS)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone, ACETATE ION, FK506-binding protein 1A, ...
著者DeBouver, N.D, Fox III, D, Hoy, M.J, Heitman, J, Lorimer, D.D, Horanyi, P.S, Edwards, T.E, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-02-18
公開日2022-07-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
Mbio, 13, 2022
7T64
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Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6 embedded in lipidic nanodisc in the closed state
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION
著者Iyer, K.A, Hu, Y, Murayama, T, Samso, M.
登録日2021-12-13
公開日2022-07-20
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
7T65
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Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6 embedded in lipidic nanodisc in the open state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
著者Iyer, K.A, Hu, Y, Murayama, T, Samso, M.
登録日2021-12-13
公開日2022-07-20
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (4.05 Å)
主引用文献Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
7TZC
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A drug and ATP binding site in type 1 ryanodine receptor
分子名称: (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Melville, Z, Dridi, H, Yuan, Q, Reiken, S, Anetta, W, Liu, Y, Clarke, O.B, Marks, A.R.
登録日2022-02-15
公開日2022-05-18
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.45 Å)
主引用文献A drug and ATP binding site in type 1 ryanodine receptor.
Structure, 30, 2022
7OXG
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ttSlyD FKBP domain with M8A pseudo-wild-type S2 peptide
分子名称: 30S ribosomal protein S2, CHLORIDE ION, IMIDAZOLE, ...
著者Pazicky, S, Lei, J, Loew, C.
登録日2021-06-22
公開日2022-03-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7OXJ
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ttSlyD with M8A pseudo-wild-type S2 peptide
分子名称: 30S ribosomal protein S2, CHLORIDE ION, Fragment of 30S ribosomal protein S2 peptide, ...
著者Pazicky, S, Lei, J, Loew, C.
登録日2021-06-22
公開日2022-03-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7OXH
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ttSlyD with pseudo-wild-type S2 peptide
分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 30S ribosomal protein S2, CHLORIDE ION, ...
著者Pazicky, S, Lei, J, Loew, C.
登録日2021-06-22
公開日2022-03-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7OXI
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ttSlyD with W4A pseudo-wild-type S2 peptide
分子名称: 30S ribosomal protein S2, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase
著者Pazicky, S, Lei, J, Loew, C.
登録日2021-06-22
公開日2022-03-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7OXK
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ttSlyD with W4K pseudo-wild-type S2 peptide
分子名称: 30S ribosomal protein S2, Peptidyl-prolyl cis-trans isomerase
著者Pazicky, S, Lei, J, Loew, C.
登録日2021-06-22
公開日2022-03-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7WFF
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Subcomplexes B,M and L in the Cylic electron transfer supercomplex NDH-PSI from Arabidopsis
分子名称: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, FE2/S2 (INORGANIC) CLUSTER, ...
著者Pan, X.W, Li, M.
登録日2021-12-26
公開日2022-03-16
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana.
Mol Plant, 15, 2022
7WG5
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Cyclic electron transport supercomplex NDH-PSI from Arabidopsis
分子名称: (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ...
著者Pan, X.W, Li, M.
登録日2021-12-28
公開日2022-03-16
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana.
Mol Plant, 15, 2022
7F2J
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Crystal structure of AtFKBP53 FKBD in complex with rapamycin
分子名称: DI(HYDROXYETHYL)ETHER, Peptidyl-prolyl cis-trans isomerase FKBP53, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ...
著者Singh, A.K, Saharan, K, Vasudevan, D.
登録日2021-06-11
公開日2022-03-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain.
Int.J.Biol.Macromol., 206, 2022
7DKI
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Silk worm FKBP, isoform-1
分子名称: GLYCEROL, Peptidylprolyl isomerase
著者Yuchi, Z, Nayak, B.C.
登録日2020-11-24
公開日2022-02-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Silk worm FKBP, isoform-1
To Be Published
7ETT
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BU of 7ett by Molmil
The FK1 domain of FKBP51 in complex with peptide-inhibitor hit QFPFV
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, peptide-inhibitor hit
著者Han, J.T, Zhu, Y.C, Pan, D.B, Xue, H.X, Wang, S, Liu, H.X, He, Y.X, Yao, X.J.
登録日2021-05-14
公開日2022-02-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery of pentapeptide-inhibitor hits targeting FKBP51 by combining computational modeling and X-ray crystallography.
Comput Struct Biotechnol J, 19, 2021
7ETU
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The FK1 domain of FKBP51 in complex with peptide-inhibitor hit SFPFT
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, peptide-inhibitor hit
著者Han, J.T, Zhu, Y.C, Pan, D.B, Xue, H.X, Wang, S, Liu, H.X, He, Y.X, Yao, X.J.
登録日2021-05-14
公開日2022-02-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Discovery of pentapeptide-inhibitor hits targeting FKBP51 by combining computational modeling and X-ray crystallography.
Comput Struct Biotechnol J, 19, 2021

221051

件を2024-06-12に公開中

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