7U0T

Crystal Structure of a human Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-520

Summary for 7U0T

• Entry DOI: 10.2210/pdb7u0t/pdb
• Descriptor: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform,Calcineurin subunit B type 1 fusion, Peptidylprolyl isomerase, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: ssgcid, cna, cnb, fkbp12, peptidyl prolyl cis-trans isomerase, phosphatase, fk-520, structural genomics, seattle structural genomics center for infectious disease, hydrolase-isomerase complex, anti-fungal, hydrolase/isomerase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 44762.35

Authors

Fox III, D.,Mayclin, S.J.,DeBouver, N.D.,Hoy, M.J.,Heitman, J.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-02-18, release date: 2022-08-03, Last modification date: 2023-10-18)

• Primary citation: Hoy, M.J.,Park, E.,Lee, H.,Lim, W.Y.,Cole, D.C.,DeBouver, N.D.,Bobay, B.G.,Pierce, P.G.,Fox 3rd, D.,Ciofani, M.,Juvvadi, P.R.,Steinbach, W.,Hong, J.,Heitman, J.; Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.; Mbio, 13:e0104922-e0104922, 2022; PubMed: 35604094; DOI: 10.1128/mbio.01049-22

Experimental method

X-RAY DIFFRACTION (2.45 Å)