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7U0T

Crystal Structure of a human Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-520

Functional Information from GO Data
ChainGOidnamespacecontents
A0001569biological_processbranching involved in blood vessel morphogenesis
A0001837biological_processepithelial to mesenchymal transition
A0004721molecular_functionphosphoprotein phosphatase activity
A0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005955cellular_componentcalcineurin complex
A0006606biological_processprotein import into nucleus
A0007507biological_processheart development
A0008287cellular_componentprotein serine/threonine phosphatase complex
A0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
A0014044biological_processSchwann cell development
A0016018molecular_functioncyclosporin A binding
A0019902molecular_functionphosphatase binding
A0019904molecular_functionprotein domain specific binding
A0022011biological_processmyelination in peripheral nervous system
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034504biological_processprotein localization to nucleus
A0042383cellular_componentsarcolemma
A0045202cellular_componentsynapse
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0060487biological_processlung epithelial cell differentiation
A0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
A0097720biological_processcalcineurin-mediated signaling
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098693biological_processregulation of synaptic vesicle cycle
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A1905665biological_processpositive regulation of calcium ion import across plasma membrane
A1905949biological_processnegative regulation of calcium ion import across plasma membrane
B0000413biological_processprotein peptidyl-prolyl isomerization
B0003007biological_processheart morphogenesis
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005527molecular_functionmacrolide binding
B0005528molecular_functionFK506 binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006457biological_processprotein folding
B0006458biological_process'de novo' protein folding
B0014802cellular_componentterminal cisterna
B0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016247molecular_functionchannel regulator activity
B0016529cellular_componentsarcoplasmic reticulum
B0022417biological_processprotein maturation by protein folding
B0030018cellular_componentZ disc
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0030547molecular_functionsignaling receptor inhibitor activity
B0032092biological_processpositive regulation of protein binding
B0032880biological_processregulation of protein localization
B0032926biological_processnegative regulation of activin receptor signaling pathway
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034713molecular_functiontype I transforming growth factor beta receptor binding
B0042026biological_processprotein refolding
B0042110biological_processT cell activation
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044325molecular_functiontransmembrane transporter binding
B0050776biological_processregulation of immune response
B0055010biological_processventricular cardiac muscle tissue morphogenesis
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060347biological_processheart trabecula formation
B0070411molecular_functionI-SMAD binding
B0070588biological_processcalcium ion transmembrane transport
B0070697molecular_functionactivin receptor binding
B0097435biological_processsupramolecular fiber organization
B0098562cellular_componentcytoplasmic side of membrane
B1902991biological_processregulation of amyloid precursor protein catabolic process
B1990000biological_processamyloid fibril formation
B1990425cellular_componentryanodine receptor complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
ChainResidueDetails
AASP30-PHE42
AASP62-PHE74
AASP99-LEU111
AASP140-PHE152

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
ChainResidueDetails
BLYS52
AGLU73
AASP140
AASP142
AASP144
AARG146
AGLU151
AASP32
ASER34
ASER36
AGLU41
AASP62
AASP64
AASN66
AGLU68

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
ChainResidueDetails
AASP99
AASP101
AASP103
ATYR105
AGLU110

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Interaction with PxVP motif in substrates of the catalytic subunit => ECO:0000269|PubMed:23468591
ChainResidueDetails
AMET117
AASN121

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q63810
ChainResidueDetails
ATYR105

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
BTYR26electrostatic destabiliser, steric role
BPHE36electrostatic destabiliser, polar/non-polar interaction, steric role
BASP37electrostatic stabiliser, steric role
BILE56electrostatic stabiliser, steric role
BTYR82electrostatic stabiliser, steric role
BPHE99electrostatic destabiliser, polar/non-polar interaction, steric role

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PDB entries from 2024-07-24

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