7U0T
Crystal Structure of a human Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-520
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform,Calcineurin subunit B type 1 fusion | polymer | 244 | 27115.4 | 1 | UniProt (P48454) UniProt (P63098) Pfam (PF13499) In PDB | Homo sapiens (human) | CAM-PRP catalytic subunit,Calcineurin,testis-specific catalytic subunit,Calmodulin-dependent calcineurin A subunit gamma isoform,Protein phosphatase 2B regulatory subunit 1,Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
2 | B | Peptidylprolyl isomerase | polymer | 150 | 16632.6 | 1 | UniProt (Q0VDC6) Pfam (PF00254) UniProt (by SIFTS) (P62942) In PDB | Homo sapiens (human) | |
3 | A | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
5 | B | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,22R,26aS)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone | non-polymer | 792.0 | 1 | Chemie (KXX) | |||
6 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: -52 - -17 (UniProt: P48454)
A: 2 - 169 (UniProt: P63098)
B: 1 - 107 (UniProt: Q0VDC6)
PDB | External Database | Details |
---|---|---|
Met -74 | - | initiating methionine |
Ser -73 | - | expression tag |
Gly -72 | - | expression tag |
Ser -71 | - | expression tag |
His -70 | - | expression tag |
His -69 | - | expression tag |
His -68 | - | expression tag |
His -67 | - | expression tag |
His -66 | - | expression tag |
His -65 | - | expression tag |
His -64 | - | expression tag |
His -63 | - | expression tag |
Gly -62 | - | expression tag |
Gly -61 | - | expression tag |
Glu -60 | - | expression tag |
Asn -59 | - | expression tag |
Leu -58 | - | expression tag |
Tyr -57 | - | expression tag |
Phe -56 | - | expression tag |
Gln -55 | - | expression tag |
Gly -54 | - | expression tag |
Ser -53 | - | expression tag |
Gly -16 | - | linker |
Gly -15 | - | linker |
Gly -14 | - | linker |
Ser -13 | - | linker |
Ser -12 | - | linker |
Gly -11 | - | linker |
Gly -10 | - | linker |
Ser -9 | - | linker |
Thr -8 | - | linker |
Ser -7 | - | linker |
Gly -6 | - | linker |
Gly -5 | - | linker |
Ser -4 | - | linker |
Ser -3 | - | linker |
Gly -2 | - | linker |
Gly -1 | - | linker |
Gly 0 | - | linker |
Gly 1 | - | linker |
B: 1 - 107 (UniProt: Q0VDC6)
PDB | External Database | Details |
---|---|---|
Met -42 | - | initiating methionine |
Ser -41 | - | expression tag |
Gly -40 | - | expression tag |
Ser -39 | - | expression tag |
His -38 | - | expression tag |
His -37 | - | expression tag |
His -36 | - | expression tag |
His -35 | - | expression tag |
His -34 | - | expression tag |
His -33 | - | expression tag |
His -32 | - | expression tag |
His -31 | - | expression tag |
Gly -30 | - | expression tag |
Gly -29 | - | expression tag |
Glu -28 | - | expression tag |
Asn -27 | - | expression tag |
Leu -26 | - | expression tag |
Tyr -25 | - | expression tag |
Phe -24 | - | expression tag |
Gln -23 | - | expression tag |
Gly -22 | - | expression tag |
Ser -21 | - | expression tag |
Gly -20 | - | expression tag |
Leu -19 | - | expression tag |
Asn -18 | - | expression tag |
Asp -17 | - | expression tag |
Ile -16 | - | expression tag |
Phe -15 | - | expression tag |
Glu -14 | - | expression tag |
Ala -13 | - | expression tag |
Gln -12 | - | expression tag |
Lys -11 | - | expression tag |
Ile -10 | - | expression tag |
Glu -9 | - | expression tag |
Trp -8 | - | expression tag |
His -7 | - | expression tag |
Glu -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
Ser -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43748.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1014.4 | |
All* | Total formula weight | 44762.3 |