PDB: 82203 件ウェブページステータス検索Chemie searchBIRD

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2FO8	Solution structure of the Trypanosoma cruzi cysteine protease inhibitor chagasin 分子名称: Chagasin 著者 Salmon, D, do Aido-Machado, R, de Lima, A.A.P, Scharfstein, J, Oschkinat, H, Pires, J.R. 登録日 2006-01-13 公開日 2006-04-04 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 Solution Structure and Backbone Dynamics of the Trypanosoma cruzi Cysteine Protease Inhibitor Chagasin J.Mol.Biol., 357, 2006
5VTL	Structure of metacyclic invariant surface protein , Tb427.07.360, from Trypanosoma brucei. 分子名称: Tb427.07.360- putative uncharacterized metacyclic invariant surface protein from Trypanosoma brucei 著者 Ramswamy, R, Workman, S.D, Boulanger, M.J. 登録日 2017-05-17 公開日 2018-08-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8231 Å) 主引用文献 Structure of Tb427.07.360, an insect stage antigen from Trypanosoma brucei. to be published
6RSU	TBK1 in complex with Inhibitor compound 35 分子名称: 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one, Serine/threonine-protein kinase TBK1 著者 Panne, D, Hillig, R.C, Rengachari, S. 登録日 2019-05-22 公開日 2020-04-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
8A0K	crystal structure of the kinetoplastid kinetochore protein Trypanosoma brucei KKT3 Divergent Polo-Box domain 分子名称: DI(HYDROXYETHYL)ETHER, Protein kinase, putative 著者 Ishii, M, Ludzia, P, Marciano, G, Allen, W, Nerusheva, O.O, Akiyoshi, B. 登録日 2022-05-27 公開日 2022-06-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei. Mol.Biol.Cell, 33, 2022
2E6F	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate 分子名称: COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-12-26 公開日 2008-01-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate To be Published
2B4G	dihydroorotate dehydrogenase 分子名称: BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2005-09-23 公開日 2005-10-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies Mol.Microbiol., 68, 2008
2DJL	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate 分子名称: COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-04-04 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate To be Published
7A1I	Crystal structure of the BILBO2/FPC4 complex 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BILBO1_N domain-containing protein, ... 著者 Dong, G. 登録日 2020-08-13 公開日 2021-07-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar. Plos Pathog., 17, 2021
8D1R	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT520 分子名称: 1-{3-[(4-chlorophenyl)methoxy]phenyl}methanamine, GLYCEROL, N-acetyltransferase Eis 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-05-27 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242, 2022
8D25	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT530 分子名称: 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-4-yl)methyl]methanamine, GLYCEROL, N-acetyltransferase Eis 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-05-27 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242, 2022
8A0J	Crystal structure of the kinetoplastid kinetochore protein Trypanosoma congolense KKT2 divergent polo-box domain 分子名称: Uncharacterized protein TCIL3000_11_11110 著者 Ishii, M, Ludzia, P, Marciano, G, Allen, W, Nerusheva, O, Akiyoshi, B. 登録日 2022-05-27 公開日 2022-06-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei. Mol.Biol.Cell, 33, 2022
8F4A	Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chlorhexidine 分子名称: 1-[6-[azanylidene-[[azanylidene-[[(4-chlorophenyl)amino]methyl]-$l^{4}-azanyl]methyl]-$l^{4}-azanyl]hexyl]-3-[~{N}-(4-chlorophenyl)carbamimidoyl]guanidine, GLYCEROL, N-acetyltransferase Eis 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-10 公開日 2023-02-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8F55	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis H37Rv in complex with inhibitor SGT1614 分子名称: (2E)-2-[(4-chlorophenyl)methylidene]hydrazine-1-carboximidamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-11 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8F57	Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with inhibitor SGT1615 分子名称: (1E)-1-[(4-chlorophenyl)methylidene]-2-(3-fluorophenyl)hydrazine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-12 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8F4W	Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with venlafaxine 分子名称: 1-[(1R)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-11 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8F4Z	Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chloroquine 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-acetyltransferase Eis, ... 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-11 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8F58	Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with inhibitor SGT1616 分子名称: (1E)-1-[(4-chlorophenyl)methylidene]-2-(4-fluorophenyl)hydrazine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-12 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8F51	Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with mefloquine 分子名称: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-11-11 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62, 2023
8D23	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT529 分子名称: 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-3-yl)methyl]methanamine, GLYCEROL, N-acetyltransferase Eis 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-05-27 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242, 2022
2E68	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-12-26 公開日 2008-01-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate To be Published
2E6A	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate 分子名称: COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-12-26 公開日 2008-01-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with orotate To be Published
4UTX	Crystal structure of zebrafish Sirtuin 5 in complex with 3-nitro- propionylated CPS1-peptide 分子名称: 1,2-ETHANEDIOL, 3-NITROPROPANOIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Pannek, M, Gertz, M, Steegborn, C. 登録日 2014-07-23 公開日 2014-08-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53, 2014
420D	CRYSTAL STRUCTURE OF A 16-MER RNA DUPLEX WITH NON-ADJACENT A(ANTI).G(SYN) MISMATCHES 分子名称: RNA (5'-R(*GP*CP*AP*GP*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3'), SODIUM ION 著者 Pan, B, Mitra, S.N, Sundaralingam, M. 登録日 1998-08-13 公開日 1999-01-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of an RNA 16-mer duplex R(GCAGAGUUAAAUCUGC)2 with nonadjacent G(syn).A+(anti) mispairs. Biochemistry, 38, 1999
6AJA	Crystal structure of Trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADPH, alpha-ketoglutarate and ca2+ 分子名称: 2-OXOGLUTARIC ACID, CALCIUM ION, GLYCEROL, ... 著者 Wang, X, Inaoka, D.K, Shiba, T, Balogun, E.O, Ziebart, N, Allman, S, Watanabe, Y, Nozaki, T, Boshart, M, Bringaud, F, Harada, S, Kita, K. 登録日 2018-08-27 公開日 2019-08-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Biochemical characterization of a novel Trypanosoma brucei glycosomal isocitrate dehydrogenase with dual coenzyme specificity (NADP+/NAD+) To Be Published
3MCV	Structure of PTR1 from Trypanosoma brucei in ternary complex with 2,4-diamino-5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]-pyrimidine and NADP+ 分子名称: 5-[2-(2,5-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Tulloch, L.B, Hunter, W.N. 登録日 2010-03-29 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target. Acta Crystallogr.,Sect.D, 66, 2010

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